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  • 人参皂苷Rk3

    Ginsenoside Rk3

    人参皂苷Rk3
    产品编号 CFN92593
    CAS编号 364779-15-7
    分子式 = 分子量 C36H60O8 = 620.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rk3 CFN92593 364779-15-7 1mg QQ客服:3257982914
    人参皂苷Rk3 CFN92593 364779-15-7 5mg QQ客服:3257982914
    人参皂苷Rk3 CFN92593 364779-15-7 10mg QQ客服:3257982914
    人参皂苷Rk3 CFN92593 364779-15-7 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Celltrion Chemical Research Institute (Korea)
  • Sanford Burnham Medical Research Institute (USA)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Parma (Italy)
  • Universidad de Buenos Aires (Argentina)
  • University of Madras (India)
  • National Research Council of Canada (Canada)
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  • University of Vigo (Spain)
  • Hamdard University (India)
  • Universiti Sains Malaysia (Malaysia)
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  • Max Rubner-Institut (MRI) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2015, 5:13194
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Chemistr of plant2016, 2016021195
  • PLoS One.2017, 12(8):e0181191
  • BMC Complement Altern Med.2017, 17(1):393
  • Mol Cell.2017, 68(4):673-685
  • Exp Parasitol.2018, 194:67-78
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • RSC Adv.2018, 32621-32636
  • J Sep Sci.2018, 41(11):2488-2497
  • Arch Biochem Biophys.2018, 644:93-99
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Pathogens.2018, 7(3):E62
  • Front Cell Infect Microbiol.2018, 8:292
  • Int J Mol Sci.2019, 20(8):E1855
  • J Sep Sci.2019, 42(21):3352-3362
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Antioxidants (Basel).2019, 8(8):E307
  • Metabolites.2019, 9(11):E271
  • Sci Rep.2019, 9:12132
  • LWT-Food Sci Technol2020, 109163
  • Food Analytical Methods2020, 1-10
  • Int J Pharmacol2020, 16:1-9
  • ...
  • 生物活性
    Description: Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases, it could have a role in treating inflammatory diseases. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells.
    Targets: Bcl-2/Bax | Caspase | Akt | Nrf2 | HO-1 | MAPK | NF-κB
    In vitro:
    Evid Based Complement Alternat Med. 2013;2013:690190.
    Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway.[Pubmed: 23935671 ]
    Cardiac hypertrophy is a thickening of the heart muscle that is associated with cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as an adaptive process against increased workloads and often leads to sudden arrhythmic deaths. Studies suggest that the lethal arrhythmia is attributed to hypertrophy-induced destabilization of cardiac electrical activity, especially the prolongation of the action potential. The reduced activity of Ito is demonstrated to be responsible for the ionic mechanism of prolonged action potential duration and arrhythmogeneity. Isosteviol (STV), a derivative of stevioside, plays a protective role in a variety of stress-induced cardiac diseases.
    METHODS AND RESULTS:
    Here we report effects of STV on rat ISO-induced hypertrophic cardiomyocytes. STV alleviated ISO-induced hypertrophy of cardiomyocytes by decreasing cell area of hypertrophied cardiomyocytes. STV application prevented the prolongation of action potential which was prominent in hypertrophied cells.
    CONCLUSIONS:
    The decrease and increase of current densities for Ito and ICaL observed in hypertrophied myocytes were both prevented by STV application. In addition, the results of qRT-PCR suggested that the changes of electrophysiological activity of Ito and ICaL are correlated to the alterations of the mRNA transcription level.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6106 mL 8.0528 mL 16.1057 mL 32.2113 mL 40.2641 mL
    5 mM 0.3221 mL 1.6106 mL 3.2211 mL 6.4423 mL 8.0528 mL
    10 mM 0.1611 mL 0.8053 mL 1.6106 mL 3.2211 mL 4.0264 mL
    50 mM 0.0322 mL 0.1611 mL 0.3221 mL 0.6442 mL 0.8053 mL
    100 mM 0.0161 mL 0.0805 mL 0.1611 mL 0.3221 mL 0.4026 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    达玛二烯醇乙酸酯; Dammaradienyl acetate CFN98874 52914-31-5 C32H52O2 = 468.8 5mg QQ客服:2932563308
    人参皂苷Rk2; Ginsenoside Rk2 CFN92818 364779-14-6 C36H60O7 = 604.9 10mg QQ客服:1413575084
    人参皂苷Rk1; Ginsenoside Rk1 CFN92644 494753-69-4 C42H70O12 = 767.0 20mg QQ客服:215959384
    人参皂苷Rh3; Ginsenoside Rh3 CFN99972 105558-26-7 C36H60O7 = 604.86 20mg QQ客服:3257982914
    人参皂苷Rg5; Ginsenoside Rg5 CFN92643 186763-78-0 C42H70O12 = 767.0 10mg QQ客服:3257982914
    人参皂苷Rk3; Ginsenoside Rk3 CFN92593 364779-15-7 C36H60O8 = 620.9 10mg QQ客服:2159513211
    人参皂苷Rg6; Ginsenoside Rg6 CFN90565 147419-93-0 C42H70O12 = 766.5 10mg QQ客服:2932563308
    人参皂苷Rh4; Ginsenoside Rh4 CFN92594 174721-08-5 C36H60O8 = 620.9 10mg QQ客服:1413575084
    人参皂苷Rg4; Ginsenoside Rg4 CFN90572 126223-28-7 C42H70O12 = 767.0 5mg QQ客服:3257982914
    3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene CFN99477 143519-04-4 C32H52O3 = 484.8 5mg QQ客服:3257982914

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