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  • α-胡萝卜素

    alpha-Carotene

    α-胡萝卜素
    产品编号 CFN93610
    CAS编号 7488-99-5
    分子式 = 分子量 C40H56 = 536.87
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The roots of Daucus carota
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    α-胡萝卜素 CFN93610 7488-99-5 1mg QQ客服:1148253675
    α-胡萝卜素 CFN93610 7488-99-5 5mg QQ客服:1148253675
    α-胡萝卜素 CFN93610 7488-99-5 10mg QQ客服:1148253675
    α-胡萝卜素 CFN93610 7488-99-5 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Australian National University (Australia)
  • Harvard University (USA)
  • Sanford Burnham Medical Research Institute (USA)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Minnesota (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Universidad Industrial de Santander (Colombia)
  • University of Illinois (USA)
  • Nanjing University of Chinese Medicine (China)
  • University of Cincinnati (USA)
  • Seoul National University of Science and Technology (Korea)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Chang Gung University (Taiwan)
  • University of Indonesia (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Phytomedicine.2016, 23(4):331-9
  • Anal Bioanal Chem. 2016, 408(15)
  • Universidade Estadual Paulista2017, 11449
  • Molecules.2017, 22(2)
  • J Hematol Oncol.2018, 11(1):112
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Lab Chip.2018, 18(6):971-978
  • Chemistry of Natural Compounds2018, 204–206
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Clin Transl Oncol.2019, 10.1007
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • APMIS.2019, 127(10):688-695
  • J of Essential Oil Research2019, 1677272
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Int J Mol Sci.2019, 21(1):E265
  • Molecules.2019, 24(11):E2102
  • J Ethnopharmacol.2019, 244:112074
  • Academic J of Second Military Medical University2019, 40(1)
  • Antioxidants (Basel).2019, 8(8):E307
  • Planta Med.2019, 85(4):347-355
  • ...
  • 生物活性
    Description: alpha-Carotene has anti-metastasis activity, it inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO.
    Targets: FAK | MMP(e.g.TIMP) | MAPK
    In vitro:
    J Nutr Biochem. 2015 Jun;26(6):607-15.
    Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice.[Pubmed: 25736483 ]
    This study aimed to investigate the anti-metastatic activity of alpha-Carotene (AC) in Lewis lung carcinoma (LLC) and in combination with taxol in LLC-xenografted C57BL/6 mice.
    METHODS AND RESULTS:
    Cell culture studies reveal that AC significantly inhibited invasion, migration and activities of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator but increased protein expression of tissue inhibitor of MMP (TIMP)-1, -2 and plasminogen activator inhibitor (PAI)-1. These effects of AC are similar to those of β-carotene at the same concentration (2.5 μM). AC (2.5 μM) also significantly inhibited integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family. Findings from the animal model reveal that AC treatment (5m g/kg) alone significantly decreased lung metastasis without affecting primary tumor growth, whereas taxol treatment (6 mg/kg) alone exhibited significant inhibition on both actions, as compared to tumor control group. AC treatment alone significantly decreased protein expression of integrin β1 but increased protein expression of TIMP-1 and PAI-1 without affecting protein expression of TIMP-2 and phosphorylation of FAK in lung tissues, whereas taxol treatment alone significantly increased protein expression of TIMP-1, PAI-1 and TIMP-2 but decreased protein expression of integrin β1 and phosphorylation of FAK. The combined treatment produced stronger actions on lung metastasis and lung tissues protein expression of TIMP-1, TIMP-2 and PAI-1.
    CONCLUSIONS:
    Overall, we demonstrate that AC effectively inhibits LLC metastasis and suppresses lung metastasis in combination with taxol in LLC-bearing mice, suggesting that AC could be used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs.
    J Natl Cancer Inst. 1989 Nov 1;81(21):1649-52.
    Inhibitory effects of alpha-carotene on proliferation of the human neuroblastoma cell line GOTO.[Pubmed: 2795693]

    METHODS AND RESULTS:
    alpha-Carotene inhibited the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. In addition, it was about 10 times more inhibitory than beta-carotene. Northern blot analysis indicated that alpha-carotene caused maximum suppression of the level of the N-myc messenger RNA of GOTO cells. This suppression occurred within 18 hours of alpha-carotene treatment, after which the level of the N-myc messenger RNA gradually recovered to the basal level. Analysis by flow cytometry indicated that when GOTO cells were exposed to alpha-carotene, they were arrested in the G0-G1 phase of their cell cycle. However, as the level of the N-myc messenger RNA was recovering, these cells resumed normal cycling.
    CONCLUSIONS:
    These results indicate that the reduction in the level of the N-myc messenger RNA caused by alpha-carotene is closely linked with G0-G1 arrest.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8626 mL 9.3132 mL 18.6265 mL 37.253 mL 46.5662 mL
    5 mM 0.3725 mL 1.8626 mL 3.7253 mL 7.4506 mL 9.3132 mL
    10 mM 0.1863 mL 0.9313 mL 1.8626 mL 3.7253 mL 4.6566 mL
    50 mM 0.0373 mL 0.1863 mL 0.3725 mL 0.7451 mL 0.9313 mL
    100 mM 0.0186 mL 0.0931 mL 0.1863 mL 0.3725 mL 0.4657 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    β-隐黄素; beta-Cryptoxanthin CFN70370 472-70-8 C40H56O = 552.9 5mg QQ客服:1148253675
    辣椒红; Capsanthin CFN70366 465-42-9 C40H56O3 = 584.9 5mg QQ客服:2932563308
    虾青素; Astaxanthin CFN90096 472-61-7 C40H52O4 = 596.85 20mg QQ客服:215959384
    叶黄素; Lutein CFN99384 127-40-2 C40H56O2 = 568.9 10mg QQ客服:215959384
    土木香素; Helenien CFN70406 547-17-1 C72H116O4 = 1045.7 5mg QQ客服:1148253675
    玉米黄质; Zeaxanthin CFN90234 144-68-3 C40H56O2 = 568.88 5mg QQ客服:2932563308
    酸浆果红素; Physalien CFN70273 144-67-2 C72H116O4 = 1045.7 5mg QQ客服:215959384
    α-胡萝卜素; alpha-Carotene CFN93610 7488-99-5 C40H56 = 536.87 5mg QQ客服:2932563308
    β-胡萝卜素; Beta-Carotene CFN98117 7235-40-7 C40H56 = 536.88 20mg QQ客服:2159513211
    岩藻黄质; Fucoxanthin CFN90852 3351-86-8 C42H58O6 = 658.9 10mg QQ客服:1148253675

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