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  • 虾青素

    Astaxanthin

    虾青素
    产品编号 CFN90096
    CAS编号 472-61-7
    分子式 = 分子量 C40H52O4 = 596.85
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Miscellaneous
    植物来源 From Haematococcus Pluvialis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    虾青素 CFN90096 472-61-7 10mg QQ客服:215959384
    虾青素 CFN90096 472-61-7 20mg QQ客服:215959384
    虾青素 CFN90096 472-61-7 50mg QQ客服:215959384
    虾青素 CFN90096 472-61-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Regional Crop Research Institute (Korea)
  • Universidade de Franca (Brazil)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Calcutta University (India)
  • Anna University (India)
  • Universidad Industrial de Santander (Colombia)
  • Universitas islam negeri Jakarta (Indonesia)
  • Istanbul University (Turkey)
  • Osmania University (India)
  • Deutsches Krebsforschungszentrum (Germany)
  • Subang Jaya Medical Centre (Malaysia)
  • Lodz University of Technology (Poland)
  • University of Virginia (USA)
  • Heidelberg University (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2015, 22(11):1027-36
  • J Pharm Biomed Anal.2016, 129:50-59
  • J Drug Target.2016, 24:1-28
  • Am J Chin Med.2016, 44(8):1719-1735
  • Front Pharmacol.2016, 7:460
  • Nutrients.2017, 10(1)
  • Molecules.2017, 22(2)
  • Biol Pharm Bull.2017, 40(6):797-806
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Anat Rec2018, 24264
  • Industrial Crops and Products2018, 353-362
  • Nutrients.2019, 12(1)
  • Nutr Res Pract2019, 13:e45
  • BMC Complement Altern Med.2019, 19(1):11
  • Molecules.2019, 24(11):E2044
  • Molecules.2019, 24(20):3755
  • Molecules.2019, 24(7):E1290
  • New Journal of Chemistry2019, 43:12538-12547
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Oxid Med Cell Longev2020, 12
  • J Pharmaceut Biomed2020, 178:112894
  • Journal of Chromatography A2020, 460942
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Astaxanthin is a strong antioxidant which shows neuroprotective property and can reduce the markers of inflammation, it can reduce matrix metalloproteinase expression in human chondrocytes, it may be beneficial in the treatment of osteoarthritis.Astaxanthin has protective effect on fetal alcohol spectrum disorder, and suggests that oxidative stress and TLR4 signaling associated inflammatory reaction are involved in this process. Astaxanthin administration can reduce renal calcium oxalate crystal deposition possibly by modulating the renal renin-angiotensin system (RAS), which reduces the expression of OPN and TGF-β1 levels.
    Targets: TLR | NF-kB | TNF-α | IL Receptor | TGF-β/Smad | MMP(e.g.TIMP) | p38MAPK | ERK
    In vitro:
    Int Immunopharmacol. 2014 Mar;19(1):174-7.
    Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes.[Pubmed: 24480614]
    Astaxanthin is a red carotenoid pigment which exerts multiple biological activities. However, little is known about the effects of astaxanthin on matrix metalloproteinases (MMPs) in OA.
    METHODS AND RESULTS:
    The present study investigated the effects of astaxanthin on MMPs in human chondrocytes. Human chondrocytes were pretreated with astaxanthin at 1, 10 or 50μM, then, cells were stimulated with IL-1β (10ng/ml) for 24h. MMP-1, MMP-3 and MMP-13 were observed. We found that astaxanthin reduced the expression of MMP-1, MMP-3 and MMP-13 as well as the phosphorylation of two mitogen-activated protein kinases (MAPK) (p38 and ERK1/2) in IL-1β-stimulated chondrocytes. Astaxanthin also blocked the IκB-α degradation.
    CONCLUSIONS:
    These results suggest that astaxanthin may be beneficial in the treatment of OA.
    In vivo:
    Metab Brain Dis. 2015 Jun 27.
    The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain.[Pubmed: 26116165]
    Astaxanthin is a potential antioxidant which shows neuroprotective property. We aimed to investigate the age-dependent and region-specific antioxidant effects of astaxanthin in mice brain.
    METHODS AND RESULTS:
    Animals were divided into 4 groups; treatment young (3 months, n = 6) (AY), treatment old (16 months, n = 6) (AO), placebo young (3 months, n = 6) (PY) and placebo old (16 months, n = 6) (PO) groups. Treatment group was given astaxanthin (2 mg/kg/day, body weight), and placebo group was given 100 μl of 0.9% normal saline orally to the healthy Swiss albino mice for 4 weeks. The level of non-enzymatic oxidative markers namely malondialdehyde (MDA); nitric oxide (NO); advanced protein oxidation product (APOP); glutathione (GSH) and the activity of enzymatic antioxidants i.e.; catalase (CAT) and superoxide dismutase (SOD) were determined from the isolated brain regions. Treatment with astaxanthin significantly (p < 0.05) reduces the level of MDA, APOP, NO in the cortex, striatum, hypothalamus, hippocampus and cerebellum in both age groups. Astaxanthin markedly (p < 0.05) enhances the activity of CAT and SOD enzymes while improves the level of GSH in the brain. Overall, improvement of oxidative markers was significantly greater in the young group than the aged animal.
    CONCLUSIONS:
    In conclusion, we report that the activity of astaxanthin is age-dependent, higher in young in compared to the aged brain.
    Rev Biol Trop. 2014 Dec;62(4):1331-41.
    The effect of astaxanthin on resistance of juvenile prawns Macrobrachium nipponense (Decapoda: Palaemonidae) to physical and chemical stress.[Pubmed: 25720170]
    In recent years, the use of new scientific techniques has effectively improved aquaculture production processes. Astaxanthin has various properties in aquaculture and its antioxidant benefits have been closely related to stress resistance; besides, it is an essential factor for growth in many crustaceans and fish. The objective of this study was to evaluate the resistance of prawn (Macrobrachium nipponense) fed diets containing different amounts of astaxanthin (AX) to the shock and stress of different physicochemical environments.
    METHODS AND RESULTS:
    A 70-day trial was conducted to evaluate the effect of supplementation of a source of astaxanthin (Carophyll Pink, 10% astaxanthin, w/w, Hoffman-La Roche, Switzerland) at various levels in the diet of M. nipponense juveniles. Four dry diets were prepared: AX0 without astaxanthin, AX50 with 50 mg/kg, AX100 with 100 mg/kg, and AX150 with 150 mg/kg astaxanthin. The feeding trial was conducted in a recirculation water system consisting of 12 fiberglass tanks (1000L) used for holding prawns. Three replicate aquaria were initially stocked with 36 org/m2 per tank. During the trial, prawns were maintained on a 12:12-h light:dark photoperiod with an ordinary incandescent lamp, and the water quality parameters were maintained as follows: water temperature, 25-26°C; salinity, 1 g/L; pH, 8.5-8.8; dissolved oxygen, 6.0-6.5 mg/L; and ammonia-nitrogen, 0.05 mg/L. Incorporation of AX, production output, and physiological condition were recorded after 10 weeks of feeding. At the end of the growing period, the prawns were exposed to thermal shock (0°C), ammonia (0.75 mg/L), and reduced oxygen (0.5 mg/L). The time to lethargy and the time to complete death of the prawns were recorded. The results showed that control prawns had the shortest time to lethargy and death compared with prawns subjected to the other treatments. The results of this study have shown that the amount of muscle tissue and gill carotenoids in prawn fed with an AX150 diet showed greater reduction than those exposed to other treatments. It is possible that higher levels of astaxanthin in the body under oxygen reduction stress can be beneficial for prawns.
    CONCLUSIONS:
    These results suggest that male prawns showed lethargy earlier than females, and the percentage of carotenoid reduction in muscle and gill tissues was higher in males.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6755 mL 8.3773 mL 16.7546 mL 33.5093 mL 41.8866 mL
    5 mM 0.3351 mL 1.6755 mL 3.3509 mL 6.7019 mL 8.3773 mL
    10 mM 0.1675 mL 0.8377 mL 1.6755 mL 3.3509 mL 4.1887 mL
    50 mM 0.0335 mL 0.1675 mL 0.3351 mL 0.6702 mL 0.8377 mL
    100 mM 0.0168 mL 0.0838 mL 0.1675 mL 0.3351 mL 0.4189 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    β-隐黄素; beta-Cryptoxanthin CFN70370 472-70-8 C40H56O = 552.9 5mg QQ客服:1413575084
    辣椒红; Capsanthin CFN70366 465-42-9 C40H56O3 = 584.9 5mg QQ客服:1413575084
    虾青素; Astaxanthin CFN90096 472-61-7 C40H52O4 = 596.85 20mg QQ客服:2159513211
    叶黄素; Lutein CFN99384 127-40-2 C40H56O2 = 568.9 10mg QQ客服:215959384
    土木香素; Helenien CFN70406 547-17-1 C72H116O4 = 1045.7 5mg QQ客服:1413575084
    玉米黄质; Zeaxanthin CFN90234 144-68-3 C40H56O2 = 568.88 5mg QQ客服:2932563308
    酸浆果红素; Physalien CFN70273 144-67-2 C72H116O4 = 1045.7 5mg QQ客服:1413575084
    α-胡萝卜素; alpha-Carotene CFN93610 7488-99-5 C40H56 = 536.87 5mg QQ客服:1413575084
    β-胡萝卜素; Beta-Carotene CFN98117 7235-40-7 C40H56 = 536.88 20mg QQ客服:2159513211
    岩藻黄质; Fucoxanthin CFN90852 3351-86-8 C42H58O6 = 658.9 10mg QQ客服:3257982914

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