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  • 人参皂苷Rk1

    Ginsenoside Rk1

    人参皂苷Rk1
    产品编号 CFN92644
    CAS编号 494753-69-4
    分子式 = 分子量 C42H70O12 = 767.0
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rk1 CFN92644 494753-69-4 10mg QQ客服:2159513211
    人参皂苷Rk1 CFN92644 494753-69-4 20mg QQ客服:2159513211
    人参皂苷Rk1 CFN92644 494753-69-4 50mg QQ客服:2159513211
    人参皂苷Rk1 CFN92644 494753-69-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Liège (Belgium)
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  • Nanjing University of Chinese Medicine (China)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Eastern Finland (Finland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • J Med Food.2016, 19(12):1155-1165
  • Int J Mol Sci.2017, 18(12)
  • J Bone Miner Res.2017, 32(12):2415-2430
  • FEMS Microbiol Lett.2017, 364(11)
  • Nutrients.2018, 10(12):E1998
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Sci Rep. 2018, 462(8)
  • Arch Biochem Biophys.2018, 644:93-99
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Analytical methods2019, 11(6)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • J Pharm Biomed Anal.2019, 172:268-277
  • Molecules.2019, 24(23):E4303
  • Molecules.2019, 24(4):E709
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Pak J Pharm Sci.2019, 32(6)
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • J Mater Chem B.2019, 7(39):5896-5919
  • J Clin Med.2019, 8(10):E1664
  • Sci Rep.2019, 9(1):4342
  • Biosci. Rep.2020, 10.1024
  • Plant Growth Regulation2020, 90(2):383-392
  • ...
  • 生物活性
    Description: Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity, the mechanism involves coordination between inhibition of telomerase activity and induction of apoptosis.
    Targets: Caspase | p53 | Bcl-2/Bax | c-Myc | ERK | Autophagy
    In vitro:
    Arch Pharm Res. 2012 Mar;35(4):717-22.
    Induction of apoptosis by ginsenoside Rk1 in SK-MEL-2-human melanoma.[Pubmed: 22553065]
    Ginsenosides are active compounds isolated from Panax ginseng Meyer. Among these ginsenosides, less polar ginsenosides such as ginsenoside Rg3 and ginsenoside Rh2 have been demonstrated to have tumor inhibitory effects because of their cytotoxicity.
    METHODS AND RESULTS:
    In this study, we evaluated the apoptotic effects of Ginsenoside Rk1 in SK-MEL-2 human melanoma. Ginsenoside Rk1 isolated from red ginseng is one of the novel ginsenosides that shows strong cytotoxicity compared to ginsenoside Rg3 in dose- and time-dependent manners. The results of DNA fragmentation, 4',6-diamidino-2-phenylindole staining, and flow cytometric analysis are corroborated that Ginsenoside Rk1 induced apoptosis in SK-MEL-2 cells. Western blot analysis revealed up-regulation of Fas, FasL, and Bax protein expression and down-regulation of procaspase-8, procaspase-3, mutant p53 and Bcl-2 protein expression.
    CONCLUSIONS:
    These findings suggest that Ginsenoside Rk1 might be a promising compound to induce apoptosis through both extrinsic and intrinsic pathways in SK-MEL-2 cells.
    Biol Pharm Bull. 2008 May;31(5):826-30.
    Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis.[Pubmed: 18451501]
    The Ginsenoside Rk1 is one of major components of heat-processed Panax ginseng C. A. MEYER, Sun Ginseng (SG).
    METHODS AND RESULTS:
    Here, we investigated the mechanisms underlying the anti-tumor activity of Ginsenoside Rk1 in human hepatocellular carcinoma HepG2 cells in vitro. Rk1 markedly inhibited telomerase activity and cell growth along with significant morphological change. The expression levels of telomerase reverse transcriptase (hTERT) and c-Myc mRNA were obviously decreased with Ginsenoside Rk1 treatment, while that of telomerase RNA (hTR) was not. Furthermore, Ginsenoside Rk1 induced apoptosis through activation of caspases-8 and -3. However, Fas-associated death domain (FADD) expression decreased with Ginsenoside Rk1 treatment, though it was known that the signaling cascade of FADD was associated with caspase-8 activity. Interestingly, activation of extracellular-regulated kinase (ERK) increased with Ginsenoside Rk1 treatment.
    CONCLUSIONS:
    In conclusion, these results represent the first identification of the biological activity of Ginsenoside Rk1 against HepG2 cell growth and show that the mechanism underlying the anti-tumor activity of Ginsenoside Rk1 involves coordination between inhibition of telomerase activity and induction of apoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3038 mL 6.5189 mL 13.0378 mL 26.0756 mL 32.5945 mL
    5 mM 0.2608 mL 1.3038 mL 2.6076 mL 5.2151 mL 6.5189 mL
    10 mM 0.1304 mL 0.6519 mL 1.3038 mL 2.6076 mL 3.2595 mL
    50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5215 mL 0.6519 mL
    100 mM 0.013 mL 0.0652 mL 0.1304 mL 0.2608 mL 0.3259 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    达玛二烯醇乙酸酯; Dammaradienyl acetate CFN98874 52914-31-5 C32H52O2 = 468.8 5mg QQ客服:3257982914
    人参皂苷Rk2; Ginsenoside Rk2 CFN92818 364779-14-6 C36H60O7 = 604.9 10mg QQ客服:3257982914
    人参皂苷Rk1; Ginsenoside Rk1 CFN92644 494753-69-4 C42H70O12 = 767.0 20mg QQ客服:1413575084
    人参皂苷Rh3; Ginsenoside Rh3 CFN99972 105558-26-7 C36H60O7 = 604.86 20mg QQ客服:3257982914
    人参皂苷Rg5; Ginsenoside Rg5 CFN92643 186763-78-0 C42H70O12 = 767.0 10mg QQ客服:1413575084
    人参皂苷Rk3; Ginsenoside Rk3 CFN92593 364779-15-7 C36H60O8 = 620.9 10mg QQ客服:1148253675
    人参皂苷Rg6; Ginsenoside Rg6 CFN90565 147419-93-0 C42H70O12 = 766.5 10mg QQ客服:215959384
    人参皂苷Rh4; Ginsenoside Rh4 CFN92594 174721-08-5 C36H60O8 = 620.9 10mg QQ客服:3257982914
    人参皂苷Rg4; Ginsenoside Rg4 CFN90572 126223-28-7 C42H70O12 = 767.0 5mg QQ客服:215959384
    3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene CFN99477 143519-04-4 C32H52O3 = 484.8 5mg QQ客服:2932563308

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