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  • 苦莓苷F1

    Niga-ichigoside F1

    苦莓苷F1
    产品编号 CFN91060
    CAS编号 95262-48-9
    分子式 = 分子量 C36H58O11 = 666.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The tuberous roots of Potentilla anserina
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苦莓苷F1 CFN91060 95262-48-9 10mg QQ客服:215959384
    苦莓苷F1 CFN91060 95262-48-9 20mg QQ客服:215959384
    苦莓苷F1 CFN91060 95262-48-9 50mg QQ客服:215959384
    苦莓苷F1 CFN91060 95262-48-9 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • University of Madras (India)
  • Kyung Hee University (Korea)
  • University of Minnesota (USA)
  • Shanghai University of TCM (China)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Mahidol University (Thailand)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Hertfordshire (United Kingdom)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Mahatma Gandhi University (India)
  • University of Wisconsin-Madison (USA)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Amity University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2018, 8:9267
  • Front. Plant Sci.2022, 13:757852.
  • Anticancer Res.2018, 38(4):2127-2135
  • Nutrients.2019, 11(6):E1380
  • Evid Based Complement Alternat Med.2021, 8855980.
  • J Nat Prod.2019, 82(4):1002-1008
  • Academic J of Second Military Medical University2019, 40(1)
  • BMC Plant Biol.2022, 22(1):128.
  • Korean J. Crop Sci.2018, 63(2):131-139
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • J of L. Chroma.&Related Tech2017, 252-258
  • Oncol Lett.2020, 20(4):122.
  • Br J Pharmacol.2020, 10.1111
  • Sci Rep.2023, 13(1):13610.
  • BMC Plant Biol.2020, 20(1):214.
  • Agronomy2020, 10(10),1489
  • Dis Markers.2022, 2022:2380879.
  • Fermentation2023, 9(10), 889
  • Antioxidants (Basel).2019, 8(8):E307
  • Journal of Functional Foods2021, 84:104581
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Nutrients.2020, 12(5):1242.
  • Plants (Basel).2021, 10(7):1376.
  • ...
  • 生物活性
    Description: Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects. NI showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays. The dietary NI could prevent HFD-induced hepatic steatosis, possibly via interacting with HFD to activate Nrf2 nuclear translocation to maintain a redox status, thus regulating lipid metabolism genes expressions.
    Targets: Nrf2 | NO | SOD | GPx | CAT
    In vitro:
    Nat Prod Res. 2017 Jun;31(11):1333-1338.
    Biological activities of triterpenoids from Poraqueiba sericea stems.[Pubmed: 27736194 ]
    Eleven compounds were isolated from Poraqueiba sericea stems and identified as Niga-ichigoside F1 (1), trachelosperoside B1 (2), 4-epi-niga-ichigoside (7), 19α-hydroxyasiatic acid (3), myrianthic acid (4), hyptatic acid (5), trachelosperogenin B (6), arjunolic acid (8), and trachelosperogenin E (9), secologanoside (10) and secoxyloganin (11).
    METHODS AND RESULTS:
    Compounds 1-11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1-6 and 8-11 were tested for their cytotoxic activities on fibroblasts, 1-3, 5-6, 8-11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and 1-2, 5 and 7-10 were tested using bioautography for their β-glucosidase.
    CONCLUSIONS:
    No antileishmanial activity was detected; compounds 1, 2 and 11 showed a moderate cytotoxic activity with IC50 17.7, 20.5 and 10.9 μg/mL, respectively; compounds 2, 8, 9 and 10 gave a percentage of inhibition ranging from 13 to 16% (at 50 μg/mL) and compounds 1 and 2 showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays.
    Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1235-1244.
    Rubus imperialis (Rosaceae) extract and pure compound niga-ichigoside F1: wound healing and anti-inflammatory effects.[Pubmed: 27527496 ]
    Here, we evaluate the anti-inflammatory and wound-healing effects of methanolic crude extract obtained from aerial parts (leaves and branches) of Rubus imperialis Chum. Schl. (Rosaceae) and the pure compound niga-ichigoside F1.
    METHODS AND RESULTS:
    Anti-inflammatory activity was determined in vivo and in vitro, and the healing effect was evaluated in surgical lesions in mice skin. The 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay and H2O2-induced oxidative stress were used to determine antioxidant activity. The efferocytosis activity was also determined. The data obtained show that the extract of R. imperialis promote reduction in the inflammatory process induced by lipopolysaccharide (LPS) or carrageenan in the air pouch model; the effects could be reinforced by nitric oxide reduction in LPS-stimulated neutrophils, and an increase in the efferocytosis. The extract showed wound healing property in vitro and in vivo, scavenging activity for DPPH, and cytoprotection in the H2O2-induced oxidative stress in L929 cells. In addition, the compound niga-ichigoside F1 was able to reduce the NO secretion; however, it did not present wound-healing activity in vitro.
    CONCLUSIONS:
    Together, the data obtained point out the modulatory actions of R. imperialis extract on leukocyte migration to the inflamed tissue, the antioxidant, and the pro-resolutive activity. However, the R. imperialis anti-inflammatory activity may be mediated in parts by niga-ichigoside F1, and on wound healing do not correlated with niga-ichigoside F1.
    In vivo:
    Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):313-9.
    Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models.[Pubmed: 24402081 ]
    Previous phytochemical studies carried out with Rubus imperialis Chum. Schl. (Rosaceae) have demonstrated the presence of triterpenes (niga-ichigoside F1 and 2β,3β,19α-trihydroxyursolic acid) in this species. The literature indicates that triterpenes are closely related to some pharmacological activities, including antiulcer activity. Therefore, in view of the previous promising results with this species, this work extends the phytochemical studies, as well as investigates its gastroprotective action in different models using rodents.
    METHODS AND RESULTS:
    The hydroalcoholic extract was tested using the following protocols in mice: ethanol/HCl and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer, acetic acid-induced chronic ulcer, ligature pylorus model, and free mucus quantification in mucosa. Isolated triterpenes were investigated in the ethanol/HCl-induced ulcer model. The results of this study show that R. imperialis extract (100, 250, or 500 mg) displays gastroprotective activity in the ethanol-induced ulcer model with a percentage of inhibition of gastric lesions of 70, 71, and 86 %, respectively. The extract also significantly reduced the ulcerative lesions in the indomethacin-induced ulcer. In this model, the percentage of inhibition of ulcer was 41, 44, and 70 %, respectively. Regarding the model of gastric secretion, a reduction of gastric juice volume and total acidity was observed, as well as an increase in gastric pH; however, gastric mucus production was not altered by treatment with the extract. It was also observed that the ethyl acetate fraction presented higher activity, leading to the isolation of niga-ichigoside F1 and 2β,3β-19-α-trihydroxyursolic acid, which presented antiulcer activity comparable to that of omeprazole, with an inhibition percentage of 98 and 99 %, respectively.
    CONCLUSIONS:
    These results demonstrate that R. imperialis extract and isolated compounds (niga-ichigoside F1 and 2β,3β-19-α-trihydroxyursolic acid) produce gastroprotective effects, and this activity seems, at least in part, to be related to antisecretory effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4995 mL 7.4974 mL 14.9948 mL 29.9895 mL 37.4869 mL
    5 mM 0.2999 mL 1.4995 mL 2.999 mL 5.9979 mL 7.4974 mL
    10 mM 0.1499 mL 0.7497 mL 1.4995 mL 2.999 mL 3.7487 mL
    50 mM 0.03 mL 0.1499 mL 0.2999 mL 0.5998 mL 0.7497 mL
    100 mM 0.015 mL 0.075 mL 0.1499 mL 0.2999 mL 0.3749 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3beta-Hydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester; 3beta-Hydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester CFN95461 434942-42-4 C36H56O8 = 616.8 5mg QQ客服:2056216494
    地榆皂苷II; Ziyuglycoside II CFN98465 35286-59-0 C35H56O8 = 604.8 20mg QQ客服:3257982914
    冬青苷D; Ilexoside D CFN90993 109008-27-7 C41H66O13 = 766.97 10mg QQ客服:2159513211
    枸骨叶皂甙I; Ilexside I CFN92273 83725-19-3 C41H66O13 = 472.7 5mg QQ客服:2056216494
    冬青苷K; Ilexoside K CFN90994 109008-26-6 C47H76O18 = 929.10 10mg QQ客服:1413575084
    28-O-beta-D-吡喃葡萄糖果树酸酯; Pomolic acid 28-O-beta-D-glucopyranosyl ester CFN97328 83725-24-0 C36H58O9 = 634.9 5mg QQ客服:1457312923
    刺梨苷 F1; Kaji-ichigoside F1 CFN89311 95298-47-8 C36H58O10 = 650.85 5mg QQ客服:2056216494
    Rosamultin; Rosamultin CFN89097 88515-58-6 C36H58O10 = 650.85 20mg QQ客服:1413575084
    苦莓苷F1; Niga-ichigoside F1 CFN91060 95262-48-9 C36H58O11 = 666.9 20mg QQ客服:1457312923
    山香醇酸糖苷F1; Suavissimoside F1 CFN91067 95645-51-5 C36H56O12 = 680.8 5mg QQ客服:2159513211

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