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  • α-细辛脑

    alpha-Asarone

    α-细辛脑
    产品编号 CFN93217
    CAS编号 2883-98-9
    分子式 = 分子量 C12H16O3 = 208.25
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The seeds of Daucus carota
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    α-细辛脑 CFN93217 2883-98-9 10mg QQ客服:2159513211
    α-细辛脑 CFN93217 2883-98-9 20mg QQ客服:2159513211
    α-细辛脑 CFN93217 2883-98-9 50mg QQ客服:2159513211
    α-细辛脑 CFN93217 2883-98-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • VIT University (India)
  • Seoul National University of Science and Technology (Korea)
  • Chang Gung University (Taiwan)
  • Universidad de Antioquia (Colombia)
  • University of Toronto (Canada)
  • Sapienza University of Rome (Italy)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Cornell University (USA)
  • Anna University (India)
  • Istanbul University (Turkey)
  • Universitas islam negeri Jakarta (Indonesia)
  • Complutense University of Madrid (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals (Basel).2024, 17(4):442.
  • Separations2023, 10(11), 567;
  • J Breast Cancer.2015, 18(2):112-118
  • Adaptive Medicine 2020, 12(1): 4-10
  • Industrial Crops and Products2018, 353-362
  • Nutrients.2021, 13(12):4364.
  • J. of Agricultural Science2015, 1916-9760
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Asian J Beauty Cosmetol2024, 22(1): 103-112.
  • J Nat Med.2020, 74(3):550-560.
  • Molecules.2022, 27(5):1675
  • Metabolites2022, 12(6),507.
  • Pharmacogn Mag.2015, 11(43):562-6
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Appl Biol Chem2019, 62:46
  • J Pharm Biomed Anal.2018, 151:32-41
  • Food Chem Toxicol.2023, 176:113802.
  • Pharmacol Rep.2022, 74(1):175-188.
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • Analytical sci. & Tech2020, 33(5):224-231
  • J Korean Med Obes Res.2023, 23:10-7
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Int J Mol Sci.2015, 16(8):18396-411
  • ...
  • 生物活性
    Description: alpha-Asarone has antioxidant activity, it effectively reversed MDR by inhibiting P-gp function and expression. alpha-Asarone protects against Ang II-mediated damage of endothelial cells and may be developed to prevent injury to cardiovascular tissues. Alpha-asarone congeners as hypolipidemic agents, they appeared to be promising for the treatment of human hyperlipidaemia and thrombotic diseases.Alpha-asarone also attenuates depression-like behavior in nicotine-withdrawn mice.
    Targets: P-gp | ROS | NO | eNOS | LDL | SOD | GPx | pCREB | BDNF
    In vitro:
    BIOTECHNOLOGY LETTERS, 2014, 36(4):685.
    Reversing P-glycoprotein-mediated multidrug resistance in vitro by α-asarone and β-asarone, bioactive cis–trans isomers from Acorus tatarinowii.[Reference: WebLink]
    P-Glycoprotein (P-gp), an ATP-binding cassette transporter, plays an important role in multidrug resistance (MDR).
    METHODS AND RESULTS:
    alpha-Asarone and β-asarone, bioactive cis–trans isomers found in Acorus tatarinowii Schott, were tested for their potential ability to modulate the expression and function of P-gp in Caco-2 cells. MTT assays revealed that both alpha-Asarone and β-asarone significantly enhanced the vincristine-induced cytotoxicity to cells. β-Asarone was the most potent. Flow cytometry showed that alpha-Asarone and β-asarone increased Rhodamine 123 (Rh123) uptake and inhibited Rh123 efflux in Caco-2 cells in a concentration-dependent manner. Furthermore, P-gp expression and P-gp mRNA in cells were decreased by exposure to alpha-Asarone and β-asarone. In addition, β-asarone increased the inhibition of P-gp activity in cells more than α-asarone.
    CONCLUSIONS:
    Thus, alpha-Asarone and β-asarone effectively reversed MDR by inhibiting P-gp function and expression.
    Evidence-Based Complementary and Alternative Medicine, 2014, 2014:1-7.
    Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II.[Pubmed: 24757494 ]
    alpha-Asarone is the major therapeutical constituent of Acorus tatarinowii Schott.
    METHODS AND RESULTS:
    In this study, the potential protective effects of alpha-Asarone against endothelial cell injury induced by angiotensin II were investigated in vitro. The EA.hy926 cell line derived from human umbilical vein endothelial cells was pretreated with alpha-Asarone (10, 50, 100 µmol/L) for 1 h, followed by coincubation with Ang II (0.1 µmol/L) for 24 h. Intracellular nitric oxide (NO) and reactive oxygen species (ROS) were detected by fluorescent dyes, and phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177 was determined by Western blotting. alpha-Asarone dose-dependently mitigated the Ang II-induced intracellular NO reduction (P < 0.01 versus model) and ROS production (P < 0.01 versus model). Furthermore, eNOS phosphorylation (Ser1177) by acetylcholine was significantly inhibited by Ang II, while pretreatment for 1 h with alpha-Asarone partially prevented this effect (P < 0.05 versus model). Additionally, cell viability determined by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay (105~114.5% versus control, P > 0.05) was not affected after 24 h of incubation with α-asarone at 1–100 µmol/L.
    CONCLUSIONS:
    Therefore, alpha-Asarone protects against Ang II-mediated damage of endothelial cells and may be developed to prevent injury to cardiovascular tissues.
    In vivo:
    Journal of Pharmacy & Pharmacology, 2010, 58(10):1343-1349.
    Hypolipidaemic and antiplatelet activity of phenoxyacetic acid derivatives related to α-asarone.[Reference: WebLink]
    The phenoxyacetic acid derivatives 1-6 [2-methoxy-4-(2-propenyl)phenoxyacetic acid (1); 2-methoxy-5-nitro-4-(2-propenyl)phenoxyacetic acid (2); methyl 2-methoxy-4-(2-propenyl)phenoxyacetate (3); ethyl 2-methoxy-4-(2-propenyl)phenoxyacetate (4); methyl 2-methoxy-5-nitro-4-(2-propenyl)phenoxyacetate (5); ethyl 2-methoxy-5-nitro-4-(2-propenyl)phenoxyacetate (6)] related to alpha-asarone have been reported previously as hypolipidaemic agents in diet-induced hyperlipidaemic mice. We have aimed to expand the pharmacological profile of these derivatives by investigating their hypolipidaemic activity in rats and mice under different experimental conditions. The antiplatelet activity was tested also in-vitro from blood derived from consenting healthy volunteers.
    METHODS AND RESULTS:
    In normolipidaemic rats, compounds 2, 3 and 5 at oral doses of 40 and 80 mg kg(-1) significantly decreased total cholesterol and LDL-cholesterol levels. Moreover, analogues 3 and 5 administered to hypercholesterolaemic rats at the same doses for seven days also produced a reduction in the content of these same lipoproteins. In neither case were the high-density lipoprotein cholesterol and triglyceride concentrations affected. However, practically all tested compounds were found to be hypocholesterolaemic agents, and were shown to effectively lower low-density lipoprotein cholesterol and triglyceride levels in Triton-induced hyperlipidaemic mice at oral doses of 50 and 100 mg kg(-1).
    CONCLUSIONS:
    In all tests, all animals appeared to be healthy throughout the experimental period in their therapeutic ranges. Triton-induced hypercholesterolaemic mice appeared to be a desirable model for this class of hypolipidaemic drugs. On the other hand, compounds 1, 2, 4 and 5 significantly inhibited ADP-induced aggregation in-vitro. These findings indicated that all of these compounds appeared to be promising for the treatment of human hyperlipidaemia and thrombotic diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8019 mL 24.0096 mL 48.0192 mL 96.0384 mL 120.048 mL
    5 mM 0.9604 mL 4.8019 mL 9.6038 mL 19.2077 mL 24.0096 mL
    10 mM 0.4802 mL 2.401 mL 4.8019 mL 9.6038 mL 12.0048 mL
    50 mM 0.096 mL 0.4802 mL 0.9604 mL 1.9208 mL 2.401 mL
    100 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苏式-1',2'-二羟基细辛醚; Threo-1',2'-dihydroxyasarone CFN95656 N/A C12H18O5 = 242.3 10mg QQ客服:2159513211
    茴香脑; Anethole CFN98550 104-46-1 C10H12O = 148.2 20mg QQ客服:215959384
    4-烯丙基儿茶酚; 4-(2-丙烯基)-1,2-苯二醇; 4-烯丙基-1,2-苯二醇; 4-Allylpyrocatechol CFN99226 1126-61-0 C9H10O2 = 150.2 20mg QQ客服:215959384
    丁香酚; Eugenol CFN99175 97-53-0 C10H12O2 = 164.20 20mg QQ客服:3257982914
    甲基丁香酚, 甲基丁子香酚 ; Methyleugenol CFN96177 93-15-2 C11H14O2 = 178.2 20mg QQ客服:3257982914
    水杨梅苷; Geoside CFN95233 585-90-0 C21H30O11 = 458.5 5mg QQ客服:1413575084
    顺式-甲基异丁香油酚; cis-Methylisoeugenol CFN97095 6380-24-1 C11H14O2 = 178.2 5mg QQ客服:3257982914
    反-甲基异丁香酚; trans-Methylisoeugenol CFN96259 6379-72-2 C11H14O2 = 178.2 5mg QQ客服:2159513211
    3,4-二甲氧基桂皮醇; 3,4-Dimethoxycinnamyl alcohol CFN96231 40918-90-9 C11H14O3 = 194.2 5mg QQ客服:1413575084
    4-丙基-2,6-二甲氧基苯酚; Syringylpropane CFN92632 6766-82-1 C11H16O3 = 196.2 5mg QQ客服:215959384

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