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  • 8-氧甲基异欧前胡内酯

    Cnidilin

    8-氧甲基异欧前胡内酯
    产品编号 CFN90590
    CAS编号 14348-22-2
    分子式 = 分子量 C17H16O5 = 300.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    8-氧甲基异欧前胡内酯 CFN90590 14348-22-2 1mg QQ客服:2159513211
    8-氧甲基异欧前胡内酯 CFN90590 14348-22-2 5mg QQ客服:2159513211
    8-氧甲基异欧前胡内酯 CFN90590 14348-22-2 10mg QQ客服:2159513211
    8-氧甲基异欧前胡内酯 CFN90590 14348-22-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Instituto Politécnico de Bragan?a (Portugal)
  • Julius Kühn-Institut (Germany)
  • Florida International University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Fitoterapia.2015, 100:179-86
  • Int J Mol Sci.2015, 16(8):18396-411
  • Acta Agriculturae Scandinavica2015, 381-383
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • SBRAS2016, 12
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Eur J Pharm Sci.2016, 94:33-45
  • Sci Rep. 2017, 12953(7)
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Yakugaku Zasshi.2018, 138(4):571-579
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Cell.2018, 172(1-2):249-261
  • Molecules.2018, 23(7):E1817
  • Pak J Pharm Sci.2018, 31:311-315
  • Anticancer Res.2018, 38(4):2127-2135
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • J Ethnopharmacol.2019, 244:112074
  • J of Dentistry & Oral Health2019, 2641-1962
  • J Sep Sci.2019, 42(21):3352-3362
  • Int J Oncol.2019, 55(1):320-330
  • Sci Rep.2019, 9(1):18080
  • ...
  • 生物活性
    Description: Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous system diseases.
    Targets: P-gp
    In vitro:
    Fitoterapia. 2013 Mar;85:144-53.
    In vitro permeability analysis, pharmacokinetic and brain distribution study in mice of imperatorin, isoimperatorin and cnidilin in Radix Angelicae Dahuricae.[Pubmed: 23353658]
    Coumarins are important constituents of Radix Angelicae Dahuricae, a well-known traditional Chinese medicine possess several known bioactivities with potentials in the treatment of central nervous system diseases.
    METHODS AND RESULTS:
    By using an HPLC-MS/MS method, we analyzed the in vivo plasma and brain pharmacokinetics of three ingredients of coumarins, including imperatorin, isoimperatorin and cnidilin in mice after oral administration of Dahuricae extract at doses of 800mg/kg. The biosamples were prepared using acetonitrile precipitation and the separation was achieved on an XDB-C18 column by gradient elution. The BBB permeability and P-gp-mediated efflux were further examined in Madin Canine kidney cells transfected with full length cDNA for human multidrug resistance gene1 (MDCKII-MDR1). Our results demonstrate that the method has excellent and satisfactory selectivity, sensitivity, linearity, precision, and accuracy for simultaneous determination of imperatorin, isoimperatorin and cnidilin. The pharmacokinetics parameters were determined by using noncompartmental analyses, including the AUC(0-t) in plasma (1695.22, 1326.45 and 636.98mg*h/L), the AUC(0-t) in brain (1812.35, 2125.17 and 1145.83ng*h/g) as well as the T1/2 in plasma (0.66, 0.82, 0.97h) and brain (0.96, 1.1, 0.99h) for imperatorin, isoimperatorin and cnidilin, respectively, suggesting that the three coumarins could easily pass through the BBB in vivo. In the in vitro model we observed high permeability of imperatorin and isoimperatorin with the P-gp-mediated efflux ratios of 0.53 and 0.06, as well as medium permeability of cnidilin with 0.82.
    CONCLUSIONS:
    All data suggest that these three coumarins have high BBB permeability and have pharmacokinetic potentials for the treatment of central nervous system diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3299 mL 16.6495 mL 33.2989 mL 66.5978 mL 83.2473 mL
    5 mM 0.666 mL 3.3299 mL 6.6598 mL 13.3196 mL 16.6495 mL
    10 mM 0.333 mL 1.6649 mL 3.3299 mL 6.6598 mL 8.3247 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.6649 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    羌活醇; Notopterol CFN98563 88206-46-6 C21H22O5 = 354.40 20mg QQ客服:3257982914
    羌活酚; Notoptol CFN95218 88206-49-9 C21H22O5 = 354.4 5mg QQ客服:2932563308
    环氧香柠檬素; Epoxybergamottin CFN70306 206978-14-5 C21H22O5 = 354.4 5mg QQ客服:215959384
    6',7'-二羟薄荷素; 6',7'-Dihydroxybergamottin CFN98307 264234-05-1 C21H24O6 = 372.4 10mg QQ客服:1148253675
    6',7'-二羟薄荷素缩丙酮; 6',7'-Dihydroxybergamottin acetonide CFN97165 684217-08-1 C24H28O6 = 412.5 5mg QQ客服:2932563308
    6'-羟基-7'-乙氧基香柠檬亭; 6'-Hydroxy-7'-ethoxybergamottin CFN97583 N/A C23H28O6 = 400.5 5mg QQ客服:2932563308
    8-氧甲基异欧前胡内酯; Cnidilin CFN90590 14348-22-2 C17H16O5 = 300.31 10mg QQ客服:3257982914
    氧化前胡素; Oxypeucedanin CFN90350 737-52-0 C16H14O5 = 286.28 20mg QQ客服:215959384
    水合氧化前胡素; Oxypeucedanin hydrate CFN90557 2643-85-8 C16H16O6 = 304.29 20mg QQ客服:2932563308
    佛手柑素; Bergamotine CFN90592 7380-40-7 C21H22O4 = 338.4 10mg QQ客服:2932563308

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