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  • ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid

    • ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid

    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid

    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
    		产品编号 CFN89078
    CAS编号 57719-81-0
    分子式 = 分子量 C20H28O4 = 332.44
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Pteris Semipinnata L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid CFN89078 57719-81-0 1mg QQ客服：3257982914
    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid CFN89078 57719-81-0 5mg QQ客服：3257982914
    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid CFN89078 57719-81-0 10mg QQ客服：3257982914
    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid CFN89078 57719-81-0 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(10):5813.
  • J Biosci.2020, 45:46.
  • Fitoterapia.2024, 175:105958.
  • Front Plant Sci.2020, 10:1705
  • Journal of Ginseng Research2021, 3 June.
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  • Eur J Pharmacol.2024, 963:176280.
  • Molecules.2017, 22(11)
  • Phytomedicine.2015, 22(14):1262-8
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Food Chem.2024, 436:137768.
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • Kaohsiung J Med Sci.2024, 40(3):280-290.
  • Int J Mol Sci.2018, 19(9):E2825
  • Int. J. of Food Properties2017, S108-S118
  • Food Chem.2017, 221:1135-1144
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Separation Science & Technology2016, 51:1579-1588
  • Applied Biological Chemistry2020, 63:33(2020)
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • Sci Rep.2023, 13(1):13072.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • J Clin Med.2019, 8(10):E1664
  • ...
    • 生物活性
    Description: Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.
    Targets: p65 | NF-kB | Bcl-2/Bax | ERK | p53 | p38MAPK | Caspase | JNK
    In vitro:
    Invest New Drugs. 2012 Dec;30(6):2210-8.
    Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.[Pubmed: 22227815 ]
    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid(5F) isolated from Pteris Semipinnata L is known to inhibit certain tumor cells in vitro. The information on the in vivo effect of 5F is limited and its effect on hepatocellular carcinoma (HCC) is unknown.
    METHODS AND RESULTS:
    In this study, the anti-tumor effect of 5F was investigated in a diethylnitrosamine (DEN)-induced mouse HCC model. In addition to therapeutic effect, the potential side effect was monitored. A panel of cultured HCC cells was used to confirm the in vivo data and explore the responsible molecular pathway. The result showed that 5F significantly inhibited the DEN-induced HCC tumors by reducing the number of tumor foci and the volume of tumors. Furthermore, 5F induced the death of cultured HCC cells in dose- and time-dependent manners. The cell death was confirmed to be apoptotic by in vivo and in vitro TUNEL assays. 5F inhibited NF-kB by stabilizing its inhibitor IkBα, reducing the nuclear p65 and inhibiting NF-kB activity. Subsequently it affected the NF-kB downstream molecules with a decrease in anti-apoptotic Bcl-2 and increase in pro-apoptotic Bax and Bak. During the whole period of the experiment, mice receiving 5F appeared to be healthy, though they suffered from a mild degree of hair loss. 5F did not damage liver and renal functions.
    CONCLUSIONS:
    In conclusion, 5F is effective against HCC with minimal side effects. It induces apoptosis in HCC cells via inhibiting NF-kB, leading to the decrease of Bcl-2 but the increase of Bax and Bak.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0081 mL 15.0403 mL 30.0806 mL 60.1612 mL 75.2015 mL
    5 mM 0.6016 mL 3.0081 mL 6.0161 mL 12.0322 mL 15.0403 mL
    10 mM 0.3008 mL 1.504 mL 3.0081 mL 6.0161 mL 7.5202 mL
    50 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.2032 mL 1.504 mL
    100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6016 mL 0.752 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Pterisolic acid A; Pterisolic acid A CFN97975 1401419-85-9 C20H26O5 = 346.4 5mg QQ客服：215959384
    Pterisolic acid B; Pterisolic acid B CFN97976 1401419-86-0 C20H26O4 = 330.4 5mg QQ客服：215959384
    ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid; ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid CFN89078 57719-81-0 C20H28O4 = 332.44 5mg QQ客服：1457312923
    Paniculoside III; Paniculoside III CFN89216 60129-65-9 C26H38O9 = 494.58 5mg QQ客服：2056216494
    (3alpha,4beta,15alpha)-贝壳杉-16-烯-3,15,18-三醇; ent-16-Kaurene-3beta,15beta,18-triol CFN96331 921211-29-2 C20H32O3 = 320.5 5mg QQ客服：1413575084
    15Alpha-羟基贝壳杉-16-烯-19-酸; Grandifloric acid CFN97780 22338-69-8 C20H30O3 = 318.46 5mg QQ客服：3257982914
    Deacetylxylopic acid; Deacetylxylopic acid CFN97131 6619-95-0 C20H30O3 = 318.5 5mg QQ客服：3257982914
    11,15-二羟基-16-贝壳杉烯-19-酸; 11,15-Dihydroxy-16-kauren-19-oic acid CFN98977 57719-76-3 C20H30O4 = 334.5 5mg QQ客服：215959384
    对映-9-羟基-15-氧代-16-贝壳杉烯-19-酸; ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid CFN97261 77658-39-0 C20H28O4 = 332.4 5mg QQ客服：3257982914
    对映-6,9-二羟基-15-氧代-16-贝壳杉烯-19-酸; ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid CFN97294 81264-00-8 C20H28O5 = 348.4 5mg QQ客服：1413575084

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