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  • 5,7,4’三羟基-6-异戊烯基异黄酮

    Wighteone

    5,7,4’三羟基-6-异戊烯基异黄酮
    产品编号 CFN98816
    CAS编号 51225-30-0
    分子式 = 分子量 C20H18O5 = 338.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Glycyrrhiza glabra
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5,7,4’三羟基-6-异戊烯基异黄酮 CFN98816 51225-30-0 1mg QQ客服:1457312923
    5,7,4’三羟基-6-异戊烯基异黄酮 CFN98816 51225-30-0 5mg QQ客服:1457312923
    5,7,4’三羟基-6-异戊烯基异黄酮 CFN98816 51225-30-0 10mg QQ客服:1457312923
    5,7,4’三羟基-6-异戊烯基异黄酮 CFN98816 51225-30-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Univerzita Karlova v Praze (Czech Republic)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Illinois (USA)
  • Sapienza University of Rome (Italy)
  • Florida A&M University (USA)
  • Kitasato University (Japan)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Ateneo de Manila University (Philippines)
  • Aarhus University (Denmark)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Uniwersytet Gdański (Poland)
  • Chinese University of Hong Kong (China)
  • Universiti Malaysia Pahang (Malaysia)
  • Utah State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • QASCF2022, 14(4).
  • Antibiotics.2022, 11(4), 510.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Phytomedicine.2018, 38:45-56
  • Anticancer Res.2018, 38(4):2127-2135
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • J Neuroinflammation.2020, 17(1):75.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • J Ginseng Res.2022, 46(1):104-114.
  • Nature Ecology & Evolution2020, doi: 10.1038
  • Medicina (Kaunas).2020, 56(12):685.
  • Anat Rec2018, 24264
  • Curr Issues Mol Biol.2023, 45(3):2136-2156.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Chemistry of Natural Compounds2020, 56,423-426
  • Oncotarget.2017, 8(53):90925-90947
  • Sci Rep.2023, 13(1):14594.
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • The University of Manitoba2021, 35690.
  • Journal of Functional Foods2017, 30:30-38
  • Nutrients.2019, 11(6):E1380
  • VNU Journal of Science2023, 39(2):24-33.
  • Life (Basel).2022, 12(10):1630.
  • ...
  • 生物活性
    Description: Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-60 cancer cell lines, it can effectively inhibit the proliferation of HER2-positive cancer cell lines, and this is considered to be the result of downregulating HSP90 receptor and downstream signaling.
    Targets: HSP (e.g. HSP90) | Antifection
    In vitro:
    Biotechnol Lett. 2006 Jan;28(2):99-105.
    Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent.[Pubmed: 16369693]
    The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs.
    METHODS AND RESULTS:
    The antifungal activity of the natural products of a series of plants was evaluated and wighteone, 5, 7, 4'-trihydroxy-6-(gamma,gamma-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 microg/ml).
    METHODS AND RESULTS:
    Transcriptome profiling of wighteone-treated S. cerevisiae indicated that wighteone is different from commonly used antifungal compounds in its mode of action.
    Phytochemistry. 2001 Dec;58(7):1113-20.
    Cytotoxic isoflavones from Erythrina indica.[Pubmed: 11730876]

    METHODS AND RESULTS:
    Bioassay-directed fractionation of the CH(2)Cl(2)-MeOH (1:1) extract of the stem bark of Erythrina indica, has resulted in the isolation of two new isoflavone derivatives named indicanines D and E together with 11 known compounds including: six isoflavones (genistein, Wighteone, alpinumisoflavone, dimethylalpinumisoflavone, 8-prenyl erythrinin C, and erysenegalensein E), one cinnamate (erythrinassinate B), two pentacyclic triterpenes (oleanolic acid and erythrodiol), and two phytosterols (stigmasterol and its 3-O-beta-D-glucopyranoside).
    CONCLUSIONS:
    The structures of the new compounds were elucidated by means of spectroscopic analysis. The in vitro cytocidal activity against KB cells of some of the isolated compounds is also reported.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL 59.1017 mL 73.8771 mL
    5 mM 0.591 mL 2.9551 mL 5.9102 mL 11.8203 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
    50 mM 0.0591 mL 0.2955 mL 0.591 mL 1.182 mL 1.4775 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7,4’三羟基-6-异戊烯基异黄酮; Wighteone CFN98816 51225-30-0 C20H18O5 = 338.4 5mg QQ客服:3257982914
    Erysubin A; Erysubin A CFN98097 221150-18-1 C20H16O6 = 352.3 5mg QQ客服:3257982914
    刺桐素 C; Erythrinin C CFN97096 63807-85-2 C20H18O6 = 354.4 5mg QQ客服:2159513211
    1''-Hydroxyerythrinin C; 1''-Hydroxyerythrinin C CFN96168 913690-46-7 C20H18O7 = 370.4 5mg QQ客服:2159513211
    1''-Methoxyerythrinin C; 1''-Methoxyerythrinin C CFN96058 221002-11-5 C21H20O7 = 384.4 5mg QQ客服:2056216494
    alpha-3'-二甲基烯丙基染料木黄酮; alpha-Isowighteone CFN97117 65388-03-6 C20H18O5 = 338.4 5mg QQ客服:1413575084
    Furowanin A; Furowanin A CFN97918 911004-72-3 C25H26O7 = 438.5 5mg QQ客服:1413575084
    昆明鸡血藤素; Auriculasin CFN96062 60297-37-2 C25H24O6 = 420.5 5mg QQ客服:3257982914
    橙桑黄酮; Pomiferin CFN93047 572-03-2 C25H24O6 = 420.46 5mg QQ客服:2159513211
    羽扇豆异黄酮; Luteone CFN98655 41743-56-0 C20H18O6 = 354.4 5mg QQ客服:215959384

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