• 中药标准品生产商,产品定制服务
  • Leojaponin

    Leojaponin

    Leojaponin
    产品编号 CFN89087
    CAS编号 864817-63-0
    分子式 = 分子量 C20H26O3 = 314.42
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The aerial parts of Leonurus sibiricus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Leojaponin CFN89087 864817-63-0 1mg QQ客服:215959384
    Leojaponin CFN89087 864817-63-0 5mg QQ客服:215959384
    Leojaponin CFN89087 864817-63-0 10mg QQ客服:215959384
    Leojaponin CFN89087 864817-63-0 20mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida A&M University (USA)
  • Charles University in Prague (Czech Republic)
  • University of Queensland (Australia)
  • Seoul National University (Korea)
  • University of Hertfordshire (United Kingdom)
  • Universidade da Beira Interior (Germany)
  • Copenhagen University (Denmark)
  • Almansora University (Egypt)
  • National Chung Hsing University (Taiwan)
  • University of Illinois at Chicago (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • National Hellenic Research Foundation (Greece)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Anna University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Med.2015, 35(5):1237-45
  • Oncotarget.2015, 6(31):30831-49
  • Br J Pharmacol.2016, 173(2):396-410
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Chemistry of Plant Materials.2016, 33-46
  • Int J Mol Med.2016, 37(2):501-8
  • Srinagarind Medical Journal2017, 32(1)
  • Front Immunol.2017, 8:1542
  • Nutrients.2018, 10(12):E1998
  • Anal Chim Acta.2018, 1039:162-171
  • Int J Biol Macromol.2018, 112:1093-1103
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Life Sci.2018, 209:498-506
  • Mol Cells.2018, 41(8):771-780
  • Korean J Dent Mater.2018, 45(2):139-146
  • Front Pharmacol.2018, 9:756
  • J Mol Med (Berl).2018, 96(7):661-672
  • Int J Mol Sci.2019, 20(14):E3538
  • Saudi Pharm J.2019, 27(1):145-153
  • Phytomedicine.2019, 61:152813
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Food Sci Nutr.2019, 8(1):246-256
  • LWT-Food Sci Technol2020, 109163
  • ...
  • 生物活性
    Description: Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm.
    Targets: AChR | POP
    In vitro:
    Nat Prod Res. 2017 Jun;31(12):1459-1463.
    Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil.[Pubmed: 27834099 ]

    METHODS AND RESULTS:
    Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid Leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors.
    CONCLUSIONS:
    Extracts obtained by maceration were active against POP (53-58%), but showed weak activity against AChE. The isolated Leojaponin and leonurine were evaluated as POP inhibitors.
    Phytother Res. 2010 Aug;24(8):1256-9.
    Three diterpenes from Leonurus japonicus Houtt protect primary cultured rat cortical cells from glutamate-induced toxicity.[Pubmed: 20658574]
    To examine the cytoprotective effects of Leonurus japonicus Houtt, its protection against the glutamate-induced toxicity in primary cortical cultured neurons was tested.
    METHODS AND RESULTS:
    In order to clarify the cytoprotective mechanism(s) of this observed effect, isolation was performed to seek and identify active fractions and components. By such fractionation, three known diterpenes--prehispanolone (1), Leojaponin (2) and iso-preleoheterin (3)--were isolated from the methanol extracts from the air-dried L. japonicus. Among these three compounds, Leojaponin (2) exhibited significant cytoprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50%, at concentrations ranging from 0.1 microm to 10 microm.
    CONCLUSIONS:
    Therefore, the cytoprotective effect of L. japonicus might be due to the inhibition of glutamate-induced toxicity by the diterpenes it contains.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1805 mL 15.9023 mL 31.8046 mL 63.6092 mL 79.5115 mL
    5 mM 0.6361 mL 3.1805 mL 6.3609 mL 12.7218 mL 15.9023 mL
    10 mM 0.318 mL 1.5902 mL 3.1805 mL 6.3609 mL 7.9511 mL
    50 mM 0.0636 mL 0.318 mL 0.6361 mL 1.2722 mL 1.5902 mL
    100 mM 0.0318 mL 0.159 mL 0.318 mL 0.6361 mL 0.7951 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    15,16-环氧基-12S-羟基赖百当-8(17),13(16),14-三烯; 15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene CFN98075 216011-55-1 C20H30O2 = 302.5 5mg QQ客服:215959384
    狗牙花碱E; Coronarin E CFN99275 117591-81-8 C20H28O = 284.4 5mg QQ客服:2932563308
    姜花素A; 狗牙花碱A; Coronarin A CFN99301 119188-33-9 C20H28O2 = 300.4 5mg QQ客服:3257982914
    滇姜花素A; Yunnancoronarin A CFN99689 162762-93-8 C20H28O2 = 300.4 5mg QQ客服:3257982914
    果药烯酮; Hedychenone CFN98942 56324-54-0 C20H26O2 = 298.4 5mg QQ客服:2159513211
    11,12-二氢-7-羟基草果药烯酮; 11,12-Dihydro-7-hydroxyhedychenone CFN89088 60149-07-7 C20H28O3 = 316.44 5mg QQ客服:1413575084
    Isoleojaponin; Isoleojaponin CFN89151 1840966-49-5 C20H26O3 = 314.42 5mg QQ客服:1413575084
    8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione; 8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione CFN89116 76475-32-6 C22H32O5 = 376.49 5mg QQ客服:2932563308
    6-Dehydroxy-8-hydroxygaleopsinolone; 6-Dehydroxy-8-hydroxygaleopsinolone CFN89108 87440-66-2 C20H28O3 = 316.44 5mg QQ客服:3257982914
    Persianone; Persianone CFN89065 170894-20-9 C40H56O6 = 632.88 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产