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  • 原纤细薯蓣皂苷

    Protogracillin

    原纤细薯蓣皂苷
    产品编号 CFN93054
    CAS编号 54848-30-5
    分子式 = 分子量 C51H84O23 = 1065.21
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Dioscorea opposita Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    原纤细薯蓣皂苷 CFN93054 54848-30-5 1mg QQ客服:215959384
    原纤细薯蓣皂苷 CFN93054 54848-30-5 5mg QQ客服:215959384
    原纤细薯蓣皂苷 CFN93054 54848-30-5 10mg QQ客服:215959384
    原纤细薯蓣皂苷 CFN93054 54848-30-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Toronto (Canada)
  • Medical University of Gdansk (Poland)
  • University of Hertfordshire (United Kingdom)
  • Chungnam National University (Korea)
  • Charles Sturt University (Denmark)
  • Mendel University in Brno (Czech Republic)
  • University of Parma (Italy)
  • Griffith University (Australia)
  • Weizmann Institute of Science (Israel)
  • Texas A&M University (USA)
  • Siksha O Anusandhan University (India)
  • The Ohio State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci. Rep.2015, 14-23
  • Phytomedicine.2015, 22(14):1262-8
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Chem Biol Interact.2016, 258:59-68
  • Acta horticulturae2017, 1158:257-268
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Journal of Functional Foods2017, 30:30-38
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Nat Commun.2019, 10(1):5169
  • Biorxiv2019, 10.1101
  • Nutrients.2019, 11(4):E936
  • Molecules.2019, 24(10):E1926
  • Molecules.2019, 24(6):E1155
  • J Ethnopharmacol.2019, 241:112025
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Phytother Res.2019, 33(5):1490-1500
  • FASEB J.2019, 33(8):9685-9694
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Psychopharmacology (Berl).2020, 10.1007
  • Food Analytical Methods2020, 1-10
  • United States Patent Application2020, 20200038363
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Protogracillin may have inhibitions on platelet aggregation (PAG) and thrombosis.
    In vitro:
    Anticancer Agents Med Chem. 2014;14(6):833-9.
    Paris polyphylla: chemical and biological prospectives.[Pubmed: 24917072]
    Paris polyphylla J.E. Smith is extensively used in traditional systems of Indian and Chinese medicines mainly for its anticancerous property. The national and international demand for P. polyphylla is constantly increasing and most of the supplies come from wild. Illegal and unscientific exploitation coupled with habitat destruction decreases the natural population of the herb, as a consequence this species comes under vulnerable category. Restoration and conservation of the natural population of this potential herb is prerequisites.
    METHODS AND RESULTS:
    This article aims to provide an overview on chemical and biological prospective of P. polyphylla. Secondary metabolites such as daucosterol, polyphyllin D, β -ecdysterone, Paris saponins I, II, V, VI, VII, H, dioscin, oligosaccharides, heptasaccharide, octasaccharide, trigofoenoside A, Protogracillin, Paris yunnanosides G-J, padelaoside B, pinnatasterone, formosanin C and 20-hydroxyecdyson saponins have been isolated from P. polyphylla. Several biological activities such as anticancerous, antitumor, cytotoxic, anthelmintic, antimicrobial, antiangiogenic, immunostimulating, contractile and hemostatic have also been reported.
    CONCLUSIONS:
    Consequently, this review will be helpful to the researcher and scientist for further research.
    In vivo:
    Fitoterapia. 2010 Dec;81(8):1147-56.
    Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.[Pubmed: 20659537 ]
    Steroidal saponins have long attracted scientific attention, due to their structural diversity and significant biological activities. Total steroidal saponins (TSS) extracted from the rhizomes of Dioscorea zingiberensis C.H. Wright (DZW) constitute an effective treatment for cardiovascular disease. However, the active constituents contained in DZW rhizomes and their pharmacological properties are not fully understood. The aim of this work is to determine and quantify the active constituents in DZW rhizomes using fingerprint technique, and evaluate its anti-thrombotic activity using inferior vena cava ligation thrombosis rat model and pulmonary thrombosis mice model after being gavaged with TSS for 1 or 2weeks.
    METHODS AND RESULTS:
    In the study, a chemical fingerprint method was firstly established and validated to quantify and standardize TSS from DZW rhizomes including parvifloside, protodeltonin, protodioscin, Protogracillin, zingiberensis saponin, deltonin, dioscin and trillin. TSS extracted from DZW rhizomes were showed to have the inhibitions on platelet aggregation (PAG) and thrombosis, and prolong activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT) in a dose-dependent manner in rats. TSS also prolonged the bleeding time and clotting time in a dose-dependent manner in mice.
    CONCLUSIONS:
    The results indicate that TSS could inhibit thrombosis by both improving the anticoagulation activity and inhibiting PAG action, suggesting that TSS from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9388 mL 4.6939 mL 9.3878 mL 18.7756 mL 23.4696 mL
    5 mM 0.1878 mL 0.9388 mL 1.8776 mL 3.7551 mL 4.6939 mL
    10 mM 0.0939 mL 0.4694 mL 0.9388 mL 1.8776 mL 2.347 mL
    50 mM 0.0188 mL 0.0939 mL 0.1878 mL 0.3755 mL 0.4694 mL
    100 mM 0.0094 mL 0.0469 mL 0.0939 mL 0.1878 mL 0.2347 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    知母皂苷E; Anemarsaponin E CFN99533 136565-73-6 C46H78O19 = 934.03 10mg QQ客服:215959384
    原薯蓣皂苷; Protodioscin CFN99517 55056-80-9 C51H84O22 = 1049.21 20mg QQ客服:3257982914
    甲基原薯蓣皂苷; Methyl protodioscin CFN99585 54522-52-0 C52H86O22 = 1063.23 20mg QQ客服:2932563308
    原翠雀皂苷; Protodeltonin CFN93008 94992-08-2 C51H84O23 = 1065.21 5mg QQ客服:1413575084
    伪原纤细薯蓣皂苷; Pseudoprotogracillin CFN93038 637349-03-2 C51H82O22 = 1047.2 5mg QQ客服:2932563308
    原纤细薯蓣皂苷; Protogracillin CFN93054 54848-30-5 C51H84O23 = 1065.21 5mg QQ客服:215959384
    甲基原纤细薯蓣皂苷; Methyl protogracillin CFN80084 54522-53-1 C52H86O23 = 1078.55 5mg QQ客服:3257982914
    重楼皂苷G; Polyphyllin G CFN99955 76296-75-8 C51H84O22 = 1049.22 20mg QQ客服:1413575084
    原皂苷Pa; Parisaponin I CFN90702 561007-63-4 C50H82O22 = 1034.0 5mg QQ客服:215959384
    原皂苷Pb; Dichotomin CFN90703 53093-47-3 C57H94O26 = 1195.34 5mg QQ客服:1148253675

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