蓬莪术环氧酮
Zederone
|
|
产品编号 |
CFN92616 |
| CAS编号 |
7727-79-9 |
| 分子式 = 分子量 |
C15H18O3 = 246.3 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Sesquiterpenoids |
| 植物来源 |
The rhizomes of Curcuma zedoaria |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 蓬莪术环氧酮 |
CFN92616 |
7727-79-9 |
10mg |
QQ客服：215959384 |
| 蓬莪术环氧酮 |
CFN92616 |
7727-79-9 |
20mg |
QQ客服：215959384 |
| 蓬莪术环氧酮 |
CFN92616 |
7727-79-9 |
50mg |
QQ客服：215959384 |
| 蓬莪术环氧酮 |
CFN92616 |
7727-79-9 |
100mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Centralised Purchases Unit (CPU), B.I.T.S (India)
University of Hull (United Kingdom)
Universiti Malaysia Pahang (Malaysia)
Chinese University of Hong Kong (China)
Korea Intitute of Science and Technology (KIST) (Korea)
John Innes Centre (United Kingdom)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
University of Malaya (Malaysia)
Universitas Airlangga (Indonesia)
Universidad de Buenos Aires (Argentina)
Florida International University (USA)
Technical University of Denmark (Denmark)
Srinakharinwirot University (Thailand)
Cancer Research Initatives Foundation(CARIF) (Malaysia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries. |
| Targets: |
TNF-α | Nrf2 | NADPH-oxidase | P450 (e.g. CYP17) | Antifection |
| In vivo: |
| Int J Toxicol. 2013 Nov-Dec;32(6):454-62. | | Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice.[Pubmed: 24082031] | The present study aimed to investigate the hepatotoxicity of Zederone isolated from Curcuma elata in mice.
METHODS AND RESULTS:
Adult male mice were intraperitoneally injected with a single dose of Zederone (50-300 mg/kg body weight [BW]). Twenty-four hours after the injection, Zederone induced liver enlargement with scattered white foci over the organ. The medium lethal dose (LD₅₀) value at 24 hours of Zederone was approximately 223 mg/kg BW. Hepatic centrilobular necrosis with marked increases in plasma alanine transaminase activity and total bilirubin levels was observed. Zederone at a dose of 200 mg/kg BW markedly decreased the activity of superoxide dismutase and the hepatic glutathione content, whereas the activity of catalase was not altered. The compound at this dose also increased the messenger RNA (mRNA) expression of Cyp2b10 and Cyp3a11, which are the main drug-metabolizing enzymes in the liver. The mRNA expression of proinflammatory cytokine tumor necrosis factor α was increased. The nuclear factor-E2-related factor 2 protein, which is the transcription factor regulating the antioxidant gene expression, was decreased.
CONCLUSIONS:
The histopathology of massive hepatic centrilobular necrosis with an increase in the expression of cytochrome P450 (Cyp) suggests that the possible potentiation of Zederone-induced hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.0601 mL |
20.3004 mL |
40.6009 mL |
81.2018 mL |
101.5022 mL |
| 5 mM |
0.812 mL |
4.0601 mL |
8.1202 mL |
16.2404 mL |
20.3004 mL |
| 10 mM |
0.406 mL |
2.03 mL |
4.0601 mL |
8.1202 mL |
10.1502 mL |
| 50 mM |
0.0812 mL |
0.406 mL |
0.812 mL |
1.624 mL |
2.03 mL |
| 100 mM |
0.0406 mL |
0.203 mL |
0.406 mL |
0.812 mL |
1.015 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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