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  • 异绿原酸A

    Isochlorogenic acid A

    异绿原酸A
    产品编号 CFN99118
    CAS编号 2450-53-5
    分子式 = 分子量 C25H24O12 = 516.45
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The flowerbuds of Lonicera japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异绿原酸A CFN99118 2450-53-5 10mg QQ客服:3257982914
    异绿原酸A CFN99118 2450-53-5 20mg QQ客服:3257982914
    异绿原酸A CFN99118 2450-53-5 50mg QQ客服:3257982914
    异绿原酸A CFN99118 2450-53-5 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Queensland (Australia)
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  • University of Malaya (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Korea Society of Pha.2014, 300-314
  • Sci. Rep.2015, 14-23
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • FEBS Lett.2015, 589(1):182-7
  • Nat Prod Sci.2016, 22(2)
  • J Pharm Anal.2016, 6(6):363-373
  • J Agric Food Chem.2016, 64(35):6783-90
  • BMC Complement Altern Med.2017, 17(1):393
  • J Food Compos Anal2017, 62:197-204
  • J Nat Prod.2017, 80(4):854-863
  • Analytical Methods2018, 10(27)
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • J Nat Prod.2018, 81(4):966-975
  • Front Pharmacol.2018, 9:236
  • Front Pharmacol.2019, 10:1226
  • Plant Physiol Biochem.2019, 144:355-364
  • Food Chem.2019, 279:80-87
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • J Funct Foods2019, 54:449-456
  • J Clin Med.2019, 8(10):E1664
  • Oxid Med Cell Longev2020, 12
  • ...
  • 生物活性
    Description: Isochlorogenic acid A has antiviral, antioxidant, hepatoprotective and potent anti-hepatitis B activities.
    Targets: HBV | HO-1
    In vitro:
    J Ethnopharmacol. 2012 Oct 31;144(1):190-4.
    Hepatoprotective and antiviral properties of isochlorogenic acid A from Laggera alata against hepatitis B virus infection.[Pubmed: 22982394]
    The aim of this study was to determine the anti-hepatitis B effect of isochlorogenic acid A isolated from Laggera alata (Asteraceae), a traditional Chinese herbal medicine.
    METHODS AND RESULTS:
    The anti-hepatitis B activity of isochlorogenic acid A was evaluated by the D-galactosamine (D-GalN)-induced HL-7702 hepatocyte damage model and the HBV-transfected HepG2.2.15 cells. Isochlorogenic acid A significantly improved HL-7702 hepatocyte viability and markedly inhibited the productions of HBsAg and HBeAg. The inhibitory rates of isochlorogenic acid A on the HBsAg and HBeAg expressions were 86.9% and 72.9%, respectively. In addition, isochlorogenic acid A declined markedly the content of hepatitis B virus covalently closed circular DNA (HBV cccDNA) and induced significantly the heme oxygenase-1 (HO-1) expression in HepG2.2.15 cells.
    CONCLUSIONS:
    Isochlorogenic acid A was verified to possess the potent anti-hepatitis B activity. The anti-HBV target of isochlorogenic acid A is probably associated with blocking the translation step of the HBV replication. Overexpression of HO-1 may contribute to the anti-HBV activity of isochlorogenic acid A by reducing the stability of the HBV core protein and thus blocking the refill of nuclear HBV cccDNA. Additionally, the hepatoprotective effect of isochlorogenic acid A could be achieved by its antioxidative property and induction of HO-1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9363 mL 9.6815 mL 19.363 mL 38.7259 mL 48.4074 mL
    5 mM 0.3873 mL 1.9363 mL 3.8726 mL 7.7452 mL 9.6815 mL
    10 mM 0.1936 mL 0.9681 mL 1.9363 mL 3.8726 mL 4.8407 mL
    50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7745 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3873 mL 0.4841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:2932563308
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:3257982914
    3,5-O-二咖啡酰基奎宁酸甲酯; 3,5-Di-O-caffeoylquinic acid methyl ester CFN90857 159934-13-1 C26H26O12 = 530.5 5mg QQ客服:2159513211
    异绿原酸C; Isochlorogenic acid C CFN99120 32451-88-0 C25H24O12 = 516.45 20mg QQ客服:215959384
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:1413575084
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:2932563308
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 10mg QQ客服:2159513211
    菊苣酸; Chicoric acid CFN99725 70831-56-0 C22H18O12 = 474.37 20mg QQ客服:215959384
    1,5-二咖啡酰奎宁酸; 洋蓟素; 1,5-Dicaffeoylquinic acid CFN99123 30964-13-7 C25H24O12 = 516.45 20mg QQ客服:1413575084
    异绿原酸B; Isochlorogenic acid B CFN99119 14534-61-3 C25H24O12 = 516.45 20mg QQ客服:1148253675

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