• 中药标准品生产商,产品定制服务
  • 氧化前胡素

    Oxypeucedanin

    氧化前胡素
    产品编号 CFN90350
    CAS编号 737-52-0
    分子式 = 分子量 C16H14O5 = 286.28
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氧化前胡素 CFN90350 737-52-0 10mg QQ客服:215959384
    氧化前胡素 CFN90350 737-52-0 20mg QQ客服:215959384
    氧化前胡素 CFN90350 737-52-0 50mg QQ客服:215959384
    氧化前胡素 CFN90350 737-52-0 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Eastern Finland (Finland)
  • Seoul National University of Science and Technology (Korea)
  • Complutense University of Madrid (Spain)
  • Kamphaengphet Rajabhat University (Thailand)
  • Center for protein Engineering (CIP) (Belgium)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Ateneo de Manila University (Philippines)
  • Copenhagen University (Denmark)
  • Chungnam National University (Korea)
  • University Medical Center Mainz (Germany)
  • S.N.D.T. Women's University (India)
  • Harvard University (USA)
  • Tohoku University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • J. of Agricultural Science2015, 1916-9760
  • Phytother Res.2015, 29(7):1088-96
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Free Radic Biol Med.2016, 97:307-319
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Molecules.2018, 23(10):E2638
  • Molecules.2018, 23(7):E1659
  • Curr Eye Res.2018, 43(1):27-34
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Cell Death Dis.2019, 10(12):882
  • Front Aging Neurosci.2019, 11:230
  • Plant Physiol Biochem.2019, 144:355-364
  • J Ethnopharmacol.2019, 235:406-414
  • Molecules.2019, 24(6):E1155
  • Cell Chem Biol.2019, 26(1):27-34
  • Chem Biol Interact.2019, 298:1-7
  • Environ Toxicol.2019, 34(4):513-520.
  • J Sep Sci.2019, 42(21):3352-3362
  • J Nat Prod.2019, 82(4):1002-1008
  • Appl. Sci.2020, 10,1304
  • Food and Chemical Toxicology2020, 111221
  • Antioxidants (Basel).2020, 9(2):E99
  • ...
  • 生物活性
    Description: Oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.Oxypeucedanin has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells.
    Targets: ERK | p38MAPK | PPAR | hKv1.5 channel | Caspase
    In vitro:
    Planta Med. 2011 Sep;77(13):1512-8.
    Effects of oxypeucedanin on global gene expression and MAPK signaling pathway in mouse neuroblastoma Neuro-2A cells.[Pubmed: 21425034]
    Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. Coumarin aglycones have demonstrated various pharmacological effects, including anti-proliferation, anti-inflammation, and anti-pain.
    METHODS AND RESULTS:
    In this study, in order to understand the pharmacological properties of Oxypeucedanin, we investigated global gene expression alteration in mouse neuroblastoma Neuro-2A cells. Results from the MTT assay indicated no decrease of cell viability up to 100 μM for 24 h. We measured gene expression profiles in Neuro-2A cells treated with either 10 μM or no Oxypeucedanin for 24 h. We selected 128 differentially expressed genes (DEGs) for comparison of gene expression profiles by Bonferroni-adjusted p values (p < 0.1). Analysis of Gene Ontology (GO) biological process terms using the DEGs demonstrated the importance of protein metabolism, particularly ribosomal protein synthesis and protein degradation, intramembrane protein trafficking, and electron transport. Treatment with Oxypeucedanin resulted in the downregulation of most DEGs for ribosomal protein synthesis and the electron transport chain (ETC). In contrast, most DEGs for protein degradation and cellular trafficking systems were upregulated. In addition, we found five upregulated DEGs for core and regulatory proteins involved in the mitogen-activated protein kinase (MAPK) signaling pathway. Independent translational validation of DEGs for MAPK signaling by immunoblot analysis showed consistent agreement with microarray data. Overall protein levels of Erk2 and p38MAPK were elevated, and their phosphorylated forms were also increased.
    CONCLUSIONS:
    These functional categories, based on transcriptional alteration and complicated modulation of MAPK signaling, might be underlying mechanisms responsible for the various pharmacological effects of Oxypeucedanin.
    Biol Pharm Bull. 2005 Apr;28(4):657-60.
    Effects of oxypeucedanin on hKv1.5 and action potential duration.[Pubmed: 15802805]

    METHODS AND RESULTS:
    A furocoumarin derivative, oxypeucedanin, was purified from Angelica dahurica, and its effects on the human Kv1.5 (hKv1.5) channel and on the cardiac action potential duration (APD), were examined using the patch-clamp technique and the conventional microelectrode technique. Oxypeucedanin inhibited the hKv1.5 current in a concentration-dependent manner, with an IC(50) value of 76 nM, while it had no effect on human eag-related gene (HERG) current. Oxypeucedanin induced an initial fast decline of hKv1.5 current during depolarizations. The inhibition of hKv1.5 channel by oxypeucedanin was voltage-dependent, especially at depolarizing pulses between -40 and 0 mV which corresponds to the voltage range of the channel's opening. Oxypeucedanin also slowed the deactivation time course, resulting in a tail crossover phenomenon. Additionally, oxypeucedanin prolonged the APD of rat atrial and ventricular muscles in a dose-dependent manner.
    CONCLUSIONS:
    These results suggest that oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD; therefore, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.
    In vivo:
    Pharmacol Rep. 2010 Nov-Dec;62(6):1231-6.
    Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study.[Pubmed: 21273683]
    The aim of this study was to determine and compare the anticonvulsant activities of four natural furanocoumarins [bergapten (5-methoxypsoralen), imperatorin (8-isopentenyloxypsoralen), Oxypeucedanin (5-epoxy-isopentenyloxypsoralen) and xanthotoxin (8-methoxypsoralen)] in the maximal electroshock-induced seizure test in mice.
    METHODS AND RESULTS:
    The anticonvulsant effects of bergapten, imperatorin, Oxypeucedanin, and xanthotoxin were evaluated at 15, 30, 60 and 120 min after their systemic (intraperitoneal) administration. Tonic hind limb extension (seizure activity) was evoked in adult albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via auricular electrodes. The time courses of protection by bergapten, imperatorin, Oxypeucedanin and xanthotoxin against maximal electroshock-induced seizures revealed that 300 mg/kg imperatorin and xanthotoxin (C-8 substituted derivatives of psoralen) exerted strong anticonvulsant activity, whereas 300 mg/kg bergapten and Oxypeucedanin (C-5 substituted derivatives of psoralen) did not produce any anticonvulsant activity in this model.
    CONCLUSIONS:
    In conclusion, imperatorin and xanthotoxin protected the animals against maximal electroshock-induced seizures, whereas bergapten and Oxypeucedanin, despite their chemical and structural similarities to xanthotoxin and imperatorin, exerted no anticonvulsant activity in this seizure test.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4931 mL 17.4654 mL 34.9308 mL 69.8617 mL 87.3271 mL
    5 mM 0.6986 mL 3.4931 mL 6.9862 mL 13.9723 mL 17.4654 mL
    10 mM 0.3493 mL 1.7465 mL 3.4931 mL 6.9862 mL 8.7327 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3972 mL 1.7465 mL
    100 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.6986 mL 0.8733 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6',7'-二羟薄荷素缩丙酮; 6',7'-Dihydroxybergamottin acetonide CFN97165 684217-08-1 C24H28O6 = 412.5 5mg QQ客服:1148253675
    6'-羟基-7'-乙氧基香柠檬亭; 6'-Hydroxy-7'-ethoxybergamottin CFN97583 N/A C23H28O6 = 400.5 5mg QQ客服:2932563308
    8-氧甲基异欧前胡内酯; Cnidilin CFN90590 14348-22-2 C17H16O5 = 300.31 10mg QQ客服:215959384
    氧化前胡素; Oxypeucedanin CFN90350 737-52-0 C16H14O5 = 286.28 20mg QQ客服:1413575084
    水合氧化前胡素; Oxypeucedanin hydrate CFN90557 2643-85-8 C16H16O6 = 304.29 20mg QQ客服:3257982914
    佛手柑素; Bergamotine CFN90592 7380-40-7 C21H22O4 = 338.4 10mg QQ客服:1148253675
    羌活醇; Notopterol CFN98563 88206-46-6 C21H22O5 = 354.40 20mg QQ客服:3257982914
    羌活酚; Notoptol CFN95218 88206-49-9 C21H22O5 = 354.4 5mg QQ客服:1148253675
    环氧香柠檬素; Epoxybergamottin CFN70306 206978-14-5 C21H22O5 = 354.4 5mg QQ客服:1148253675
    6',7'-二羟薄荷素; 6',7'-Dihydroxybergamottin CFN98307 264234-05-1 C21H24O6 = 372.4 10mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产