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  • 6,7-二羟基香豆素


    产品编号 CFN99115
    CAS编号 305-01-1
    分子式 = 分子量 C9H6O4 = 178.14
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The peels of Aesculus hippocastanum L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    6,7-二羟基香豆素 CFN99115 305-01-1 10mg QQ客服:1413575084
    6,7-二羟基香豆素 CFN99115 305-01-1 20mg QQ客服:1413575084
    6,7-二羟基香豆素 CFN99115 305-01-1 50mg QQ客服:1413575084
    6,7-二羟基香豆素 CFN99115 305-01-1 100mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • ...
  • 生物活性
    Description: 6,7-Dihydroxycoumarin(Esculetin) has various biological and pharmaceutical properties including anti-edema, anti-inflammatory, anti-tumour, hepatoprotective, anti-osteoarthritis and anti-rheumatoid arthritis effects. It inhibits lipoxygenases (LOs), p42/44 MAPK activation, PI3-kinase activation, as well as NF-kappaB and AP-1 activation, it exhibits competitive inhibition against the oxidation of 3-(3,4-dihydroxyphenyl)- alanine by mushroom, the IC50 value of is 43 microM.
    Targets: HO-1 | NO | AP-1 | MCP-1 | TNF-α | PPAR | NF-kB | PI3K
    In vitro:
    Int J Oncol. 2015 Jan;46(1):265-71.
    Esculetin (6,7-dihydroxycoumarin): a potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells.[Pubmed: 25310400]
    Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent.
    The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamous cell carcinoma (OSCC) cell lines, HN22 and HSC4, through regulation of specificity protein 1 (Sp1). We examined the apoptotic effects of esculetin were measured by MTS assay, DAPI staining, Annexin V, PI staining, RT-PCR, western blot analysis and immunocytochemistry in HN22 and HSC4 cells. Taken together, the results of the present study indicate that esculetin had anti-proliferative effect on the growth of OSCC cells (HN22 and HSC4) in a dose- and time-dependent manner. The treatment of HN22 and HSC4 cells with esculetin led to a significant reduction in growth and induced apoptosis, followed by the regulation of Sp1 and Sp1 regulatory protein.
    This indicates that esculetin inhibited cell growth and induced apoptosis by suppressing Sp1 in HN22 and HSC4 cells, suggesting it to be a potent anticancer drug candidate for oral cancer.
    Food Funct. 2014 Sep;5(9):2371-7.
    Esculetin inhibits the inflammatory response by inducing heme oxygenase-1 in cocultured macrophages and adipocytes.[Pubmed: 25088305]

    In this study, we investigated the anti-inflammatory effects of esculetin (6,7-dihydroxycoumarin,ECT) through up-regulation of heme oxygenase-1 (HO-1) in cocultured macrophages and adipocytes. RAW264.7 macrophages and differentiated 3T3-L1 adipocytes were cocultured in serum-free Dulbecco's modified Eagle's medium with or without ECT for 24 h. Nitric oxide (NO), tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) production was measured in the coculture supernatant. ECT decreased the secretion of NO, TNF-α, and MCP-1. The expression of adipogenic proteins, including peroxisome proliferator-activated receptors γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα) in cocultured adipocytes and inducible nitric oxide synthase (iNOS) in cocultured macrophages, was inhibited by ECT. Additionally, HO-1 expression was induced in cocultured macrophages and adipocytes. Silencing of HO-1 expression increased the production of NO, TNF-α, and MCP-1 in cocultured cells, in spite of the presence of ECT.
    This study demonstrated that ECT exhibited anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages through HO-1 expression. ECT may have the potential to improve chronic inflammation in obesity.
    Eur. J. Pharmacol., 1999, 370(3):297-305
    Esculetin suppresses proteoglycan metabolism by inhibiting the production of matrix metalloproteinases in rabbit chondrocytes.[Pubmed: 10334506]
    The possible mechanism of the chondroprotective effect of 6,7-dihydroxycoumarin (esculetin) was investigated using primary cultures of rabbit articular chondrocytes.
    Esculetin (EST) significantly suppressed the proteoglycan depletion and the release of pulse-labeled [35S]proteoglycan from the matrix layer of rabbit chondrocytes treated with recombinant human interleukin-1alpha. The matrix metalloproteinase inhibitor, 1,10-phenanthroline, also blocked the proteoglycan depletion and [35S]proteoglycan release. From these results, it is likely that recombinant human interleukin-1alpha-induced proteoglycan depletion is mediated by matrix metalloproteinases. Although esculetin did not directly inhibit collagenolytic activity in the culture media, it significantly suppressed the production of pro-matrix metalloproteinase-1/interstitial procollagenase and pro-matrix metalloproteinase-3/prostromelysin 1, accompanied by a decrease in the steady-state levels of their mRNAs.
    These results suggest that esculetin is a therapeutically effective candidate for inhibition of cartilage destruction in osteoarthritis and rheumatoid arthritis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6136 mL 28.0678 mL 56.1356 mL 112.2712 mL 140.3391 mL
    5 mM 1.1227 mL 5.6136 mL 11.2271 mL 22.4542 mL 28.0678 mL
    10 mM 0.5614 mL 2.8068 mL 5.6136 mL 11.2271 mL 14.0339 mL
    50 mM 0.1123 mL 0.5614 mL 1.1227 mL 2.2454 mL 2.8068 mL
    100 mM 0.0561 mL 0.2807 mL 0.5614 mL 1.1227 mL 1.4034 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    瑞香苷; Daphnin CFN80132 486-55-5 C15H16O9 = 340.3 5mg QQ客服:215959384
    瑞香素-7-甲醚; Daphnetin 7-methyl ether CFN90593 19492-03-6 C10H8O4 = 192.17 20mg QQ客服:2932563308
    7-羟基-8-甲氧基香豆素; Hydrangetin CFN89148 485-90-5 C10H8O4 = 192.17 5mg QQ客服:1413575084
    瑞香素二甲醚; Daphnetin dimethyl ether CFN90594 2445-80-9 C11H10O4 = 206.19 10mg QQ客服:1148253675
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服:3257982914
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服:215959384
    6,7-二羟基香豆素; 6,7-Dihydroxycoumarin CFN99115 305-01-1 C9H6O4 = 178.14 20mg QQ客服:215959384
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服:1148253675
    秦皮甲素; Esculin CFN99114 531-75-9 C15H16O9 = 340.28 20mg QQ客服:2932563308
    异莨菪亭; Isoscopoletin CFN97684 776-86-3 C10H8O4 = 192.17 20mg QQ客服:2932563308





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