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    Polyphyllin G

    产品编号 CFN99955
    CAS编号 76296-75-8
    分子式 = 分子量 C51H84O22 = 1049.22
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The rhizomes of Paris yunnanensis Franch.
    产品名称 产品编号 CAS编号 包装 QQ客服
    重楼皂苷G CFN99955 76296-75-8 10mg QQ客服:3257982914
    重楼皂苷G CFN99955 76296-75-8 20mg QQ客服:3257982914
    重楼皂苷G CFN99955 76296-75-8 50mg QQ客服:3257982914
    重楼皂苷G CFN99955 76296-75-8 100mg QQ客服:3257982914
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  • 生物活性
    Description: Polyphyllin G has been shown to have strong anticancer activities in a wide variety of human cancer cell lines, it also shows significant anthelmintic activity against Dactylogyrus intermedius with EC50 values of 1.2 mg L(-1) and the acute toxicities (LC50) values of 2.9 mg L(-1).
    Targets: Caspase | Bcl-2/Bax | Akt | ERK | JNK | p38MAPK | Autophagy | Antifection
    In vitro:
    Phytomedicine. 2016 Dec 1;23(13):1545-1554.
    Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells.[Pubmed: 27823618]
    Polyphyllin G (also called polyphyllin VII), extract from rhizomes of Paris yunnanensis Franch, has been shown to have strong anticancer activities in a wide variety of human cancer cell lines. However, the underlying influences of autophagy in human oral squamous cell carcinoma (OSCC) remain unclear.
    In this study, the roles of apoptosis and autophagy in polyphyllin G-induced death in human oral cancer cells were investigated. Moreover, the molecular mechanism of the anticancer effects of polyphyllin G in human oral cancer cells was investigated. The results revealed that polyphyllin G significantly inhibited cell proliferation in human oral cancer cells; it dose-dependently induced apoptosis in SAS and OECM-1 cells through caspase-3, -8, and -9 activation and poly (ADP-ribose) polymerase cleavage. In addition, changes were observed in Bcl-2 and proapoptosis-related protein expression in different human oral cancer cell lines. The expression of both LC3-II and beclin-1 was markedly increased, suggesting the induction of autophagy in polyphyllin G-treated oral cells. To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors. The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.
    This study is the first to demonstrate apoptosis and autophagy during polyphyllin G-induced cell death in human oral cancer cell lines. These results suggest that polyphyllin G is a promising candidate for developing antitumor drugs targeting human oral squamous cell carcinoma.
    In vivo:
    Parasitology. 2013 Jul;140(8):952-8.
    Identification of compounds from Paris polyphylla (ChongLou) active against Dactylogyrus intermedius.[Pubmed: 23552446]
    The present study was designated to ascertain the anthelmintic activity of the rhizomes of Paris polyphylla and to isolate and characterize the active constituents.
    The methanol extract from rhizomes of P. polyphylla showed significant anthelmintic activity against Dactylogyrus intermedius with the median effective concentration (EC50) 22.5 mg L(-1). Based on this finding, the methanol extract was fractionated by silica gel column chromatography in a bioassay-guided fractionation yielding 2 bioactive compounds, the structures of these compounds were elucidated as formosanin C and polyphyllin VII(Polyphyllin G). The in vivo tests revealed that formosanin C and polyphyllin VII were significantly effective against D. intermedius with EC50 values of 0.6 and 1.2 mg L(-1), respectively. The acute toxicities (LC50) of formosanin C and polyphyllin VII for grass carp were 2.8 and 2.9 mg L(-1), respectively.
    The overall results provide important information for the potential application of formosanin C and polyphyllin VII in the therapy of serious infection caused by D. intermedius.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9531 mL 4.7654 mL 9.5309 mL 19.0618 mL 23.8272 mL
    5 mM 0.1906 mL 0.9531 mL 1.9062 mL 3.8124 mL 4.7654 mL
    10 mM 0.0953 mL 0.4765 mL 0.9531 mL 1.9062 mL 2.3827 mL
    50 mM 0.0191 mL 0.0953 mL 0.1906 mL 0.3812 mL 0.4765 mL
    100 mM 0.0095 mL 0.0477 mL 0.0953 mL 0.1906 mL 0.2383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    知母皂苷B; Anemarsaponin B CFN99532 139051-27-7 C45H74O18 = 903.04 20mg QQ客服:1148253675
    知母皂苷BIII; Anemarsaponin BIII CFN90778 142759-74-8 C45H74O18 = 903.1 5mg QQ客服:1148253675
    知母皂苷C; Timorsaponin C CFN90779 185432-00-2 C45H74O18 = 903.1 5mg QQ客服:215959384
    伪原皂苷Pa; Parisyunnanoside B CFN90704 945865-37-2 C50H80O21 = 1016.0 5mg QQ客服:2932563308
    伪原薯蓣皂苷; Pseudoprotodioscin CFN90694 102115-79-7 C51H82O2 = 1031.18 20mg QQ客服:2932563308
    蒺藜皂苷K; Terrestrosin K CFN90822 193605-07-1 C51H82O24 = 1079.2 10mg QQ客服:2932563308
    伪原皂苷Pb; Pseudoproto Pb CFN90705 102100-46-9 C57H92O25 = 1177.4 5mg QQ客服:2159513211
    新知母皂苷BII; Officinalisinin I CFN90692 57944-18-0 C45H76O19 = 921.07 20mg QQ客服:1148253675
    知母皂苷E; Anemarsaponin E CFN99533 136565-73-6 C46H78O19 = 934.03 10mg QQ客服:215959384
    原薯蓣皂苷; Protodioscin CFN99517 55056-80-9 C51H84O22 = 1049.21 20mg QQ客服:2159513211





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