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  • 甲基原纤细薯蓣皂苷

    Methyl protogracillin

    甲基原纤细薯蓣皂苷
    产品编号 CFN80084
    CAS编号 54522-53-1
    分子式 = 分子量 C52H86O23 = 1078.55
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Dioscorea opposita Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甲基原纤细薯蓣皂苷 CFN80084 54522-53-1 1mg QQ客服:3257982914
    甲基原纤细薯蓣皂苷 CFN80084 54522-53-1 5mg QQ客服:3257982914
    甲基原纤细薯蓣皂苷 CFN80084 54522-53-1 10mg QQ客服:3257982914
    甲基原纤细薯蓣皂苷 CFN80084 54522-53-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite de Lille1 (France)
  • Monash University Malaysia (Malaysia)
  • Michigan State University (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of Malaya (Malaysia)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Wageningen University (Netherlands)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Medical University of South Carolina (USA)
  • University of the Basque Country (Spain)
  • Biotech R&D Institute (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Int J Mol Sci.2015, 16(8):18396-411
  • Int J Mol Med.2015, 35(5):1237-45
  • Acta Physiologiae Plantarum2015, 37:1736
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Research on Crops.2017, 18(2)
  • Preprints2017, 2017120176
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • J Nat Med.2017, 71(2):380-388
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • International Food Research Journal2018, 25(6):2560-2571
  • Nat Commun.2019, 10(1):5169
  • World J Mens Health.2019, 10.5534
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(10):E1926
  • Molecules.2019, 24(24):E4536
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Food Chem.2019, 274:345-350
  • Journal of Functional Foods2019, 52:430-441
  • J Mater Chem B.2019, 7(39):5896-5919
  • ...
  • 生物活性
    Description: Methyl protoneogracillin shows cytotoxic activitiy against the cancer cell line of K562 in vitro as antineoplastic agents. It can cause morphological abnormality of Pyricularia oryzae mycelia.
    Targets: Antifection
    In vitro:
    Phytother Res. 2003 Jun;17(6):620-6.
    The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro.[Pubmed: 12820229]
    In our continuous studies of anticancer activity of steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca (Dioscoreaceae), methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787) were tested for cytotoxicity against human cancer cell lines from leukemia and eight solid tumor diseases.
    METHODS AND RESULTS:
    As a result, methyl protoneogracillin was cytotoxic against all the test cell lines with GI(50) < 100 micro M, especially selectively against two leukemia lines (CCRF-CEM and RPMT-8226), one colon cancer line (KM12), two central nervous system (CNS) cancer lines (SF-539 and U251), one melanoma line (M14), one renal cancer line (786-0), one prostate cancer line (DU-145), and one breast cancer line (MDA-MB-435), with GI(50) < or = 2.0 micro M. Leukemia, CNS cancer, and prostate cancer were the most sensitive subpanels, while ovarian cancer was the least sensitive subpanels. The preliminary toxicity studies showed that the maximum tolerant dose was 600 mg/kg for methyl protoneogracillin to mice. Gracillin was cytotoxic against most cell lines with GI(50), TGI and LC(50) at micromolar levels, but no activity against EKVX (non-small cell lung cancer), HT29 (colon cancer), OVCAR-5 (ovarian cancer), and SN12C (renal cancer). Based on structure-activity relationship, C-25 R/S con fi guration was critical for leukemia selectivity between methyl protoneogracillin and Methyl protogracillin. F-ring was critical to selectivity between furostanol (methyl protoneogracillin and Methyl protogracillin) and spirostanol (gracillin) saponins in this study.
    CONCLUSIONS:
    By an analysis of COMPARE software, no compounds in the NCI's database had similar mean graphs to those of methyl protoneogracillin and gracillin, respectively, indicating potential novel mechanism(s) of action involved. Put all in together, methyl protoneogracillin has been selected as a potential anticancer candidate for hollow fi ber assay to nude mice, but gracillin will not be pursued due to lack of selectivity against human cancer diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9272 mL 4.6359 mL 9.2717 mL 18.5434 mL 23.1793 mL
    5 mM 0.1854 mL 0.9272 mL 1.8543 mL 3.7087 mL 4.6359 mL
    10 mM 0.0927 mL 0.4636 mL 0.9272 mL 1.8543 mL 2.3179 mL
    50 mM 0.0185 mL 0.0927 mL 0.1854 mL 0.3709 mL 0.4636 mL
    100 mM 0.0093 mL 0.0464 mL 0.0927 mL 0.1854 mL 0.2318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伪原皂苷Pb; Pseudoproto Pb CFN90705 102100-46-9 C57H92O25 = 1177.4 5mg QQ客服:2932563308
    新知母皂苷BII; Officinalisinin I CFN90692 57944-18-0 C45H76O19 = 921.07 20mg QQ客服:2932563308
    知母皂苷E; Anemarsaponin E CFN99533 136565-73-6 C46H78O19 = 934.03 10mg QQ客服:1413575084
    原薯蓣皂苷; Protodioscin CFN99517 55056-80-9 C51H84O22 = 1049.21 20mg QQ客服:3257982914
    甲基原薯蓣皂苷; Methyl protodioscin CFN99585 54522-52-0 C52H86O22 = 1063.23 20mg QQ客服:1413575084
    原翠雀皂苷; Protodeltonin CFN93008 94992-08-2 C51H84O23 = 1065.21 5mg QQ客服:1148253675
    伪原纤细薯蓣皂苷; Pseudoprotogracillin CFN93038 637349-03-2 C51H82O22 = 1047.2 5mg QQ客服:2159513211
    原纤细薯蓣皂苷; Protogracillin CFN93054 54848-30-5 C51H84O23 = 1065.21 5mg QQ客服:2932563308
    甲基原纤细薯蓣皂苷; Methyl protogracillin CFN80084 54522-53-1 C52H86O23 = 1078.55 5mg QQ客服:3257982914
    重楼皂苷G; Polyphyllin G CFN99955 76296-75-8 C51H84O22 = 1049.22 20mg QQ客服:1413575084

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