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    产品编号 CFN93054
    CAS编号 54848-30-5
    分子式 = 分子量 C51H84O23 = 1065.21
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Dioscorea opposita Thunb.
    产品名称 产品编号 CAS编号 包装 QQ客服
    原纤细薯蓣皂苷 CFN93054 54848-30-5 1mg QQ客服:2159513211
    原纤细薯蓣皂苷 CFN93054 54848-30-5 5mg QQ客服:2159513211
    原纤细薯蓣皂苷 CFN93054 54848-30-5 10mg QQ客服:2159513211
    原纤细薯蓣皂苷 CFN93054 54848-30-5 20mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • ...
  • 生物活性
    Description: Protogracillin may have inhibitions on platelet aggregation (PAG) and thrombosis.
    In vitro:
    Anticancer Agents Med Chem. 2014;14(6):833-9.
    Paris polyphylla: chemical and biological prospectives.[Pubmed: 24917072]
    Paris polyphylla J.E. Smith is extensively used in traditional systems of Indian and Chinese medicines mainly for its anticancerous property. The national and international demand for P. polyphylla is constantly increasing and most of the supplies come from wild. Illegal and unscientific exploitation coupled with habitat destruction decreases the natural population of the herb, as a consequence this species comes under vulnerable category. Restoration and conservation of the natural population of this potential herb is prerequisites.
    This article aims to provide an overview on chemical and biological prospective of P. polyphylla. Secondary metabolites such as daucosterol, polyphyllin D, β -ecdysterone, Paris saponins I, II, V, VI, VII, H, dioscin, oligosaccharides, heptasaccharide, octasaccharide, trigofoenoside A, Protogracillin, Paris yunnanosides G-J, padelaoside B, pinnatasterone, formosanin C and 20-hydroxyecdyson saponins have been isolated from P. polyphylla. Several biological activities such as anticancerous, antitumor, cytotoxic, anthelmintic, antimicrobial, antiangiogenic, immunostimulating, contractile and hemostatic have also been reported.
    Consequently, this review will be helpful to the researcher and scientist for further research.
    In vivo:
    Fitoterapia. 2010 Dec;81(8):1147-56.
    Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.[Pubmed: 20659537 ]
    Steroidal saponins have long attracted scientific attention, due to their structural diversity and significant biological activities. Total steroidal saponins (TSS) extracted from the rhizomes of Dioscorea zingiberensis C.H. Wright (DZW) constitute an effective treatment for cardiovascular disease. However, the active constituents contained in DZW rhizomes and their pharmacological properties are not fully understood. The aim of this work is to determine and quantify the active constituents in DZW rhizomes using fingerprint technique, and evaluate its anti-thrombotic activity using inferior vena cava ligation thrombosis rat model and pulmonary thrombosis mice model after being gavaged with TSS for 1 or 2weeks.
    In the study, a chemical fingerprint method was firstly established and validated to quantify and standardize TSS from DZW rhizomes including parvifloside, protodeltonin, protodioscin, Protogracillin, zingiberensis saponin, deltonin, dioscin and trillin. TSS extracted from DZW rhizomes were showed to have the inhibitions on platelet aggregation (PAG) and thrombosis, and prolong activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT) in a dose-dependent manner in rats. TSS also prolonged the bleeding time and clotting time in a dose-dependent manner in mice.
    The results indicate that TSS could inhibit thrombosis by both improving the anticoagulation activity and inhibiting PAG action, suggesting that TSS from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9388 mL 4.6939 mL 9.3878 mL 18.7756 mL 23.4696 mL
    5 mM 0.1878 mL 0.9388 mL 1.8776 mL 3.7551 mL 4.6939 mL
    10 mM 0.0939 mL 0.4694 mL 0.9388 mL 1.8776 mL 2.347 mL
    50 mM 0.0188 mL 0.0939 mL 0.1878 mL 0.3755 mL 0.4694 mL
    100 mM 0.0094 mL 0.0469 mL 0.0939 mL 0.1878 mL 0.2347 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蒺藜皂苷K; Terrestrosin K CFN90822 193605-07-1 C51H82O24 = 1079.2 10mg QQ客服:215959384
    伪原皂苷Pb; Pseudoproto Pb CFN90705 102100-46-9 C57H92O25 = 1177.4 5mg QQ客服:1413575084
    新知母皂苷BII; Officinalisinin I CFN90692 57944-18-0 C45H76O19 = 921.07 20mg QQ客服:215959384
    知母皂苷E; Anemarsaponin E CFN99533 136565-73-6 C46H78O19 = 934.03 10mg QQ客服:215959384
    原薯蓣皂苷; Protodioscin CFN99517 55056-80-9 C51H84O22 = 1049.21 20mg QQ客服:2932563308
    甲基原薯蓣皂苷; Methyl protodioscin CFN99585 54522-52-0 C52H86O22 = 1063.23 20mg QQ客服:215959384
    原翠雀皂苷; Protodeltonin CFN93008 94992-08-2 C51H84O23 = 1065.21 5mg QQ客服:3257982914
    伪原纤细薯蓣皂苷; Pseudoprotogracillin CFN93038 637349-03-2 C51H82O22 = 1047.2 5mg QQ客服:215959384
    原纤细薯蓣皂苷; Protogracillin CFN93054 54848-30-5 C51H84O23 = 1065.21 5mg QQ客服:2932563308
    甲基原纤细薯蓣皂苷; Methyl protogracillin CFN80084 54522-53-1 C52H86O23 = 1078.55 5mg QQ客服:2159513211





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