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  • 伪原薯蓣皂苷

    Pseudoprotodioscin

    伪原薯蓣皂苷
    产品编号 CFN90694
    CAS编号 102115-79-7
    分子式 = 分子量 C51H82O2 = 1031.18
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The rhizomes of Dioscorea nipponica Makino.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    伪原薯蓣皂苷 CFN90694 102115-79-7 10mg QQ客服:1413575084
    伪原薯蓣皂苷 CFN90694 102115-79-7 20mg QQ客服:1413575084
    伪原薯蓣皂苷 CFN90694 102115-79-7 50mg QQ客服:1413575084
    伪原薯蓣皂苷 CFN90694 102115-79-7 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Universiti Sains Malaysia (Malaysia)
  • Universidad Veracuzana (Mexico)
  • Srinakharinwirot University (Thailand)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Kyushu University (Japan)
  • Melbourne University (Australia)
  • China Medical University (Taiwan)
  • Imperial College London (United Kingdom)
  • VIT University (India)
  • Amity University (India)
  • Korea Food Research Institute(KFRI) (Korea)
  • The Australian National University (Australia)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Physiologiae Plantarum2015, 37:1736
  • Acta Agriculturae Scandinavica2015, 381-383
  • Oncotarget.2015, 6(31):30831-49
  • Sci Rep.2016, 6:25094
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Food Analytical Methods2017, 10:3225–3234
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 206:327-336
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Food Quality and Safety2018, 2:213-219
  • Molecules.2018, 23(9):E2121
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Industrial Crops and Products2018, 353-362
  • Biofactors.2018, 44(2):168-179
  • Wageningen University & Research2018, January 2018
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Front Pharmacol.2019, 10:1025
  • Nutr Metab (Lond).2019, 16:31
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Planta Med.2019, 85(3):217-224
  • ...
  • 生物活性
    Description: Pseudoprotodioscin exhibits anti-inflammatory and anticancer activities, it shows a weaker suppressing effect on the production of inflammatory cytokines, and can suppress melanogenesis in B16F1 cells.
    Targets: Immunology & Inflammation related
    In vitro:
    Planta Med. 2011 May;77(7):705-10.
    Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds.[Pubmed: 20979021 ]
    Fenugreek seed ( Trigonella foenum-graecum L.) is used as an herbal medicine for treating metabolic and nutritive dysfunctions.
    METHODS AND RESULTS:
    To determine if this plant has other beneficial effects, we tested the inhibitory activities of a methanol (MeOH) extract of fenugreek seed on the production of inflammatory cytokines and melanin synthesis in cultured cell lines in vitro. The MeOH extract inhibited the production of phorbol-12-myristate-13-acetate-induced inflammatory cytokines such as tumor necrosis factor (TNF)-α in cultured THP-1 cells, and also restrained the intracellular synthesis of melanin in murine melanoma B16F1 cells. We isolated three active constituents from fenugreek seed extracts. These were identified as the steroidal saponins 26- O-β-D-glucopyranosyl-(25 R)-furost-5(6)-en-3 β,22 β,26-triol-3- O-α-L-rhamno-pyranosyl-(1'' → 2')-O-[β-D-glucopyranosyl-(1''' → 6')- O]-β-D-glucopyranoside 1, minutoside B 2, and pseudoprotodioscin 3. Compounds 1 and 2 strongly suppressed the production of inflammatory cytokines, whereas 3 showed a weaker suppressing effect. Melanogenesis in B16F1 cells was significantly suppressed by 1 and 3, and weakly suppressed by 2. All three compounds showed moderate cytotoxicities.
    CONCLUSIONS:
    These results indicate that fenugreek extract and its active constituents could protect against skin damage.
    Planta Med. 2001 Dec;67(9):853-7.
    Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity.[Pubmed: 11745024]
    Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-beta-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-beta-chacotrioside (4) and Pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill.
    METHODS AND RESULTS:
    On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside and 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranoside.
    CONCLUSIONS:
    These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9698 mL 4.8488 mL 9.6976 mL 19.3953 mL 24.2441 mL
    5 mM 0.194 mL 0.9698 mL 1.9395 mL 3.8791 mL 4.8488 mL
    10 mM 0.097 mL 0.4849 mL 0.9698 mL 1.9395 mL 2.4244 mL
    50 mM 0.0194 mL 0.097 mL 0.194 mL 0.3879 mL 0.4849 mL
    100 mM 0.0097 mL 0.0485 mL 0.097 mL 0.194 mL 0.2424 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伪原纤细薯蓣皂苷; Pseudoprotogracillin CFN93038 637349-03-2 C51H82O22 = 1047.2 5mg QQ客服:215959384
    原纤细薯蓣皂苷; Protogracillin CFN93054 54848-30-5 C51H84O23 = 1065.21 5mg QQ客服:1148253675
    甲基原纤细薯蓣皂苷; Methyl protogracillin CFN80084 54522-53-1 C52H86O23 = 1078.55 5mg QQ客服:215959384
    重楼皂苷G; Polyphyllin G CFN99955 76296-75-8 C51H84O22 = 1049.22 20mg QQ客服:1148253675
    原皂苷Pa; Parisaponin I CFN90702 561007-63-4 C50H82O22 = 1034.0 5mg QQ客服:1148253675
    原皂苷Pb; Dichotomin CFN90703 53093-47-3 C57H94O26 = 1195.34 5mg QQ客服:2159513211
    知母皂苷B; Anemarsaponin B CFN99532 139051-27-7 C45H74O18 = 903.04 20mg QQ客服:215959384
    知母皂苷BIII; Anemarsaponin BIII CFN90778 142759-74-8 C45H74O18 = 903.1 5mg QQ客服:2932563308
    知母皂苷C; Timorsaponin C CFN90779 185432-00-2 C45H74O18 = 903.1 5mg QQ客服:1148253675
    伪原皂苷Pa; Parisyunnanoside B CFN90704 945865-37-2 C50H80O21 = 1016.0 5mg QQ客服:2932563308

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