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  • 滇姜花素A

    Yunnancoronarin A

    滇姜花素A
    产品编号 CFN99689
    CAS编号 162762-93-8
    分子式 = 分子量 C20H28O2 = 300.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Hedychium yunnanense
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    滇姜花素A CFN99689 162762-93-8 1mg QQ客服:215959384
    滇姜花素A CFN99689 162762-93-8 5mg QQ客服:215959384
    滇姜花素A CFN99689 162762-93-8 10mg QQ客服:215959384
    滇姜花素A CFN99689 162762-93-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland (USA)
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  • Amity University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • Int J Mol Med.2015, 35(5):1237-45
  • Inflammation.2015, 38(4):1502-16
  • Chem Biol Interact.2016, 258:59-68
  • Acta Physiologiae Plantarum2016, 38:7
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Invest New Drugs.2017, 35(2):166-179
  • Microchemical Journal2018, 137:168-173
  • Food Quality and Safety2018, 2:213-219
  • Molecules.2018, 23(2)
  • Toxicol In Vitro.2018, 52:94-105
  • Pathogens.2018, 7(3):E62
  • Nat Commun.2019, 10(1):5169
  • J Cancer.2019, 10(23):5843-5851
  • Drug Invention Today2019, 12(6):1303-1306
  • J Pharm Biomed Anal.2019, 164:119-127
  • J of Essential Oil Research2019, 1677272
  • Int J Mol Sci.2019, 20(9):E2244
  • J Ethnopharmacol.2019, 235:406-414
  • Aquaculture2019, 510:392-399
  • J Funct Foods2019, 54:449-456
  • ...
  • 生物活性
    Description: Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.
    In vitro:
    Phytother Res. 2010 Jul;24(7):1009-13.
    Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells.[Pubmed: 19960422]

    METHODS AND RESULTS:
    Seven labdane-type diterpenes, coronarin E, coronarin A, Yunnancoronarin A, yunnancoronarin B, hedyforrestin B, villosin, and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI-H187) and non-cancerous Vero cells. The results showed that villosin exhibited potent cytotoxic activity with IC(50) of 0.40 microM, which was higher than that of the drug ellipticine (IC(50) 1.79 microM). Moreover, ellipticine was very toxic to Vero cells (IC(50) 7.47 microM) whereas the toxicity of villosin was undetectable at concentration lower than 166.42 microM.
    CONCLUSIONS:
    The results have indicated that the lactone ring is essential for high cytotoxic activity and that the presence of a hydroxyl group at the 6 or 7 position causes decrease in activity. The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3289 mL 16.6445 mL 33.2889 mL 66.5779 mL 83.2224 mL
    5 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
    10 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
    50 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
    100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Leojaponin; Leojaponin CFN89087 864817-63-0 C20H26O3 = 314.42 5mg QQ客服:1413575084
    15,16-环氧-12R-羟基赖百当-8(17),13(16),14-三烯; 15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene CFN97053 61597-55-5 C20H30O2 = 302.5 5mg QQ客服:1413575084
    15,16-环氧基-12S-羟基赖百当-8(17),13(16),14-三烯; 15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene CFN98075 216011-55-1 C20H30O2 = 302.5 5mg QQ客服:3257982914
    狗牙花碱E; Coronarin E CFN99275 117591-81-8 C20H28O = 284.4 5mg QQ客服:3257982914
    姜花素A; 狗牙花碱A; Coronarin A CFN99301 119188-33-9 C20H28O2 = 300.4 5mg QQ客服:215959384
    滇姜花素A; Yunnancoronarin A CFN99689 162762-93-8 C20H28O2 = 300.4 5mg QQ客服:1413575084
    果药烯酮; Hedychenone CFN98942 56324-54-0 C20H26O2 = 298.4 5mg QQ客服:215959384
    11,12-二氢-7-羟基草果药烯酮; 11,12-Dihydro-7-hydroxyhedychenone CFN89088 60149-07-7 C20H28O3 = 316.44 5mg QQ客服:3257982914
    Isoleojaponin; Isoleojaponin CFN89151 1840966-49-5 C20H26O3 = 314.42 5mg QQ客服:1148253675
    8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione; 8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione CFN89116 76475-32-6 C22H32O5 = 376.49 5mg QQ客服:1148253675

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