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  • 人参皂苷Rh4

    Ginsenoside Rh4

    人参皂苷Rh4
    产品编号 CFN92594
    CAS编号 174721-08-5
    分子式 = 分子量 C36H60O8 = 620.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rh4 CFN92594 174721-08-5 1mg QQ客服:215959384
    人参皂苷Rh4 CFN92594 174721-08-5 5mg QQ客服:215959384
    人参皂苷Rh4 CFN92594 174721-08-5 10mg QQ客服:215959384
    人参皂苷Rh4 CFN92594 174721-08-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Vienna (Austria)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Med. Plant Research.2013, 90-151
  • Food Science and Biotechnology2015, 2205-2212
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • HortTechnology2016, 26(6):816-819
  • Vojnosanit Pregl2016, 75(00):391-391
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • J Pharm Biomed Anal.2017, 140:274-280
  • Semyung University2017, 149407
  • University of Central Lancashire2017, 20472
  • Journal of Life Science2017, 233-240
  • J Food Compos Anal2017, 62:197-204
  • Microchemical Journal2018, 137:168-173
  • Lab Chip.2018, 18(6):971-978
  • Int J Mol Sci.2018, 19(9):E2601
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Molecules.2018, 23(7):E1659
  • Nat Prod Sci.2018, 24(2):109-114
  • BMB Rep.2018, 51(5):249-254
  • Eur J Pharmacol.2018, 832:96-103
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Planta Med.2019, 85(4):347-355
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy. Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect; it has cytotoxic activity and its aglycone against cancer cell lines.
    Targets: Caspase | Autophagy | Bcl-2/Bax
    In vivo:
    Chem Biodivers. 2007 Feb;4(2):232-40.
    Immunological adjuvant effect of ginsenoside Rh4 from the roots of Panax notoginseng on specific antibody and cellular response to ovalbumin in mice.[Pubmed: 17311234]

    METHODS AND RESULTS:
    Ginsenoside Rh4 (1), a saponin isolated from the roots of Panax notoginseng (Burk.) F. H. Chen, was evaluated for its haemolytic activity and adjuvant potential on specific antibody and cellular response to ovalbumin (OVA) in mice. Compound 1 showed a slight haemolytic effect, its concentration inducing 50% of the maximum haemolysis (HD(50) value) being 407+/-12 microg/ml using a 0.5% suspension of red blood cells. Ginsenoside Rh4 significantly increased the concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and OVA-induced splenocyte proliferation in OVA-immunized mice especially at a dose of 25 microg (P<0.05, P<0.01, or P<0.001). The OVA-specific serum IgG, IgG1, and IgG2b antibody levels were also significantly enhanced by 1 at a dose of 25 microg compared to the OVA control group (P<0.05 or P<0.01). Moreover, the enhancing effect of Ginsenoside Rh4 on the OVA-specific IgG2b antibody responses to OVA in mice was more significant than that of Alum (Al(OH)(3) gel; P<0.01).
    CONCLUSIONS:
    These results suggest that Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6106 mL 8.0528 mL 16.1057 mL 32.2113 mL 40.2641 mL
    5 mM 0.3221 mL 1.6106 mL 3.2211 mL 6.4423 mL 8.0528 mL
    10 mM 0.1611 mL 0.8053 mL 1.6106 mL 3.2211 mL 4.0264 mL
    50 mM 0.0322 mL 0.1611 mL 0.3221 mL 0.6442 mL 0.8053 mL
    100 mM 0.0161 mL 0.0805 mL 0.1611 mL 0.3221 mL 0.4026 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    达玛二烯醇乙酸酯; Dammaradienyl acetate CFN98874 52914-31-5 C32H52O2 = 468.8 5mg QQ客服:215959384
    人参皂苷Rk2; Ginsenoside Rk2 CFN92818 364779-14-6 C36H60O7 = 604.9 10mg QQ客服:1148253675
    人参皂苷Rk1; Ginsenoside Rk1 CFN92644 494753-69-4 C42H70O12 = 767.0 20mg QQ客服:3257982914
    人参皂苷Rh3; Ginsenoside Rh3 CFN99972 105558-26-7 C36H60O7 = 604.86 20mg QQ客服:3257982914
    人参皂苷Rg5; Ginsenoside Rg5 CFN92643 186763-78-0 C42H70O12 = 767.0 10mg QQ客服:1148253675
    人参皂苷Rk3; Ginsenoside Rk3 CFN92593 364779-15-7 C36H60O8 = 620.9 10mg QQ客服:3257982914
    人参皂苷Rg6; Ginsenoside Rg6 CFN90565 147419-93-0 C42H70O12 = 766.5 10mg QQ客服:1148253675
    人参皂苷Rh4; Ginsenoside Rh4 CFN92594 174721-08-5 C36H60O8 = 620.9 10mg QQ客服:2159513211
    人参皂苷Rg4; Ginsenoside Rg4 CFN90572 126223-28-7 C42H70O12 = 767.0 5mg QQ客服:2932563308
    3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene CFN99477 143519-04-4 C32H52O3 = 484.8 5mg QQ客服:1413575084

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