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  • 3,5-O-二咖啡酰基奎宁酸甲酯

    3,5-Di-O-caffeoylquinic acid methyl ester

    3,5-O-二咖啡酰基奎宁酸甲酯
    产品编号 CFN90857
    CAS编号 159934-13-1
    分子式 = 分子量 C26H26O12 = 530.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The flowerbud of Lonicera japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,5-O-二咖啡酰基奎宁酸甲酯 CFN90857 159934-13-1 1mg QQ客服:1148253675
    3,5-O-二咖啡酰基奎宁酸甲酯 CFN90857 159934-13-1 5mg QQ客服:1148253675
    3,5-O-二咖啡酰基奎宁酸甲酯 CFN90857 159934-13-1 10mg QQ客服:1148253675
    3,5-O-二咖啡酰基奎宁酸甲酯 CFN90857 159934-13-1 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Universiti Malaysia Pahang (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(12):9385-93
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Molecules.2016, 21(6)
  • Nutrients.2017, 10(1)
  • Biochem Systematics and Ecology2017, 11-18
  • Molecules.2017, 22(12)
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • J Food Compos Anal2017, 62:197-204
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • BMC Plant Biol.2018, 18(1):122
  • Molecules.2018, 23(12):E3103
  • Anat Rec2018, 24264
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • J Nat Med.2018, 72(3):734-744
  • Journal of Ginseng Research2019, 10.1016
  • Biomed Pharmacother.2019, 111:262-269
  • Neuropharmacology2019, 151437
  • Pak J Pharm Sci.2019, 32(6)
  • Phytomedicine.2019, 62:152962
  • Planta Med.2019, 85(4):347-355
  • Oxid Med Cell Longev2020, 12
  • ...
  • 生物活性
    Description: 3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. 3,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.
    Targets: HSV
    In vitro:
    Chinese Traditional & Herbal Drugs, 2015 , 46 (11) :1597-602.
    Study on chemical constituents from Re-Du-Ning Injection(Ⅱ)[Reference: WebLink]
    To investigate the chemical constituents from Re-Du-Ning Injection(RDN).
    METHODS AND RESULTS:
    The chemical constituents were isolated by chromatography on silica gel, ODS, Sephadex LH-20, and Toyopearl HW-40 columns and reverse phase MPLC and HPLC repeatedly. Their structures were identified by spectral data and physicochemical property. Sixteen compounds were isolated and identified as 5-O-caffeoylquinic acid(1), 5-O-caffeoylquinic acid methyl ester(2), 4-O-caffeoylquinic acid(3), 5-O-caffeoylquinic acid methyl ester(4), 4,5-di-O-caffeoylquinic acid(5), 4,5-di-O-caffeoylquinic acid methyl ester(6), 3,5-di-O-caffeoylquinic acid(7), 3,5-Di-O-caffeoylquinic acid methyl ester(8), 3,4-di-O-caffeoylquinic acid(9), 3,4-di-O-caffeoylquinic acid methyl ester(10), secologanic acid(11), vogeloside(12), 7-epi-vogeloside(13), E-aldosecologanin(14), Z-aldosecologanin(15), and 5H,8H-pyrano [4,3-d] thiazolo [3,2-a] pyridine-3-carboxylic acid(16). Compounds 1—10 showed high efficiency and low toxicity with antivirus activity against RSV.
    CONCLUSIONS:
    All the isolated compounds are reported from RDN Injection for the first time, and caffeoylquinic acids may be one of antivirus pharmacodynamic material bases of RDN.
    Arch Pharm Res. 2008 Jul;31(7):900-4.
    Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase.[Pubmed: 18704333 ]

    METHODS AND RESULTS:
    Seven phenolic compounds, caffeic acid (1), 4-hydroxybenzoic acid (2), 4-methoxybenzoic acid (3), protocatechuic acid (4), eugenol O-beta-D: -glucopyranoside (5), 3,6-di-O-feruloylsucrose (6), and 3,5-di-O-caffeoylquinic acid methyl ester (7), were isolated from an EtOAc-soluble partition of the flowers of Erigeron annuus. The structures of 1-7 were determined by spectroscopic data interpretation, particularly 1D and 2D NMR studies, and by comparison of their data with those published in the literature. All the isolates were subjected to in vitro bioassays to evaluate their inhibitory activities against the formation of advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR).
    CONCLUSIONS:
    Of the compounds, 1, 6, and 7 exhibited potent inhibitory activities against the formation of AGEs. In the RLAR assay, compound 7 showed the most potent inhibitory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.885 mL 9.4251 mL 18.8501 mL 37.7003 mL 47.1254 mL
    5 mM 0.377 mL 1.885 mL 3.77 mL 7.5401 mL 9.4251 mL
    10 mM 0.1885 mL 0.9425 mL 1.885 mL 3.77 mL 4.7125 mL
    50 mM 0.0377 mL 0.1885 mL 0.377 mL 0.754 mL 0.9425 mL
    100 mM 0.0189 mL 0.0943 mL 0.1885 mL 0.377 mL 0.4713 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:3257982914
    3,5-O-二咖啡酰基奎宁酸甲酯; 3,5-Di-O-caffeoylquinic acid methyl ester CFN90857 159934-13-1 C26H26O12 = 530.5 5mg QQ客服:1148253675
    异绿原酸C; Isochlorogenic acid C CFN99120 32451-88-0 C25H24O12 = 516.45 20mg QQ客服:215959384
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:2159513211
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:1413575084
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 10mg QQ客服:1413575084
    菊苣酸; Chicoric acid CFN99725 70831-56-0 C22H18O12 = 474.37 20mg QQ客服:215959384
    1,5-二咖啡酰奎宁酸; 洋蓟素; 1,5-Dicaffeoylquinic acid CFN99123 30964-13-7 C25H24O12 = 516.45 20mg QQ客服:2932563308
    异绿原酸B; Isochlorogenic acid B CFN99119 14534-61-3 C25H24O12 = 516.45 20mg QQ客服:215959384
    3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate CFN91970 143051-73-4 C27H28O12 = 544.50 5mg QQ客服:2159513211

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