• 中药标准品生产商,产品定制服务
  • 菊苣酸

    Chicoric acid

    菊苣酸
    产品编号 CFN99725
    CAS编号 70831-56-0
    分子式 = 分子量 C22H18O12 = 474.37
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Echinacea purpurea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    菊苣酸 CFN99725 70831-56-0 10mg QQ客服:3257982914
    菊苣酸 CFN99725 70831-56-0 20mg QQ客服:3257982914
    菊苣酸 CFN99725 70831-56-0 50mg QQ客服:3257982914
    菊苣酸 CFN99725 70831-56-0 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sant Gadge Baba Amravati University (India)
  • Nanjing University of Chinese Medicine (China)
  • Indian Institute of Science (India)
  • Copenhagen University (Denmark)
  • Tokyo Woman's Christian University (Japan)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Wollongong (Australia)
  • National Cancer Center Research Institute (Japan)
  • University of Maryland (USA)
  • University of the Basque Country (Spain)
  • Wroclaw Medical University (Poland)
  • Charles University in Prague (Czech Republic)
  • University of Toronto (Canada)
  • Universidad de Antioquia (Colombia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Biochim Pol.2015, 62(2):253-8
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Pharm Biol.2017, 55(1):360-366
  • J Food Compos Anal2017, 62:197-204
  • Sci Rep.2017, 7:467-479
  • Neuropharmacology.2018, 131:68-82
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • J Ethnopharmacol.2018, 210:88-94
  • Molecules.2018, 23(3):E615
  • Phytomedicine.2018, 40:37-47
  • J Sep Sci.2018, 41(11):2488-2497
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Saf Health Work.2019, 10(2):196-204
  • Food Res Int.2019, 123:125-134
  • Phytother Res.2019, 33(7):1784-1793
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Psychopharmacology (Berl).2020, 10.1007
  • Saudi Pharm J2020, 10.1016
  • United States Patent Application2020, 20200038363
  • ...
  • 生物活性
    Description: Chicoric acid, a new compound able to enhance insulin release and glucose uptake, it is a new potential antidiabetic agent carrying both insulin sensitizing and insulin-secreting properties. Chicoric acid has antiobesity effects, it can induce apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. L-Chicoric acid has antiviral activity against HIV-1, which has been attributed to the inhibition of HIV-1 integration.
    Targets: TLR | NOS | PARP | MMP(e.g.TIMP) | Bcl-2/Bax | Caspase | p38MAPK | JNK | ERK | HO-1 | COX | Akt | PI3K | HIV | NO | PGE | NF-kB | TNF-α
    In vitro:
    J Agric Food Chem. 2013 Feb 20;61(7):1509-20.
    Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways.[Pubmed: 23363008]
    Chicoric acid has been reported to possess various bioactivities. However, the antiobesity effects of chicoric acid remain poorly understood.
    METHODS AND RESULTS:
    In this study, we investigated the effects of chicoric acid on 3T3-L1 preadipocytes and its molecular mechanisms of apoptosis. Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage. Mitochondrial membrane potential (MMP) loss, Bax/Bcl-2 dysregulation, cytochrome c release, and caspase-3 activation were observed, indicating mitochondria-dependent apoptosis induced by chicoric acid. Furthermore, PI3K/Akt and MAPK (p38 MAPK, JNK, and ERK1/2) signaling pathways were involved in chicoric acid-induced apoptosis. The employment of protein kinase inhibitors LY294002, SB203580, SP600125, and U0126 revealed that PI3K/Akt signaling pathway interplayed with MAPK signaling pathways. Moreover, chicoric acid induced reactive oxygen species (ROS) generation.
    CONCLUSIONS:
    Pretreatment with the antioxidant N-acetylcysteine (NAC) significantly blocked cell death and changes of Akt and MAPK signalings induced by chicoric acid. In addition, chicoric acid down regulated HO-1 and COX-2 via the PI3K/Akt pathway.
    Biochem Biophys Res Commun. 2008 Dec 5;377(1):131-5.
    Chicoric acid, a new compound able to enhance insulin release and glucose uptake.[Pubmed: 18834859 ]
    Caffeic acid and chlorogenic acid (CGA), a mono-caffeoyl ester, have been described as potential antidiabetic agents.
    METHODS AND RESULTS:
    Using in vitro studies, we report the effects of a dicaffeoyl ester, chicoric acid (CRA) purified from Cichorium intybus, on glucose uptake and insulin secretion. Our results show that CRA and CGA increased glucose uptake in L6 muscular cells, an effect only observed in the presence of stimulating concentrations of insulin. Moreover, we found that both CRA and CGA were able to stimulate insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans. In the later case, the effect of CRA is only observed in the presence of subnormal glucose levels. Patch clamps studies show that the mechanism of CRA and CGA was different from that of sulfonylureas, as they did not close K(ATP) channels.
    CONCLUSIONS:
    Chicoric acid is a new potential antidiabetic agent carrying both insulin sensitizing and insulin-secreting properties.
    In vivo:
    Fitoterapia. 2014 Mar;93:132-41.
    Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study.[Pubmed: 24418658]
    Ocimum gratissimum L. is popularly used to treat diabetes mellitus. The hypoglycemic activity of this medicinal species has been confirmed by in vivo studies.
    METHODS AND RESULTS:
    The present study conducted a chemical investigation of a leaf decoction (10% p/v) of O. gratissimum monitored by in vivo hypoglycemic activity assays. Four phenolic substances were identified: L-caftaric acid (1), L-Chicoric acid (2), eugenyl-β-D-glucopyranoside (3) and vicenin-2 (4). The acute hypoglycemic activity of the O. gratissimum decoction fractions Og1-S (300 mg/kg), Og1-A (240 mg/kg) and Og1-B (80 mg/kg) was evaluated intraperitoneally in normal and streptozotocin-induced diabetic mice. They reduced glycemia by 63%, 76% and 60% (in 120 min), respectively, in the diabetic mice. Subfractions of Og1-A were also evaluated under the same conditions: Og1-AS (200 mg/kg) and Og1-AP (40 mg/kg) produced a decrease of only 37% and 39%, respectively. Among the major phenolic substances, only Chicoric acid (2; 3 mg/kg) reduced significantly the glycemic levels of diabetic mice by 53%, 120 min after treatment. This is the first study describing the hypoglycemic activity of Chicoric acid in an animal model of diabetes mellitus. In addition, we suggest that there may be other substances contributing to this activity.
    CONCLUSIONS:
    Thus, for the first time, a correlation is established between the hypoglycemic activity of O. gratissimum and its chemical composition.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1081 mL 10.5403 mL 21.0806 mL 42.1612 mL 52.7015 mL
    5 mM 0.4216 mL 2.1081 mL 4.2161 mL 8.4322 mL 10.5403 mL
    10 mM 0.2108 mL 1.054 mL 2.1081 mL 4.2161 mL 5.2701 mL
    50 mM 0.0422 mL 0.2108 mL 0.4216 mL 0.8432 mL 1.054 mL
    100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.4216 mL 0.527 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异绿原酸B; Isochlorogenic acid B CFN99119 14534-61-3 C25H24O12 = 516.45 20mg QQ客服:1413575084
    3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate CFN91970 143051-73-4 C27H28O12 = 544.50 5mg QQ客服:2932563308
    3,4-O-二咖啡酰基奎宁酸甲酯; 3,4-Di-O-caffeoylquinic acid methyl ester CFN90856 114637-83-1 C26H26O12 = 530.5 5mg QQ客服:1413575084
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:3257982914
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:1148253675
    3,5-O-二咖啡酰基奎宁酸甲酯; 3,5-Di-O-caffeoylquinic acid methyl ester CFN90857 159934-13-1 C26H26O12 = 530.5 5mg QQ客服:215959384
    异绿原酸C; Isochlorogenic acid C CFN99120 32451-88-0 C25H24O12 = 516.45 20mg QQ客服:3257982914
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:2932563308
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:215959384
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 10mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产