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  • 羌活醇

    Notopterol

    羌活醇
    产品编号 CFN98563
    CAS编号 88206-46-6
    分子式 = 分子量 C21H22O5 = 354.40
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Coumarins
    植物来源 The roots of Notopterygium incisum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    羌活醇 CFN98563 88206-46-6 10mg QQ客服:2932563308
    羌活醇 CFN98563 88206-46-6 20mg QQ客服:2932563308
    羌活醇 CFN98563 88206-46-6 50mg QQ客服:2932563308
    羌活醇 CFN98563 88206-46-6 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • Regional Crop Research Institute (Korea)
  • University of Toronto (Canada)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Kyushu University (Japan)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidade do Porto (Portugal)
  • Hamdard University (India)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Zurich (Switzerland)
  • Universidad de Buenos Aires (Argentina)
  • University of Wuerzburg (Germany)
  • University of Otago (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Chromatogr Sci.2015, 53(5):824-9
  • Nat Prod Sci.2016, 22(2)
  • Universidade Estadual Paulista2017, 11449
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Molecules.2017, 22(11)
  • Journal of Life Science2017, 233-240
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Anal Chim Acta.2018, 1039:162-171
  • Molecules.2018, 23(10):E2638
  • Phytother Res.2018, 32(12):2551-2559
  • Front Pharmacol.2018, 9:756
  • Wageningen University & Research2018, January 2018
  • Nutr Res Pract2019, 13:e45
  • Molecules.2019, 24(16):E3003
  • Molecules.2019, 24(24),4583
  • Cell Chem Biol.2019, 26(1):27-34
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Aquaculture2019, 510:392-399
  • Phytomedicine.2019, 57:95-104
  • Oxid Med Cell Longev2019, 9056845:13
  • Food Analytical Methods2020, 1-10
  • Plant Cell Tiss Org2020, 1-16
  • J Pharmaceut Biomed2020, 178:112894
  • ...
  • 生物活性
    Description: Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities, it shows significant antiproliferative activity against the HepG-2, MCF-7 and C6 cancer cell lines.
    Targets: Immunology & Inflammation related
    In vitro:
    Planta Med. 2010 Jan;76(1):82-5.
    Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines.[Pubmed: 19653148]
    Bioassay-guided fractionation of the antiproliferative chloroform extract of the traditional Chinese medicine Qiang-Huo (Notopterygium incisum) led to the isolation of nine linear furocoumarins (1- 9).
    METHODS AND RESULTS:
    All the isolates were tested against two human cancer cell lines (HepG-2 and MCF-7) and a rat cancer cell line (C6) using the MTT assay method. Among them, notopol (1), notopterol (2), 5-[(2 E,5 Z)-7-hydroxy-3,7-dimethyl-2,5-octadienoxy]psoralene (3), and 5-[(2,5)-epoxy-3-hydroxy-3,7-dimethyl-6-octenoxy]psoralene (4) showed significant antiproliferative activity against the HepG-2 and C6 cancer cell lines, with IC(50) values of 7.7-24.8 microg/mL (5-FU: ca. 5 microg/mL). Compounds 1- 3 also showed moderate cytotoxicity against the MCF-7 cancer cell line, with IC(50) values of 39.4-61.3 microg/mL (5-FU: 17.3 microg/mL). The cell cycle-specific inhibition and apoptosis induced by compounds 1 and 2 were determined using flow cytometry.
    CONCLUSIONS:
    The structure-activity relationship (SAR) is briefly discussed herein. It was found that the presence of a free hydroxy at the lipophilic side chain linked to C-5 of the linear furocoumarins was essential for their in vitro antiproliferative activity.
    In vivo:
    Chem Pharm Bull (Tokyo). 1993 May;41(5):926-9.
    Analgesic component of Notopterygium incisum Ting.[Pubmed: 8339339]

    METHODS AND RESULTS:
    Notopterol was identified as the analgesic component of Notopterygium incisum TING by using the acetic acid-induced writhing method. Notopterol also indicated an anti-inflammatory activity by its inhibitory effect in the vascular permeability test. The intensive prolongation of pentobarbital-induced hypnosis was possibly caused by its inhibitory effect on the drug metabolism in liver. Pharmacological differences between the analgesic components of N. incisum, Aralia cordata and Angelica pubescens were also discussed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
    5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
    10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
    50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    羌活酚; Notoptol CFN95218 88206-49-9 C21H22O5 = 354.4 5mg QQ客服:1148253675
    环氧香柠檬素; Epoxybergamottin CFN70306 206978-14-5 C21H22O5 = 354.4 5mg QQ客服:1148253675
    6',7'-二羟薄荷素; 6',7'-Dihydroxybergamottin CFN98307 264234-05-1 C21H24O6 = 372.4 10mg QQ客服:1413575084
    6',7'-二羟薄荷素缩丙酮; 6',7'-Dihydroxybergamottin acetonide CFN97165 684217-08-1 C24H28O6 = 412.5 5mg QQ客服:1148253675
    6'-羟基-7'-乙氧基香柠檬亭; 6'-Hydroxy-7'-ethoxybergamottin CFN97583 N/A C23H28O6 = 400.5 5mg QQ客服:215959384
    8-氧甲基异欧前胡内酯; Cnidilin CFN90590 14348-22-2 C17H16O5 = 300.31 10mg QQ客服:2159513211
    氧化前胡素; Oxypeucedanin CFN90350 737-52-0 C16H14O5 = 286.28 20mg QQ客服:2159513211
    水合氧化前胡素; Oxypeucedanin hydrate CFN90557 2643-85-8 C16H16O6 = 304.29 20mg QQ客服:3257982914
    佛手柑素; Bergamotine CFN90592 7380-40-7 C21H22O4 = 338.4 10mg QQ客服:1148253675
    羌活醇; Notopterol CFN98563 88206-46-6 C21H22O5 = 354.40 20mg QQ客服:3257982914

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