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  • 4,5-O-二咖啡酰基奎宁酸甲酯

    4,5-Di-O-caffeoylquinic acid methyl ester

    4,5-O-二咖啡酰基奎宁酸甲酯
    产品编号 CFN90858
    CAS编号 188742-80-5
    分子式 = 分子量 C26H26O12 = 530.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The flowerbud of Lonicera japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,5-O-二咖啡酰基奎宁酸甲酯 CFN90858 188742-80-5 1mg QQ客服:1148253675
    4,5-O-二咖啡酰基奎宁酸甲酯 CFN90858 188742-80-5 5mg QQ客服:1148253675
    4,5-O-二咖啡酰基奎宁酸甲酯 CFN90858 188742-80-5 10mg QQ客服:1148253675
    4,5-O-二咖啡酰基奎宁酸甲酯 CFN90858 188742-80-5 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • National Hellenic Research Foundation (Greece)
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  • National Cancer Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J-STAGE2015, 249-255
  • J Ethnopharmacol.2016, 192:370-381
  • Anal Bioanal Chem. 2016, 408(15)
  • Free Radic Biol Med.2016, 97:307-319
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Sci Rep.2017, 7:467-479
  • Nat Prod Commun.2018, 10.1177
  • Int J Mol Sci.2018, 19(2)
  • European Journal of Integrative Medicine2018, 20:165-172
  • Nat Prod Sci.2018, 24(3):206
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • J Nat Prod.2018, 81(4):966-975
  • Front Microbiol.2019, 10:2806
  • Chemistry of Plant Materials.2019, 215-222
  • Food Chem.2019, 279:80-87
  • Food Chem.2019, 290:286-294
  • Phytother Res.2019, 33(7):1784-1793
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Appl Biol Chem2019, 62:46
  • Plos One.2019, 15(2):e0220084
  • Food Analytical Methods2020, 1-10
  • ...
  • 生物活性
    Description: 4,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.
    Targets: HSV
    In vitro:
    Chinese Traditional & Herbal Drugs, 2015 , 46 (11) :1597-602.
    Study on chemical constituents from Re-Du-Ning Injection (II).[Reference: WebLink]
    To investigate the chemical constituents from Re-Du-Ning Injection (RDN).
    METHODS AND RESULTS:
    The chemical constituents were isolated by chromatography on silica gel, ODS, Sephadex LH-20, and Toyopearl HW-40 columns and reverse phase MPLC and HPLC repeatedly. Their structures were identified by spectral data and physicochemical property. Sixteen compounds were isolated and identified as 5-O-caffeoylquinic acid (1), 5-O-caffeoylquinic acid methyl ester (2), 4-O-caffeoylquinic acid (3), 5-O-caffeoylquinic acid methyl ester (4), 4,5-di-O-caffeoylquinic acid (5), 4,5-Di-O-caffeoylquinic acid methyl ester (6), 3,5- di-O-caffeoylquinic acid (7), 3,5-di-O-caffeoylquinic acid methyl ester (8), 3,4-di-O-caffeoylquinic acid (9), 3,4-di-O-caffeoylquinic acid methyl ester (10), secologanic acid (11), vogeloside (12), 7-epi-vogeloside (13), E-aldosecologanin (14), Z-aldosecologanin (15), and 5H,8H-pyrano[4,3-d] thiazolo[3,2-a] pyridine-3-carboxylic acid (16). Compounds 1-10 showed high efficiency and low toxicity with antivirus activity against RSV.
    CONCLUSIONS:
    All the isolated compounds are reported from RDN Injection for the first time, and caffeoylquinic acids may be one of antivirus pharmacodynamic material bases of RDN.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.885 mL 9.4251 mL 18.8501 mL 37.7003 mL 47.1254 mL
    5 mM 0.377 mL 1.885 mL 3.77 mL 7.5401 mL 9.4251 mL
    10 mM 0.1885 mL 0.9425 mL 1.885 mL 3.77 mL 4.7125 mL
    50 mM 0.0377 mL 0.1885 mL 0.377 mL 0.754 mL 0.9425 mL
    100 mM 0.0189 mL 0.0943 mL 0.1885 mL 0.377 mL 0.4713 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:1413575084
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:1148253675
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 10mg QQ客服:1413575084
    菊苣酸; Chicoric acid CFN99725 70831-56-0 C22H18O12 = 474.37 20mg QQ客服:1413575084
    1,5-二咖啡酰奎宁酸; 洋蓟素; 1,5-Dicaffeoylquinic acid CFN99123 30964-13-7 C25H24O12 = 516.45 20mg QQ客服:1413575084
    异绿原酸B; Isochlorogenic acid B CFN99119 14534-61-3 C25H24O12 = 516.45 20mg QQ客服:2932563308
    3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate CFN91970 143051-73-4 C27H28O12 = 544.50 5mg QQ客服:1413575084
    3,4-O-二咖啡酰基奎宁酸甲酯; 3,4-Di-O-caffeoylquinic acid methyl ester CFN90856 114637-83-1 C26H26O12 = 530.5 5mg QQ客服:215959384
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:215959384
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:215959384

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