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  • 姜花素A; 狗牙花碱A

    Coronarin A

    姜花素A; 狗牙花碱A
    产品编号 CFN99301
    CAS编号 119188-33-9
    分子式 = 分子量 C20H28O2 = 300.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The rhizomes of Hedychium coronarium
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    姜花素A; 狗牙花碱A CFN99301 119188-33-9 1mg QQ客服:2159513211
    姜花素A; 狗牙花碱A CFN99301 119188-33-9 5mg QQ客服:2159513211
    姜花素A; 狗牙花碱A CFN99301 119188-33-9 10mg QQ客服:2159513211
    姜花素A; 狗牙花碱A CFN99301 119188-33-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • Exp Parasitol.2015, 153:160-4
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Acta Biochim Pol.2015, 62(2):253-8
  • Int J Oncol.2016, 49(4):1497-504
  • Nat Prod Commun.2017, 12(5):771-778
  • Pharm Biol.2017, 55(1):360-366
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  • Neuropharmacology.2018, 131:68-82
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Food Chem.2018, 262:78-85
  • Sci Rep.2018, 8:9267
  • Planta Med.2018, 84(15):1101-1109
  • Food Res Int.2019, 123:125-134
  • Industrial Crops and Products2019, 140:111612
  • Plant Physiol Biochem.2019, 144:355-364
  • Molecules.2019, 24(19):E3417
  • Journal of Apiculture2019, 34(2):131-136
  • Phytomedicine.2019, 56:48-56
  • Genes Genomics.2020, 10.1007
  • Biosci. Rep.2020, 10.1024
  • Food Funct.2020, 10.1039
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the growth factor induced tube formation of HUVEC at the concentration of 10 microg/mL. Coronarin A has anti-inflammatory activity, it exhibits potent inhibition (IC50 <6.1708g/mL) against fMLP-induced superoxide production and elastase release.
    Targets: Immunology & Inflammation related
    In vitro:
    Chem Pharm Bull (Tokyo). 2012;60(2):246-50.
    Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.[Pubmed: 22293485]
    The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine.
    METHODS AND RESULTS:
    From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), Coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
    CONCLUSIONS:
    Among of them, compounds 1-3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 μM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC(50) values of 46.0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.
    Phytother Res. 2010 Jul;24(7):1009-13. doi: 10.1002/ptr.3057.
    Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells.[Pubmed: 19960422]

    METHODS AND RESULTS:
    Seven labdane-type diterpenes, coronarin E, Coronarin A, yunnanCoronarin A, yunnancoronarin B, hedyforrestin B, villosin, and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI-H187) and non-cancerous Vero cells. The results showed that villosin exhibited potent cytotoxic activity with IC(50) of 0.40 microM, which was higher than that of the drug ellipticine (IC(50) 1.79 microM). Moreover, ellipticine was very toxic to Vero cells (IC(50) 7.47 microM) whereas the toxicity of villosin was undetectable at concentration lower than 166.42 microM.
    CONCLUSIONS:
    The results have indicated that the lactone ring is essential for high cytotoxic activity and that the presence of a hydroxyl group at the 6 or 7 position causes decrease in activity. The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development.
    Planta Med., 2011, 77(12):1344-1344.
    New labdane-type diterpenoids and anti-inflammatory constituents from the rhizome of Hedychium coronarium[Reference: WebLink]

    METHODS AND RESULTS:
    Hedychium coronarium J.Koenig (Zingiberaceae) is a terrestrial epiphytic herb, which is distribution in India, Malaysia, Vietnam, southern China and Taiwan [1]. Two new labdane-type diterpenoids, hedychicoronarin (1) and peroxycoronarin D (2), together with eleven known compounds, including calcaratarin (3), (+)-Coronarin A (4), coronarin D (5), coronarin D methyl ether (6), (E)-labda-8(17),12-diene-15,16-dial (7), ergosta-4,6,8(14),22-tetraen-3-one (8), β-sitostenone (9), stigmasta-4,22-dien-3-one (10), oleic acid (11), stearic acid (12), and palmitic acid (13) have been isolated from the rhizomes of Hedychium coronarium. The structure of new compounds 1 and 2 was determined through spectral analyses including extensive 2D NMR data.
    CONCLUSIONS:
    Among the isolates, calcaratarin (3), Coronarin A (4), (E)-labda-8(17),12-diene-15,16-dial (7), and oleic acid (11) exhibited potent inhibition (IC50 <6.17μg/mL) against fMLP-induced superoxide production and elastase release.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3289 mL 16.6445 mL 33.2889 mL 66.5779 mL 83.2224 mL
    5 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
    10 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
    50 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
    100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    狗牙花碱E; Coronarin E CFN99275 117591-81-8 C20H28O = 284.4 5mg QQ客服:2159513211
    姜花素A; 狗牙花碱A; Coronarin A CFN99301 119188-33-9 C20H28O2 = 300.4 5mg QQ客服:2159513211
    滇姜花素A; Yunnancoronarin A CFN99689 162762-93-8 C20H28O2 = 300.4 5mg QQ客服:3257982914
    果药烯酮; Hedychenone CFN98942 56324-54-0 C20H26O2 = 298.4 5mg QQ客服:1148253675
    11,12-二氢-7-羟基草果药烯酮; 11,12-Dihydro-7-hydroxyhedychenone CFN89088 60149-07-7 C20H28O3 = 316.44 5mg QQ客服:1413575084
    Isoleojaponin; Isoleojaponin CFN89151 1840966-49-5 C20H26O3 = 314.42 5mg QQ客服:2159513211
    8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione; 8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione CFN89116 76475-32-6 C22H32O5 = 376.49 5mg QQ客服:2932563308
    6-Dehydroxy-8-hydroxygaleopsinolone; 6-Dehydroxy-8-hydroxygaleopsinolone CFN89108 87440-66-2 C20H28O3 = 316.44 5mg QQ客服:1413575084
    Persianone; Persianone CFN89065 170894-20-9 C40H56O6 = 632.88 5mg QQ客服:2159513211
    Hispanone; Hispanone CFN89110 82462-67-7 C20H28O2 = 300.44 5mg QQ客服:2932563308

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