醉茄内酯 A

Withanolide A

	产品编号	CFN91964
	CAS编号	32911-62-9
	分子式 = 分子量	C₂₈H₃₈O₆ = 470.60
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The herbs of Physali alkekengi
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产品名称	产品编号	CAS编号	包装	QQ客服
醉茄内酯 A	CFN91964	32911-62-9	1mg	QQ客服：1457312923
醉茄内酯 A	CFN91964	32911-62-9	5mg	QQ客服：1457312923
醉茄内酯 A	CFN91964	32911-62-9	10mg	QQ客服：1457312923
醉茄内酯 A	CFN91964	32911-62-9	20mg	QQ客服：1457312923

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Description:

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. Withanolide A may serve as potential neuroprotective agent due to inhibition of MAPK family proteins and activation of PI3K/Akt signaling, it plays an important role in central muscarinic receptor functional balance and activation of antioxidant system in the cerebral cortex of temporal lobe epileptic condition. Withanolide A shows anticancer activity against the SK-Br-3 cells.

Targets:

In vitro:

Drug Des Devel Ther. 2017 Jun 22;11:1859-1870.

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer.[Pubmed: 28694686 ]

Withanolides are a group of pharmacologically active compounds present in most prodigal amounts in roots and leaves of Withania somnifera (Indian ginseng), one of the most important medicinal plants of Indian traditional practice of medicine. Withanolides are steroidal lactones (highly oxygenated C-28 phytochemicals) and have been reported to exhibit immunomodulatory, anticancer and other activities.
METHODS AND RESULTS:
In the present study, a quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID_73621, CID_435144, CID_301751 and CID_3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID_10413139, CID_11294368, CID_53477765, CID_135887, CID_301751 and CID_3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin.
CONCLUSIONS:
Molecular docking was performed to study the binding conformations and different bonding behaviors, in order to reveal the plausible mechanism of action behind higher accumulation of active Withanolide Analogs with β-tubulin. The results of the present study may help in the designing of lead compound with improved activity.

Mol Neurobiol. 2018 Apr;55(4):2725-2739.

Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway.[Pubmed: 28447311 ]

Glutamate-induced excitotoxicity is one of the major underlying mechanisms for neurodegenerative diseases. Efforts are being made to treat such conditions with an array of natural compounds that can modulate the release of glutamate or the underlying mechanisms associated with it. Withania somnifera extract has potent pharmacologic activity similar to that of Korean Ginseng tea and is used to treat several neuronal disorders. However, to date, little efforts have been made to evaluate individual constituents of this plant for neurodegenerative disorders.
METHODS AND RESULTS:
Present study was carried out to investigate withanolide A, one of the active constituents of Withania somnifera against glutamate-induced excitotoxicity in retinoic acid differentiated Neuro2a neuroblastoma cells. The results indicated that glutamate treatment for 2 h induced death in cells that was significantly attenuated by pre-treatment with MK-801 (specific NMDA receptor antagonist) and different concentrations of withanolide A. Withanolide A abated the glutamate-induced influx of intracellular calcium and excessive ROS production significantly. Further on, glutamate treatment resulted in increased levels of pro-apoptotic and decreased levels of anti-apoptotic proteins, and these protein levels were normalized by various doses of withanolide A.
CONCLUSIONS:
All of these protective effects were partly due to inhibition of MAPK family proteins and activation of PI3K/Akt signaling. Thus, our results suggest that withanolide A may serve as potential neuroprotective agent.

In vivo:

Biochem Cell Biol. 2017 Dec 7.

Altered muscarinic receptor expression in the cerebral cortex of epileptic rats: Restorative role of Withania somnifera.[Pubmed: 29216436]

Temporal Lobe Epilepsy involves a sequence of events which can lead to neurotransmitter signalling alterations. Many herbal extracts are considered as alternative therapeutic method for epilepsy management. In the present study, we investigated the effect of Withania somnifera (WS) root extract and Withanolide A (WA) in the management of Temporal Lobe Epilepsy.
METHODS AND RESULTS:
Confocal imaging of TOPRO-3 stained cortical sections showed severe damage in epileptic brain. We also observed a reduced antioxidant potential and increased peroxide level in epileptic group. Oxidative stress resulted in the down regulation of CREB, NF-κB and TNF-α with an up regulation of the apoptotic factors Caspase 8, 3 and bax in epileptic group. Epileptic condition also resulted in an increased muscarinic receptor binding and mRNA expression in the cerebral cortex. Withania somnifera and Withanolide A significantly reversed the altered muscarinic receptor expression and reversed the oxidative stress and resultant derailment in cell signalling.
CONCLUSIONS:
Thus our studies suggest that Withania somnifera and Withanolide A play an important role in central muscarinic receptor functional balance and activation of antioxidant system in the cerebral cortex of temporal lobe epileptic condition. These findings can be of immense therapeutic significance for epileptic management.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(7Alpha,22R)-7,22,27-三羟基-1-氧代麦角甾烷-2,5,24-三烯-26-酸内酯; Daturataturin A aglycone	CFN97467	904665-71-0	C₂₈H₃₈O₅ = 454.6	5mg	QQ客服：1413575084
Phyperunolide E; Phyperunolide E	CFN96990	1198400-52-0	C₂₈H₄₀O₉ = 520.61	5mg	QQ客服：1457312923
Viscosalactone B; Viscosalactone B	CFN92968	76938-46-0	C₂₈H₄₀O₇ = 488.61	5mg	QQ客服：1413575084
2,3-二氢-3-甲氧基醉茄素A; 2,3-Dihydro-3-methoxywithaferin A	CFN92965	21902-96-5	C₂₉H₄₂O₇ = 502.64	5mg	QQ客服：2159513211
白曼陀罗素; Daturametelin I	CFN97468	904667-65-8	C₃₄H₄₈O₁₀ = 616.8	5mg	QQ客服：3257982914
Daturataturin A; Daturataturin A	CFN99414	133360-51-7	C₃₄H₄₈O₁₀ = 616.8	5mg	QQ客服：1457312923
睡茄灯笼草素C; Withaperuvin C	CFN96433	81644-34-0	C₂₈H₃₈O₇ = 486.59	5mg	QQ客服：1413575084
Physapruin A; Physapruin A	CFN89294	155178-03-3	C₂₈H₃₈O₇ = 486.60	5mg	QQ客服：2056216494
Jaborosalactone D; Jaborosalactone D	CFN92969	19891-82-8	C₂₈H₄₀O₆ = 472.61	5mg	QQ客服：2056216494
醉茄素A; Withaferin A	CFN91895	5119-48-2	C₂₈H₃₈O₆ = 470.60	20mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1249 mL	10.6247 mL	21.2495 mL	42.4989 mL	53.1237 mL
5 mM	0.425 mL	2.1249 mL	4.2499 mL	8.4998 mL	10.6247 mL
10 mM	0.2125 mL	1.0625 mL	2.1249 mL	4.2499 mL	5.3124 mL
50 mM	0.0425 mL	0.2125 mL	0.425 mL	0.85 mL	1.0625 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	0.425 mL	0.5312 mL

醉茄内酯 A

Withanolide A

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