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  • 反-甲基异丁香酚

    trans-Methylisoeugenol

    反-甲基异丁香酚
    产品编号 CFN96259
    CAS编号 6379-72-2
    分子式 = 分子量 C11H14O2 = 178.2
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenylpropanoids
    植物来源 The roots of Atractylodes macrocephala
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    反-甲基异丁香酚 CFN96259 6379-72-2 1mg QQ客服:215959384
    反-甲基异丁香酚 CFN96259 6379-72-2 5mg QQ客服:215959384
    反-甲基异丁香酚 CFN96259 6379-72-2 10mg QQ客服:215959384
    反-甲基异丁香酚 CFN96259 6379-72-2 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Julius Kühn-Institut (Germany)
  • University of Mysore (India)
  • National Cancer Institute (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Chulalongkorn University (Thailand)
  • Periyar University (India)
  • Aveiro University (Portugal)
  • University of Hertfordshire (United Kingdom)
  • University of Fribourg (Switzerland)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Macau University of Science and Technology (China)
  • Florida A&M University (USA)
  • Medizinische Universit?t Wien (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • Sci Rep.2017, 7:40345
  • Fitoterapia.2024, 106006.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Pharmaceutics.2022, 14(3):564.
  • PLoS One.2021, 16(6):e0248479.
  • Biomedicines.2020, 8(11):486.
  • Data Science for Genomics2023, 107-128.
  • Phytomedicine.2022, 102:154183.
  • Free Radic Biol Med.2017, 112:191-199
  • Acta Chromatographica2021, 00960.
  • Front Plant Sci.2021, 12:673337.
  • Chinese Journal of Tissue Engineering Research2024, 28(8):1149-1154.
  • Molecules.2020, 25(20):4851.
  • Food and Fermentation Industries2018, 44(371)
  • Sci Rep.2021, 11(1):11936.
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • mBio.2020, 11(3):e00686-20.
  • Life Sci.2021, 270:119074.
  • Mediators Inflamm. 2016, 2016:6189590
  • Wageningen University & Research2018, January 2018
  • Cells.2021, 10(10):2633.
  • ...
  • 生物活性
    Description: (E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) can cause moderate reversible inhibition of glutathione S-transferases (GSTs)(I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).The use of isoeugenol methyl ether(trans-Methylisoeugenol) is described as an agent to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or to combat bad breath.
    Targets: 5-HT Receptor
    In vivo:
    PAT-WO2006032664
    Use of isoeugenol methyl ester as an agent against bad breath[Reference: WebLink]

    METHODS AND RESULTS:
    The use of isoeugenol methyl ether(trans-Methylisoeugenol)is described as an agent (i) to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or (ii) to combat bad breath.
    Food Funct. 2014 Aug;5(8):1819-28.
    Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.[Pubmed: 24920211 ]
    (E)-methyl isoeugenol (MIE, trans-Methylisoeugenol) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for treating mood disorders appears to be globally attractive.
    METHODS AND RESULTS:
    Hence, we sought to evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects and the possible mechanisms of MIE actions. MIE at 250 and 500 mg kg(-1) potentiated the hypnotic effect of sodium pentobarbital. However, MIE did not protect against PTZ-induced convulsion. Except for MIE at 500 mg kg(-1), parameters evaluated in the LDB, EPM and OF demonstrated an anxiolytic like property of MIE. This effect was blocked by WAY100635 pretreatment. MIE at 500 mg kg(-1) elicited a reduction in locomotor activity of the mice in the OF. Anti-immobility effect of MIE 250 mg kg(-1) in the FST suggested an antidepressive like property. Unlike AMPT, pretreatment with PCPA reversed the antidepressant like effect of MIE.
    CONCLUSIONS:
    Our findings demonstrated anxiolytic and antidepressant like properties of (E)-methyl isoeugenol and suggested the participation of serotonergic pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6117 mL 28.0584 mL 56.1167 mL 112.2334 mL 140.2918 mL
    5 mM 1.1223 mL 5.6117 mL 11.2233 mL 22.4467 mL 28.0584 mL
    10 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
    50 mM 0.1122 mL 0.5612 mL 1.1223 mL 2.2447 mL 2.8058 mL
    100 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芹菜脑; Apioline CFN70479 523-80-8 C12H14O4 = 222.2 20mg QQ客服:3257982914
    α-细辛脑; alpha-Asarone CFN93217 2883-98-9 C12H16O3 = 208.25 20mg QQ客服:2056216494
    (Z)-1,2,4-三甲氧基-5- 丙烯基苯; 顺式细辛脑; beta-Asarone CFN98870 5273-86-9 C12H16O3 = 208.3 5mg QQ客服:215959384
    Gamma-细辛醚; Gamma-Asarone CFN91475 5353-15-1 C12H16O3 = 208.3 10mg QQ客服:215959384
    赤式-1',2'-二羟基细辛醚; Erythro-1',2'-dihydroxyasarone CFN95655 146830-05-9 C12H18O5 = 242.3 5mg QQ客服:2056216494
    苏式-1',2'-二羟基细辛醚; Threo-1',2'-dihydroxyasarone CFN95656 N/A C12H18O5 = 242.3 10mg QQ客服:215959384
    茴香脑; Anethole CFN98550 104-46-1 C10H12O = 148.2 20mg QQ客服:215959384
    4-烯丙基儿茶酚; 4-(2-丙烯基)-1,2-苯二醇; 4-烯丙基-1,2-苯二醇; 4-Allylpyrocatechol CFN99226 1126-61-0 C9H10O2 = 150.2 20mg QQ客服:3257982914
    丁香酚; Eugenol CFN99175 97-53-0 C10H12O2 = 164.20 20mg QQ客服:2159513211
    甲基丁香酚, 甲基丁子香酚 ; Methyleugenol CFN96177 93-15-2 C11H14O2 = 178.2 20mg QQ客服:1413575084

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