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    Lucidumol A

    Lucidumol A

    Lucidumol A
    产品编号 CFN95059
    CAS编号 217476-73-8
    分子式 = 分子量 C30H48O4 = 472.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Lucidumol A CFN95059 217476-73-8 1mg QQ客服:3257982914
    Lucidumol A CFN95059 217476-73-8 5mg QQ客服:3257982914
    Lucidumol A CFN95059 217476-73-8 10mg QQ客服:3257982914
    Lucidumol A CFN95059 217476-73-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Siksha O Anusandhan University (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Helmholtz Zentrum München (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Illinois at Chicago (USA)
  • University of Wollongong (Australia)
  • China Medical University (Taiwan)
  • Kyung Hee University (Korea)
  • Kyushu University (Japan)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Monash University Malaysia (Malaysia)
  • Mahatma Gandhi University (India)
  • National Research Council of Canada (Canada)
  • University of Padjajaran (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2014, 9(5):679-82
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Front Immunol.2017, 8:1542
  • Drug Test Anal.2018, 10(10):1579-1589
  • Anal Chim Acta.2018, 1039:162-171
  • Food Res Int.2018, 106:909-919
  • Nat Chem Biol.2018, 14(8):760-763
  • Molecules.2018, 23(2)
  • Biochemistry.2018, 57(40):5886-5896
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Pharmacological Reports2020, 1-9
  • J Nat Med.2020, 74(1):65-75
  • Nutrients.2020, 12(5):1242.
  • Food Res Int.2020, 133:109130.
  • South African J of Botany2020, 135:50-57
  • J of Applied Biological Chem.2020, 63(2):147-152
  • J of Food Quality2020, 8851285.
  • Antioxidants (Basel).2020, 9(11):1121.
  • Research Square2020, doi: 10.21203.
  • Phytochemistry.2021, 181:112539.
  • ...
  • 生物活性
    Description: Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM.
    Targets: HMG-CoA Reductase
    In vitro:
    Phytother Res. 2015 Nov;29(11):1744-52.
    Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells.[Pubmed: 26292672 ]
    The medicinal mushroom Ganoderma lucidum is well recognized for its effective cancer-preventative and therapeutic properties, while specific components responsible for these anticancer effects are not well studied.
    METHODS AND RESULTS:
    Six triterpenoids that are ganolucidic acid E, lucidumol A, ganodermanontriol, 7-oxo-ganoderic acid Z, 15-hydroxy-ganoderic acid S, and ganoderic acid DM were isolated and identified from an extract of the mushroom. All compounds reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 μM. Moreover, the six compounds induced apoptosis in HeLa cells with a maximum increase (22%) of sub-G1 accumulations and 43.03% apoptotic cells in terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay (15-hydroxy-ganoderic acid S treatment). Apoptosis was further confirmed by annexin-V staining. Four of the compounds also caused apoptosis in Caco-2 cells with maximum 9.5% increase of sub-G1 accumulations (7-oxo-ganoderic acid Z treatment) and maximum 29.84% apoptotic cells in TUNEL assay (ganoderic acid DM treatment). Contrarily, none of the compounds induced apoptosis in HepG2 cells.
    CONCLUSIONS:
    The different responses of the three cell lines following these treatments indicated that the bioactive properties of these compounds may vary from cells of different sites of origin and are likely acting under diverse regulatory mechanisms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1155 mL 10.5775 mL 21.1551 mL 42.3101 mL 52.8877 mL
    5 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
    10 mM 0.2116 mL 1.0578 mL 2.1155 mL 4.231 mL 5.2888 mL
    50 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
    100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4231 mL 0.5289 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:2932563308
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:3257982914
    灵芝酮A; Ganoderone A CFN90303 873061-79-1 C30H48O3 = 456.70 5mg QQ客服:2932563308
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:2056216494
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:2932563308
    Lucialdehyde B; Lucialdehyde B CFN90305 480439-84-7 C30H44O3 = 452.67 5mg QQ客服:2159513211
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:2159513211
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:1413575084
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:1457312923
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:2159513211

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