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  • β-胡萝卜素

    Beta-Carotene

    β-胡萝卜素
    产品编号 CFN98117
    CAS编号 7235-40-7
    分子式 = 分子量 C40H56 = 536.88
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The roots of Daucus carota
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    β-胡萝卜素 CFN98117 7235-40-7 10mg QQ客服:1148253675
    β-胡萝卜素 CFN98117 7235-40-7 20mg QQ客服:1148253675
    β-胡萝卜素 CFN98117 7235-40-7 50mg QQ客服:1148253675
    β-胡萝卜素 CFN98117 7235-40-7 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Ohio State University (USA)
  • Ain Shams University (Egypt)
  • University of Ioannina (Greece)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Periyar University (India)
  • Charles University in Prague (Czech Republic)
  • The University of Newcastle (Australia)
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  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Kyung Hee University (Korea)
  • Macau University of Science and Technology (China)
  • Medizinische Universit?t Wien (Austria)
  • Seoul National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • Fitoterapia.2015, 100:179-86
  • Exp Parasitol.2015, 153:160-4
  • Chem Biol Interact.2016, 260:168-175
  • Acta horticulturae2017, 1158:257-268
  • Plant Methods.2017, 13:108
  • RSC Advances2017, 86
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Phytochemistry2018, 15:83-92
  • European Journal of Integrative Medicine2018, 20:165-172
  • J Ethnopharmacol.2018, 210:88-94
  • Phytomedicine.2018, 38:45-56
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Chinese Medicine2019, 14(1)
  • Int J Mol Sci.2019, 20(21):E5488
  • J Ethnopharmacol.2019, 228:132-141
  • J Ethnopharmacol.2019, 244:112074
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Phytother Res.2019, 33(4):1104-1113
  • Oncol Rep.2019, 41(4):2453-2463
  • New Journal of Chemistry2019, 43:12538-12547
  • J Clin Med.2019, 8(10):E1664
  • Food Res Int.2020, 128:108778
  • ...
  • 生物活性
    Description: Beta Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A. Beta-Carotene has antioxidant activity, anti-cancer, and antiapoptotic activities, it has protective effects against gamma-radiation-induced in vivo chromosomal damage. Dietary supplementation of carotenoids may act as moderate hypocholesterolemic agents, secondary to their inhibitory effect on macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase, the rate limiting enzyme in cholesterol synthesis.
    Targets: SOD | Caspase | LDL | HMG-CoA Reductase | MMP(e.g.TIMP) | HIF | GLUT
    In vitro:
    Biochem Biophys Res Commun. 1997 Apr 28;233(3):658-62.
    Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages.[Pubmed: 9168909 ]
    Beta-Carotene and lycopene are derived from plants, and they share similar initial synthetic pathway with cholesterol, which is synthesized in animal but not in plant cells. Thus, we sought to analyze the effect of carotenoids on macrophage cholesterol metabolism, in comparison to the effect of LDL cholesterol and of the cholesterol synthesis inhibitor, fluvastatin. In J-774 A. 1 macrophage cell line, the cellular cholesterol synthesis from [3H]-acetate, but not from [14C] mevalonate, was suppressed by 63% any by 73% following cell incubation with Beta-Carotene or lycopene (10 microM) respectively, in comparison to a 90% and 91% inhibition by LDL (100 micrograms of cholesterol), or by fluvastatin (10 micrograms/ml) respectively. However, unlike LDL derived cholesterol, which also suppresses macrophage LDL receptor activity, lycopene and Beta-Carotene augmented the activity of the macrophage LDL receptor, similarly to the effect of fluvasfatin. In agreement with these in vitro observations, dietary supplementation of tomato's lycopene (60 mg/day) to 6 males for a 3 months period resulted in a significant 14% reduction in their plasma LDL cholesterol concentrations.
    CONCLUSIONS:
    We thus conclude that dietary supplementation of carotenoids may act as moderate hypocholesterolemic agents, secondary to their inhibitory effect on macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase, the rate limiting enzyme in cholesterol synthesis.
    J Nutr Biochem. 2014 Jun;25(6):655-64.
    β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.[Pubmed: 24746828]
    While Beta-Carotene is a vitamin A precursor that has been shown to exert antioxidant and anticancer effects, the anti-metastatic effects of Beta-Carotene on neuroblastoma cells remain poorly understood. The aim of the present study was to investigate the anti-metastatic effects of Beta-Carotene on highly malignant SK-N-BE(2)C neuroblastoma cells in vitro and in vivo.
    METHODS AND RESULTS:
    Treatment of SK-N-BE(2)C cells with Beta-Carotene was found to attenuate the migratory and invasive capabilities of the cells. In addition, the enzymatic activity and expression of matrix metalloproteinase (MMP)-2 was suppressed following Beta-Carotene treatment under both normoxia and hypoxia. To induce metastasis, immunodeficient nude mice were injected with SK-N-BE(2)C cells via the tail vein in vivo. The incidence of liver metastasis and mean tumor volume in mice that were administered Beta-Carotene was decreased compared to controls. Furthermore, mRNA levels of MMPs, membrane-type (MT) 2 MMP and tissue inhibitors of metalloproteinases in liver tumor tissues were also lower following Beta-Carotene treatment. Level of hypoxia-inducible factor-1α (HIF-1α) and its downstream targets, vascular endothelial growth factor and glucose transporter 1 (GLUT1), were lower both in vitro and in vivo following Beta-Carotene treatment.
    CONCLUSIONS:
    In conclusion, the present study provides the first evidence that Beta-Carotene may represent an effective chemotherapeutic agent by regulating the invasion and metastasis of neuroblastoma via HIF-1α.
    In vivo:
    Mutat Res. 1993 Nov;303(3):109-12.
    Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage.[Pubmed: 7694126]
    The mouse bone marrow micronucleus test was carried out to evaluate the possible role of the dietary constituents chlorogenic acid (CGA), curcumin (CR) and beta-carotene (BC) in modulating the in vivo chromosomal damage induced by gamma-radiation.
    METHODS AND RESULTS:
    The results obtained suggest that oral administration of CGA (50, 100 and 200 mg/kg b.w.), CR (5, 10 and 20 mg/kg b.w.) and BC (0.5 and 2.5 mg/kg b.w.) to mice can significantly reduce the frequencies of micronucleated polychromatic erythrocytes (Mn PCEs) induced by whole body exposure to gamma-radiation (1.15 Gy; 0.05 Gy/s). With CGA and CR, this effect was observed after a single administration either 2 h before or immediately after irradiation. However, with BC a 7-day feeding before irradiation was necessary to obtain a significant reduction in the incidence of Mn PCEs.
    CONCLUSIONS:
    The protective effects of CGA, CR and BC were observed in bone marrow cells sampled 24, 30 and 48 h after exposure to radiation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8626 mL 9.3131 mL 18.6261 mL 37.2523 mL 46.5653 mL
    5 mM 0.3725 mL 1.8626 mL 3.7252 mL 7.4505 mL 9.3131 mL
    10 mM 0.1863 mL 0.9313 mL 1.8626 mL 3.7252 mL 4.6565 mL
    50 mM 0.0373 mL 0.1863 mL 0.3725 mL 0.745 mL 0.9313 mL
    100 mM 0.0186 mL 0.0931 mL 0.1863 mL 0.3725 mL 0.4657 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    β-隐黄素; beta-Cryptoxanthin CFN70370 472-70-8 C40H56O = 552.9 5mg QQ客服:1413575084
    辣椒红; Capsanthin CFN70366 465-42-9 C40H56O3 = 584.9 5mg QQ客服:3257982914
    虾青素; Astaxanthin CFN90096 472-61-7 C40H52O4 = 596.85 20mg QQ客服:2932563308
    叶黄素; Lutein CFN99384 127-40-2 C40H56O2 = 568.9 10mg QQ客服:2159513211
    土木香素; Helenien CFN70406 547-17-1 C72H116O4 = 1045.7 5mg QQ客服:1413575084
    玉米黄质; Zeaxanthin CFN90234 144-68-3 C40H56O2 = 568.88 5mg QQ客服:1148253675
    酸浆果红素; Physalien CFN70273 144-67-2 C72H116O4 = 1045.7 5mg QQ客服:2932563308
    α-胡萝卜素; alpha-Carotene CFN93610 7488-99-5 C40H56 = 536.87 5mg QQ客服:3257982914
    β-胡萝卜素; Beta-Carotene CFN98117 7235-40-7 C40H56 = 536.88 20mg QQ客服:3257982914
    岩藻黄质; Fucoxanthin CFN90852 3351-86-8 C42H58O6 = 658.9 10mg QQ客服:1413575084

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