ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid

	产品编号	CFN89078
	CAS编号	57719-81-0
	分子式 = 分子量	C₂₀H₂₈O₄ = 332.44
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Pteris Semipinnata L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	CFN89078	57719-81-0	1mg	QQ客服：2159513211
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	CFN89078	57719-81-0	5mg	QQ客服：2159513211
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	CFN89078	57719-81-0	10mg	QQ客服：2159513211
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	CFN89078	57719-81-0	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Deutsches Krebsforschungszentrum (Germany)

University of Stirling (United Kingdom)

University of Perugia (Italy)

Center for protein Engineering (CIP) (Belgium)

Chungnam National University (Korea)

University of Cincinnati (USA)

Universita' Degli Studi Di Cagliari (Italy)

Shanghai Institute of Biochemistry and Cell Biology (China)

MTT Agrifood Research Finland (Finland)

Medizinische Universit?t Wien (Austria)

Kyushu University (Japan)

Korea Intitute of Science and Technology (KIST) (Korea)

Florida International University (USA)

Universiti Putra Malaysia(UPM) (Malaysia)

More...

Description:

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.

Targets:

p65 | NF-kB | Bcl-2/Bax | ERK | p53 | p38MAPK | Caspase | JNK

In vitro:

Invest New Drugs. 2012 Dec;30(6):2210-8.

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.[Pubmed: 22227815 ]

ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid(5F) isolated from Pteris Semipinnata L is known to inhibit certain tumor cells in vitro. The information on the in vivo effect of 5F is limited and its effect on hepatocellular carcinoma (HCC) is unknown.
METHODS AND RESULTS:
In this study, the anti-tumor effect of 5F was investigated in a diethylnitrosamine (DEN)-induced mouse HCC model. In addition to therapeutic effect, the potential side effect was monitored. A panel of cultured HCC cells was used to confirm the in vivo data and explore the responsible molecular pathway. The result showed that 5F significantly inhibited the DEN-induced HCC tumors by reducing the number of tumor foci and the volume of tumors. Furthermore, 5F induced the death of cultured HCC cells in dose- and time-dependent manners. The cell death was confirmed to be apoptotic by in vivo and in vitro TUNEL assays. 5F inhibited NF-kB by stabilizing its inhibitor IkBα, reducing the nuclear p65 and inhibiting NF-kB activity. Subsequently it affected the NF-kB downstream molecules with a decrease in anti-apoptotic Bcl-2 and increase in pro-apoptotic Bax and Bak. During the whole period of the experiment, mice receiving 5F appeared to be healthy, though they suffered from a mild degree of hair loss. 5F did not damage liver and renal functions.
CONCLUSIONS:
In conclusion, 5F is effective against HCC with minimal side effects. It induces apoptosis in HCC cells via inhibiting NF-kB, leading to the decrease of Bcl-2 but the increase of Bax and Bak.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Deacetylxylopic acid; Deacetylxylopic acid	CFN97131	6619-95-0	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：2159513211
11,15-二羟基-16-贝壳杉烯-19-酸; 11,15-Dihydroxy-16-kauren-19-oic acid	CFN98977	57719-76-3	C₂₀H₃₀O₄ = 334.5	5mg	QQ客服：215959384
对映-9-羟基-15-氧代-16-贝壳杉烯-19-酸; ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid	CFN97261	77658-39-0	C₂₀H₂₈O₄ = 332.4	5mg	QQ客服：2056216494
对映-6,9-二羟基-15-氧代-16-贝壳杉烯-19-酸; ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid	CFN97294	81264-00-8	C₂₀H₂₈O₅ = 348.4	5mg	QQ客服：2056216494
ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide; ent-7alpha,9-Dihydroxy-15-oxokaur-16-en-19,6bet-olide	CFN89107	59885-89-1	C₂₀H₂₆O₅ = 346.42	5mg	QQ客服：2159513211
Pterisolic acid A; Pterisolic acid A	CFN97975	1401419-85-9	C₂₀H₂₆O₅ = 346.4	5mg	QQ客服：215959384
Pterisolic acid B; Pterisolic acid B	CFN97976	1401419-86-0	C₂₀H₂₆O₄ = 330.4	5mg	QQ客服：2159513211
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid; ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	CFN89078	57719-81-0	C₂₀H₂₈O₄ = 332.44	5mg	QQ客服：1457312923
Paniculoside III; Paniculoside III	CFN89216	60129-65-9	C₂₆H₃₈O₉ = 494.58	5mg	QQ客服：1457312923
(3alpha,4beta,15alpha)-贝壳杉-16-烯-3,15,18-三醇; ent-16-Kaurene-3beta,15beta,18-triol	CFN96331	921211-29-2	C₂₀H₃₂O₃ = 320.5	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0081 mL	15.0403 mL	30.0806 mL	60.1612 mL	75.2015 mL
5 mM	0.6016 mL	3.0081 mL	6.0161 mL	12.0322 mL	15.0403 mL
10 mM	0.3008 mL	1.504 mL	3.0081 mL	6.0161 mL	7.5202 mL
50 mM	0.0602 mL	0.3008 mL	0.6016 mL	1.2032 mL	1.504 mL
100 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.6016 mL	0.752 mL