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    Oxypeucedanin hydrate

    产品编号 CFN90557
    CAS编号 2643-85-8
    分子式 = 分子量 C16H16O6 = 304.29
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica.
    产品名称 产品编号 CAS编号 包装 QQ客服
    水合氧化前胡素 CFN90557 2643-85-8 10mg QQ客服:3257982914
    水合氧化前胡素 CFN90557 2643-85-8 20mg QQ客服:3257982914
    水合氧化前胡素 CFN90557 2643-85-8 50mg QQ客服:3257982914
    水合氧化前胡素 CFN90557 2643-85-8 100mg QQ客服:3257982914
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  • 生物活性
    Description: Oxypeucedanin hydrate is an antimutagenic agent, it has antioxidant activity, and exhibits carbohydrate metabolizing enzymes inhibitory effect.
    Targets: p21 | EGFR | Estrogen receptor | Caspase | Progestogen receptor
    In vitro:
    J Chromatogr B Biomed Sci Appl. 2001 Apr 5;753(2):309-14.
    Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.[Pubmed: 11334345]

    A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main components of hot water extract of Angelica dahurica root (AE), in rat plasma. Plasma sample was simply deproteinated with perchloric acid. After centrifugation, the supernatant was injected into a column-switching HPLC system consisting of a clean-up column (Symmetry Shield RP 8, 20x3.9 mm I.D.) and analytical column (Symmetry C18, 75x4.6 mm I.D.) which were connected with a six-port switching valve. The flow-rate of the mobile phase (acetonitrile-water, 20:80) was maintained at 1 ml/min. Detection was carried out at wavelength 260 nm with a UV detector. The column temperature was maintained at 40 degrees C. The calibration curves of byak-angelicin and oxypeucedanin hydrate were linear over the ranges 19.6 to 980 ng/ml (r2>0.997). The accuracy of these analytes was less than 4.4%. The intra- and inter-day relative standard deviations of byak-angelicin and oxypeucedanin hydrate were within 12.0% and 12.7%, respectively.
    The present method was applied for the analysis of plasma concentration from rats after administration of AE.
    In vivo:
    Biomed Res Int. 2014;2014:480545.
    Preliminary in vitro and in vivo evaluation of antidiabetic activity of Ducrosia anethifolia Boiss. and its linear furanocoumarins.[Pubmed: 24800231]
    Ducrosia anethifolia is used as flavoring additive. There have been little detailed phytochemical reports on this genus and the antidiabetic activity of this plant is not yet evaluated.
    Structure of compounds was deduced by spectroscopic analyses. Preliminary in vitro evaluation of the antidiabetic activity of crude extract and its furanocoumarins was carried out ( α -amylase, α -glucosidase, and β -galactosidase). The in vivo activity was investigated by measuring some oxidative stress markers. Biomarkers of liver injury and kidney were also determined. Eight linear furanocoumarins, psoralen, 5-methoxypsoralen, 8-methoxypsoralen, imperatorin, isooxypeucedanin, pabulenol, oxypeucedanin methanolate, oxypeucedanin hydrate, and 3-O-glucopyranosyl- β -sitosterol, were isolated. All compounds were reported for the first time from the genus Ducrosia except pabulenol. The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. The compounds showed inhibitory activity in a concentration dependant manner. Imperatorin and 5-methoxypsoralen showed the most potent inhibiting power.
    D. anethifolia extract showed hypoglycemic, hypolipidemic, and antioxidant effect as well as ameliorating kidney function. This extract and some linear furanocoumarins exhibited carbohydrate metabolizing enzymes inhibitory effect.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2863 mL 16.4317 mL 32.8634 mL 65.7268 mL 82.1585 mL
    5 mM 0.6573 mL 3.2863 mL 6.5727 mL 13.1454 mL 16.4317 mL
    10 mM 0.3286 mL 1.6432 mL 3.2863 mL 6.5727 mL 8.2158 mL
    50 mM 0.0657 mL 0.3286 mL 0.6573 mL 1.3145 mL 1.6432 mL
    100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6573 mL 0.8216 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6'-羟基-7'-乙氧基香柠檬亭; 6'-Hydroxy-7'-ethoxybergamottin CFN97583 N/A C23H28O6 = 400.5 5mg QQ客服:1413575084
    8-氧甲基异欧前胡内酯; Cnidilin CFN90590 14348-22-2 C17H16O5 = 300.31 10mg QQ客服:2159513211
    氧化前胡素; Oxypeucedanin CFN90350 737-52-0 C16H14O5 = 286.28 20mg QQ客服:1457312923
    水合氧化前胡素; Oxypeucedanin hydrate CFN90557 2643-85-8 C16H16O6 = 304.29 20mg QQ客服:1457312923
    佛手柑素; Bergamotine CFN90592 7380-40-7 C21H22O4 = 338.4 10mg QQ客服:2056216494
    羌活醇; Notopterol CFN98563 88206-46-6 C21H22O5 = 354.40 20mg QQ客服:2932563308
    羌活酚; Notoptol CFN95218 88206-49-9 C21H22O5 = 354.4 5mg QQ客服:1413575084
    环氧香柠檬素; Epoxybergamottin CFN70306 206978-14-5 C21H22O5 = 354.4 5mg QQ客服:1413575084
    6',7'-二羟薄荷素; 6',7'-Dihydroxybergamottin CFN98307 264234-05-1 C21H24O6 = 372.4 10mg QQ客服:2159513211
    6',7'-二羟薄荷素缩丙酮; 6',7'-Dihydroxybergamottin acetonide CFN97165 684217-08-1 C24H28O6 = 412.5 5mg QQ客服:1457312923





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