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  • 人参皂苷Rh3

    Ginsenoside Rh3

    人参皂苷Rh3
    产品编号 CFN99972
    CAS编号 105558-26-7
    分子式 = 分子量 C36H60O7 = 604.86
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rh3 CFN99972 105558-26-7 10mg QQ客服:2159513211
    人参皂苷Rh3 CFN99972 105558-26-7 20mg QQ客服:2159513211
    人参皂苷Rh3 CFN99972 105558-26-7 50mg QQ客服:2159513211
    人参皂苷Rh3 CFN99972 105558-26-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hull (United Kingdom)
  • Kyoto University (Japan)
  • University of Virginia (USA)
  • National Cancer Institute (USA)
  • John Innes Centre (United Kingdom)
  • University of Maryland (USA)
  • University of East Anglia (United Kingdom)
  • National Hellenic Research Foundation (Greece)
  • National Research Council of Canada (Canada)
  • Universite Libre de Bruxelles (Belgium)
  • University of Hertfordshire (United Kingdom)
  • Worcester Polytechnic Institute (USA)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • S.N.D.T. Women's University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2014, 9(5):1653-9
  • Sci Rep.2015, 5:13194
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • SBRAS2016, 12
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Braz J Med Biol Res. 2016, 49(7)
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Preprints2017, 2017120176
  • Molecules.2017, 22(3)
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Arch Toxicol.2017, 91(10):3225-3245
  • J Hematol Oncol.2018, 11(1):112
  • Sci Rep. 2018, 1-9
  • Korean J of Medicinal Crop Science2018, 220-226
  • Molecules.2018, 23(7):E1659
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Front Pharmacol.2018, 9:756
  • Biomed Pharmacother.2019, 111:262-269
  • Enzyme Microb Technol.2019, 122:64-73
  • Int J Biol Macromol.2019, 126:653-661
  • Molecules.2019, 24(22):E4022
  • Environ Toxicol.2019, 34(12):1354-1362
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • ...
  • 生物活性
    Description: Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5, Rh3 has anti-inflammatory effect in microglia by modulating AMPK and its downstream signaling pathways, it may improve chronic dermatitis or psoriasis by the regulation of IL-1β and TNF-α produced by macrophage cells and of IFN-γ produced by Th cells. Rg5 and Rh3 inhibited acetylcholinesterase activity in a dose-dependent manner, with IC50 values of 18.4 and 10.2 uM, respectively, they may protect memory deficit by inhibiting AChE activity and increasing BDNF expression and CREB activation.
    Targets: COX | IFN-γ | IL Receptor | TNF-α | cAMP | PKC | NOS | HO-1 | PI3K | Akt | JAK | STAT | AMPK | NF-kB | Nrf2
    In vitro:
    Int J Biochem Cell Biol. 1998 Mar;30(3):327-38.
    Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2.[Pubmed: 9611775]
    Ginsenoside Rh3 and Rh4 were recently isolated from Panax ginseng, but their biochemical and pharmacological effects remain unidentified.
    METHODS AND RESULTS:
    The present study investigated whether the ginsenoside Rh group (G-Rh1, -Rh2, -Rh3 and -Rh4) having similar structures induce differentiation of HL-60 cells and whether protein kinase C (PKC) is involved in differentiation by ginsenoside. Differentiation was assessed by Wright-Giemsa stain and nitroblue tetrazolium reduction. G-Rh2 and Ginsenoside Rh3 induced differentiation of HL-60 cells into morphologically and functionally granulocytes but G-Rh1 and G-Rh4 did not. G-Rh2 and Ginsenoside Rh3 arrested the cell cycle at the G1/S phase, consistent with the ability to induce differentiation in a decreasing order of retinoic acid > G-Rh2 > Ginsenoside Rh3.
    CONCLUSIONS:
    It is concluded that G-Rh2 and Ginsenoside Rh3 can induce differentiation of HL-60 cells into granulocytes and modulation of PKC isoform levels may contribute to differentiation of HL-60 cells by G-Rh2.
    In vivo:
    Arch Pharm Res. 2006 Aug;29(8):685-90.
    Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model.[Pubmed: 16964764]
    The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated.
    METHODS AND RESULTS:
    Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5.
    CONCLUSIONS:
    These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6533 mL 8.2664 mL 16.5328 mL 33.0655 mL 41.3319 mL
    5 mM 0.3307 mL 1.6533 mL 3.3066 mL 6.6131 mL 8.2664 mL
    10 mM 0.1653 mL 0.8266 mL 1.6533 mL 3.3066 mL 4.1332 mL
    50 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.6613 mL 0.8266 mL
    100 mM 0.0165 mL 0.0827 mL 0.1653 mL 0.3307 mL 0.4133 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    达玛二烯醇乙酸酯; Dammaradienyl acetate CFN98874 52914-31-5 C32H52O2 = 468.8 5mg QQ客服:2932563308
    人参皂苷Rk2; Ginsenoside Rk2 CFN92818 364779-14-6 C36H60O7 = 604.9 10mg QQ客服:3257982914
    人参皂苷Rk1; Ginsenoside Rk1 CFN92644 494753-69-4 C42H70O12 = 767.0 20mg QQ客服:3257982914
    人参皂苷Rh3; Ginsenoside Rh3 CFN99972 105558-26-7 C36H60O7 = 604.86 20mg QQ客服:2932563308
    人参皂苷Rg5; Ginsenoside Rg5 CFN92643 186763-78-0 C42H70O12 = 767.0 10mg QQ客服:215959384
    人参皂苷Rk3; Ginsenoside Rk3 CFN92593 364779-15-7 C36H60O8 = 620.9 10mg QQ客服:1413575084
    人参皂苷Rg6; Ginsenoside Rg6 CFN90565 147419-93-0 C42H70O12 = 766.5 10mg QQ客服:2159513211
    人参皂苷Rh4; Ginsenoside Rh4 CFN92594 174721-08-5 C36H60O8 = 620.9 10mg QQ客服:2159513211
    人参皂苷Rg4; Ginsenoside Rg4 CFN90572 126223-28-7 C42H70O12 = 767.0 5mg QQ客服:2159513211
    3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene CFN99477 143519-04-4 C32H52O3 = 484.8 5mg QQ客服:1148253675

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