反-甲基异丁香酚

trans-Methylisoeugenol

	产品编号	CFN96259
	CAS编号	6379-72-2
	分子式 = 分子量	C₁₁H₁₄O₂ = 178.2
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Phenylpropanoids
	植物来源	The roots of Atractylodes macrocephala
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
反-甲基异丁香酚	CFN96259	6379-72-2	1mg	QQ客服：2056216494
反-甲基异丁香酚	CFN96259	6379-72-2	5mg	QQ客服：2056216494
反-甲基异丁香酚	CFN96259	6379-72-2	10mg	QQ客服：2056216494
反-甲基异丁香酚	CFN96259	6379-72-2	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Florida International University (USA)

Celltrion Chemical Research Institute (Korea)

Wageningen University (Netherlands)

Chinese University of Hong Kong (China)

Universitas Airlangga (Indonesia)

Heinrich-Heine-University Düsseldorf (Germany)

University of Beira Interior (Portugal)

Seoul National University (Korea)

Complutense University of Madrid (Spain)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Aarhus University (Denmark)

Universita' Degli Studi Di Cagliari (Italy)

Universidad de Buenos Aires (Argentina)

Yale University (USA)

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Description:

(E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) can cause moderate reversible inhibition of glutathione S-transferases (GSTs)(I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).The use of isoeugenol methyl ether(trans-Methylisoeugenol) is described as an agent to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or to combat bad breath.

Targets:

5-HT Receptor

In vivo:

PAT-WO2006032664

Use of isoeugenol methyl ester as an agent against bad breath[Reference: WebLink]

METHODS AND RESULTS:
The use of isoeugenol methyl ether(trans-Methylisoeugenol)is described as an agent (i) to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or (ii) to combat bad breath.

Food Funct. 2014 Aug;5(8):1819-28.

Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.[Pubmed: 24920211 ]

(E)-methyl isoeugenol (MIE, trans-Methylisoeugenol) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for treating mood disorders appears to be globally attractive.
METHODS AND RESULTS:
Hence, we sought to evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects and the possible mechanisms of MIE actions. MIE at 250 and 500 mg kg(-1) potentiated the hypnotic effect of sodium pentobarbital. However, MIE did not protect against PTZ-induced convulsion. Except for MIE at 500 mg kg(-1), parameters evaluated in the LDB, EPM and OF demonstrated an anxiolytic like property of MIE. This effect was blocked by WAY100635 pretreatment. MIE at 500 mg kg(-1) elicited a reduction in locomotor activity of the mice in the OF. Anti-immobility effect of MIE 250 mg kg(-1) in the FST suggested an antidepressive like property. Unlike AMPT, pretreatment with PCPA reversed the antidepressant like effect of MIE.
CONCLUSIONS:
Our findings demonstrated anxiolytic and antidepressant like properties of (E)-methyl isoeugenol and suggested the participation of serotonergic pathways.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4-烯丙基儿茶酚; 4-(2-丙烯基)-1,2-苯二醇; 4-烯丙基-1,2-苯二醇; 4-Allylpyrocatechol	CFN99226	1126-61-0	C₉H₁₀O₂ = 150.2	20mg	QQ客服：1413575084
丁香酚; Eugenol	CFN99175	97-53-0	C₁₀H₁₂O₂ = 164.20	20mg	QQ客服：215959384
甲基丁香酚, 甲基丁子香酚 ; Methyleugenol	CFN96177	93-15-2	C₁₁H₁₄O₂ = 178.2	20mg	QQ客服：2056216494
水杨梅苷; Geoside	CFN95233	585-90-0	C₂₁H₃₀O₁₁ = 458.5	5mg	QQ客服：2159513211
顺式-甲基异丁香油酚; cis-Methylisoeugenol	CFN97095	6380-24-1	C₁₁H₁₄O₂ = 178.2	5mg	QQ客服：1457312923
反-甲基异丁香酚; trans-Methylisoeugenol	CFN96259	6379-72-2	C₁₁H₁₄O₂ = 178.2	5mg	QQ客服：1457312923
3,4-二甲氧基桂皮醇; 3,4-Dimethoxycinnamyl alcohol	CFN96231	40918-90-9	C₁₁H₁₄O₃ = 194.2	5mg	QQ客服：1457312923
4-丙基-2,6-二甲氧基苯酚; Syringylpropane	CFN92632	6766-82-1	C₁₁H₁₆O₃ = 196.2	5mg	QQ客服：3257982914
2,6-二甲氧基-4-(1E)-1-丙烯基苯基 beta-D-吡喃葡萄糖苷; Acantrifoside E	CFN96354	645414-25-1	C₁₇H₂₄O₈ = 356.4	5mg	QQ客服：2159513211
Pimentol; Pimentol	CFN90573	141913-95-3	C₂₃H₂₆O₁₂ = 494.5	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.6117 mL	28.0584 mL	56.1167 mL	112.2334 mL	140.2918 mL
5 mM	1.1223 mL	5.6117 mL	11.2233 mL	22.4467 mL	28.0584 mL
10 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
50 mM	0.1122 mL	0.5612 mL	1.1223 mL	2.2447 mL	2.8058 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL