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  • 1,5-二咖啡酰奎宁酸

    1,5-Dicaffeoylquinic acid

    1,5-二咖啡酰奎宁酸
    产品编号 CFN90937
    CAS编号 19870-46-3
    分子式 = 分子量 C25H24O12 = 516.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Cynara scolymus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,5-二咖啡酰奎宁酸 CFN90937 19870-46-3 10mg QQ客服:215959384
    1,5-二咖啡酰奎宁酸 CFN90937 19870-46-3 20mg QQ客服:215959384
    1,5-二咖啡酰奎宁酸 CFN90937 19870-46-3 50mg QQ客服:215959384
    1,5-二咖啡酰奎宁酸 CFN90937 19870-46-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Lodz (Poland)
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  • Uniwersytet Gdański (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep. 2017, 8207(7)
  • Int Immunopharmacol.2020, 90:107268.
  • Food Chem.2017, 221:1135-1144
  • Food Bioscience2022, 50:102187.
  • Sci Rep.2016, 6:25094
  • J Agric Food Chem.2017, 65(13):2670-2676
  • Front Pharmacol.2021, 12:761922.
  • Antioxidants (Basel).2021, 10(1):112.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Int J Mol Sci.2022, 23(15):8687.
  • J Sep Sci.2018, 41(9):1938-1946
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Acta Biochim Pol.2015, 62(2):253-8
  • Korean j.of Pharm.2017, 70-76
  • J Ginseng Res.2022, 46(1):104-114.
  • Integr Cancer Ther.2018, 17(3):832-843
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • Biomolecules.2023, 13(2):227.
  • Nat Prod Sci.2019, 25(3):238
  • Mediators Inflamm. 2016, 2016:6189590
  • Int J Mol Sci.2019, 20(3):E651
  • Separations2021, 8(6),80.
  • Antioxidants (Basel).2020, 9(2):E99
  • ...
  • 生物活性
    Description: 1,5-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.It can significantly inhibit hOAT3 transport under similar conditions.
    Targets: ROS | hOAT3
    In vitro:
    Food Research International, 2009 , 42 (9) :1273-1280.
    Antioxidant activity of 1,3-dicaffeoylquinic acid isolated from Inula viscosa.[Reference: WebLink]
    Inula viscosa is a perennial herbaceous plant used topically in folk medicine as an anti-scabies, anti-inflammatory, and wound-healing agent.
    METHODS AND RESULTS:
    We examined the antioxidant activity of the methanolic extract of I. viscosa. We isolated and identified several polyphenolic antioxidants from I. viscosa leaves and focused on 1,3-Dicaffeoylquinic acid (1,3-diCQA). Antioxidant activity was measured using ABTS and DPPH assays, which measure antioxidant activity. The concentrations of 1,3-diCQA required for the inhibition of oxidation were lower than those required by other known antioxidants. 1,3-diCQA inhibited oxidative damage caused by various factors, including FeSO4 and AAPH (2,2'-azobis(2-amidinopropane) dehydrochloride). Antioxidant activity can also be detected by the ability of a compound to scavenge reactive oxygen species (ROS). 1,3-diCQA was found to scavenge hydroxyl radical and superoxide radicals, as measured by electron spin resonance (ESR).
    CONCLUSIONS:
    These data demonstrate that 1,3-diCQA exhibits antioxidant properties, probably through the involvement of a direct scavenging effect on several free radicals.
    In vivo:
    Evid Based Complement Alternat Med. 2013;2013:612527.
    Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).[Pubmed: 23573138]
    Active components of complementary/alternative medicines and natural supplements are often anionic compounds and flavonoids. As such, organic anion transporters (OATs) may play a key role in their pharmacokinetic and pharmacological profiles, and represent sites for adverse drug-drug interactions.
    METHODS AND RESULTS:
    Therefore, we assessed the inhibitory effects of nine natural products, including flavonoids (catechin and epicatechin), chlorogenic acids (1,3-Dicaffeoylquinic acid and 1,5-dicaffeoylquinic acid), phenolic acids (ginkgolic acids (13 : 0), (15 : 1), and (17 : 1)), and the organic acids ursolic acid and 18 β -glycyrrhetinic acid, on the transport activity of the human OATs, hOAT1 (SLC22A6), hOAT3 (SLC22A8), and hOAT4 (SLC22A11). Four compounds, 1,3- and 1,5-dicaffeoylquinic acid, ginkgolic acid (17 : 1), and 18 β -glycyrrhetinic acid, significantly inhibited hOAT1-mediated transport (50  μ M inhibitor versus 1  μ M substrate). Five compounds, 1,3- and 1,5-dicaffeoylquinic acid, ginkgolic acids (15 : 1) and (17 : 1), and epicatechin, significantly inhibited hOAT3 transport under similar conditions. Only catechin inhibited hOAT4. Dose-dependency studies were conducted for 1,3-Dicaffeoylquinic acid and 18 β -glycyrrhetinic acid on hOAT1, and IC50 values were estimated as 1.2 ± 0.4  μ M and 2.7 ± 0.2  μ M, respectively.
    CONCLUSIONS:
    These data suggest that 1,3-Dicaffeoylquinic acid and 18 β -glycyrrhetinic acid may cause significant hOAT1-mediated DDIs in vivo; potential should be considered for safety issues during use and in future drug development.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9361 mL 9.6805 mL 19.3611 mL 38.7222 mL 48.4027 mL
    5 mM 0.3872 mL 1.9361 mL 3.8722 mL 7.7444 mL 9.6805 mL
    10 mM 0.1936 mL 0.9681 mL 1.9361 mL 3.8722 mL 4.8403 mL
    50 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3872 mL 0.484 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:3257982914
    3,5-二咖啡酰-表-奎宁酸; 3,5-Dicaffeoyl-epi-quinic acid CFN91944 879305-14-3 C25H24O12 = 516.45 5mg QQ客服:3257982914
    3,5-O-二咖啡酰基奎宁酸甲酯; 3,5-Di-O-caffeoylquinic acid methyl ester CFN90857 159934-13-1 C26H26O12 = 530.5 5mg QQ客服:215959384
    异绿原酸C; Isochlorogenic acid C CFN99120 32451-88-0 C25H24O12 = 516.45 20mg QQ客服:3257982914
    异绿原酸C 4'-O-葡萄糖; Isochlorogenic acid C 4'-O-glucoside CFN95405 N/A C31H34O17 = 678.6 5mg QQ客服:2056216494
    4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester CFN90858 188742-80-5 C26H26O12 = 530.5 5mg QQ客服:2056216494
    3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid CFN90238 86632-03-3 C34H30O15 = 678.59 5mg QQ客服:1457312923
    单咖啡酰洒石酸; Caftaric acid CFN00384 67879-58-7 C13H12O9 = 312.2 20mg QQ客服:1457312923
    菊苣酸; Chicoric acid CFN99725 6537-80-0 C22H18O12 = 474.37 20mg QQ客服:1457312923
    1,4-二咖啡酰奎宁酸; 1,4-Dicaffeoylquinic acid CFN99122 1182-34-9 C25H24O12 = 516.46 5mg QQ客服:1457312923

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