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  • 异橄榄树脂素

    Cycloolivil

    异橄榄树脂素
    产品编号 CFN96185
    CAS编号 3064-05-9
    分子式 = 分子量 C20H24O7 = 376.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Maytenus hookeri Loes.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异橄榄树脂素 CFN96185 3064-05-9 1mg QQ客服:3257982914
    异橄榄树脂素 CFN96185 3064-05-9 5mg QQ客服:3257982914
    异橄榄树脂素 CFN96185 3064-05-9 10mg QQ客服:3257982914
    异橄榄树脂素 CFN96185 3064-05-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • Lodz University of Technology (Poland)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Seoul National University of Science and Technology (Korea)
  • Worcester Polytechnic Institute (USA)
  • University of British Columbia (Canada)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
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  • Shanghai Institute of Organic Chemistry (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomed Chromatogr.2019, 8:e4774
  • Int. J. of Food Properties2017, S108-S118
  • Eur J Pharmacol.2018, 832:96-103
  • Chemistry of Natural Compounds2020, 56,423-426
  • Oncology Letters2018, 4690-4696
  • Pak J Pharm Sci.2019, 32(6)
  • J Pharm Biomed Anal.2017, 140:274-280
  • Onco Targets Ther.2017, 10:3467-3474
  • American Association for Anatomy2020, doi: 10.1002.
  • Front Microbiol.2022, 13:835463.
  • Food and Fermentation Industries2019, 45(7):45-51
  • Cancer Manag Res.2019, 11:483-500
  • Phytochem Anal.2021, 32(6):970-981.
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Life (Basel).2021, 11(12):1399.
  • Phytomedicine.2019, 55:229-237
  • Front Immunol.2017, 8:1542
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Mol Cell.2017, 68(4):673-685
  • Int J Mol Sci.2020, 21(19),7070.
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • Nat Prod Communications2018, 10.1177
  • ...
  • 生物活性
    Description: (+)-Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated to platelet hyperaggregability and be the base for the development of antiaggregant therapeutic strategies.
    Targets: Calcium Channel
    In vitro:
    Blood Cell. Mol. Dis., 2009, 42(3):279-85.
    Olive tree wood phenolic compounds with human platelet antiaggregant properties.[Pubmed: 19195914]
    Oleuropein and (+)-Cycloolivil are natural polyphenolic compounds with a significant radical scavenging activity present in olive tree. We have investigated the antiaggregant effects of oleuropein and (+)-Cycloolivil isolated from an ethyl acetate extract of olive tree wood.
    METHODS AND RESULTS:
    Oleuropein and (+)-Cycloolivil reduced the ability of thrombin to stimulate platelet aggregation. Both compounds reduced thrombin-evoked Ca(2+) release and entry to a similar extent to hydroxytyrosol. This effect was greater in platelets from patients with type 2 diabetes mellitus than in controls. Thrombin-, thapsigargin- and 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ)-evoked protein tyrosine phosphorylation, which is involved in Ca(2+) signalling and platelet aggregation, is inhibited by oleuropein and (+)-Cycloolivil. oleuropein and (+)-Cycloolivil are natural oxygen radical scavengers that reduce thrombin-induced protein tyrosine phosphorylation, Ca(2+) signalling and platelet aggregation.
    CONCLUSIONS:
    These observations suggest that oleuropein and (+)-Cycloolivil may prevent thrombotic complications associated to platelet hyperaggregability and be the base for the development of antiaggregant therapeutic strategies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6567 mL 13.2837 mL 26.5675 mL 53.135 mL 66.4187 mL
    5 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
    10 mM 0.2657 mL 1.3284 mL 2.6567 mL 5.3135 mL 6.6419 mL
    50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
    100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.5313 mL 0.6642 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:3257982914
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:1413575084
    Vitedoin A; Vitedoin A CFN96448 819861-40-0 C20H20O6 = 356.37 5mg QQ客服:2932563308
    (-)-5'-甲氧基异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside CFN95403 143236-03-7 C27H36O12 = 552.6 5mg QQ客服:2159513211
    (+)-南烛木树脂酚; (+)-Lyoniresinol CFN99488 14464-90-5 C22H28O8 = 420.5 5mg QQ客服:3257982914
    南烛木糖甙; Lyoniside CFN98451 34425-25-7 C27H36O12 = 552.6 5mg QQ客服:2932563308
    (+)-南烛木树脂酚9'-O-葡萄糖甙; (+)-Lyoniresinol 9'-O-glucoside CFN97964 87585-32-8 C28H38O13 = 582.6 10mg QQ客服:1413575084
    (-)-Lyoniresinol 9'-O-glucoside ; (-)-Lyoniresinol 9'-O-glucoside CFN96732 143236-02-6 C28H38O13 = 582.59 5mg QQ客服:1413575084
    Nudiposide; Nudiposide CFN89146 62058-46-2 C27H36O12 = 552.57 5mg QQ客服:1148253675
    异紫杉脂素9,9'-缩丙酮; Isotaxiresinol 9,9'-acetonide CFN97774 252333-72-5 C22H26O6 = 386.44 5mg QQ客服:1148253675

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