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  • 南藤素

    • 南藤素

    Wallichinine

    南藤素
    		产品编号 CFN96307
    CAS编号 125292-97-9
    分子式 = 分子量 C22H26O5 = 370.5
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Lignans
    植物来源 The stems of Piper wightii.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    南藤素 CFN96307 125292-97-9 1mg QQ客服：1457312923
    南藤素 CFN96307 125292-97-9 5mg QQ客服：1457312923
    南藤素 CFN96307 125292-97-9 10mg QQ客服：1457312923
    南藤素 CFN96307 125292-97-9 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Institute of Chinese Materia Medica (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2024, 29(5):1048.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Front Microbiol.2020, 11:583594.
  • Planta Med.2018, 84(15):1101-1109
  • Front Pharmacol.2021, 12:652860.
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Earth Environ. Sci. 2021, 905:012080.
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Sci Rep. 2017, 8207(7)
  • Reprod Sci.2022,10.1007/s43032-022-01117-4.
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Drug Invention Today2019, 12(6):1303-1306
  • Chin Med.2022, 17(1):66.
  • Molecules.2019, 24(2):329
  • Plos One.2020, 10.1371
  • Food Chem.2017, 221:1135-1144
  • Food Sci Nutr.2019, 8(1):246-256
  • Res Rep Urol.2022, 14:313-326.
  • Heliyon.2023, e12684.
  • Molecules.2019, 24(2):E343
  • Biomolecules.2020, 10(2):E184
  • Applied Biological Chemistry2023, 66:85.
  • Nutrients.2019, 12(1)
  • ...
    • 生物活性
    Description: Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR).
    Targets: PAFR | ABCB1 | ATPase
    In vitro:
    Yao Xue Xue Bao. 1989;24(6):438-43.
    The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim[Pubmed: 2609983]
    Platelet activating factor (PAF) is a highly potent endogenous phospholipid mediator, involved in various inflammatory and cardiovascular disorders.
    METHODS AND RESULTS:
    As part of a research program dealing with PAF inhibitors isolated from Piper plant species, we have isolated kadsurenone (I), denudatin B (II), and N-isobutyl-deca-trans-2-trans-4-dienamide (III) from Piped wallichii (Miq.) Hand-Mazz. and P. hancei Maxim. In a continuing search for potential PAF inhibitor from plants, using PAF induced platelet aggregation as a guide, a new neolignan named hancinone D (IV) was isolated from P. hancei maxim. By X-ray analysis it was identified as a racemate. The X-ray analysis led to a revision of the previously made structure assignment of hancinone C. Another new neolignan named Wallichinine (V), which was identified as an analogue of (IV), along with the known compounds hancinone C (VI), galgravin (VII), dihydropiperlonguminine (VIII) and crotepoxide (IX) were isolated from P. wallichii (Miq.) Hand-Mazz. The structure determination was based upon spectroscopic analysis.
    CONCLUSIONS:
    All of the compounds were for the first time obtained from both plants. In the test of platelet aggregation caused by PAF, I, II, V, VI, VII showed inhibitory activity, whereas III, IV, VII, IX showed no activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6991 mL 13.4953 mL 26.9906 mL 53.9811 mL 67.4764 mL
    5 mM 0.5398 mL 2.6991 mL 5.3981 mL 10.7962 mL 13.4953 mL
    10 mM 0.2699 mL 1.3495 mL 2.6991 mL 5.3981 mL 6.7476 mL
    50 mM 0.054 mL 0.2699 mL 0.5398 mL 1.0796 mL 1.3495 mL
    100 mM 0.027 mL 0.135 mL 0.2699 mL 0.5398 mL 0.6748 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan; 1,6-Dihydro-4,7'-epoxy-1-methoxy-3',4'-methylenedioxy-6-oxo-3,8'-lignan CFN96289 67920-48-3 C20H20O5 = 340.4 5mg QQ客服：215959384
    (2S,3S,5S)-2-(1,3-苯并二氧戊环-5-基)-3,5-二氢-5-甲氧基-3-甲基-5-(2-丙烯-1-基)-6(2H)-苯并呋喃酮; (2S)-2alpha-(1,3-Benzodioxol-5-yl)-3,5-dihydro-5alpha-methoxy-3beta-methyl-5-allyl-2H-benzofuran-6-one CFN96311 57430-03-2 C20H20O5 = 340.4 5mg QQ客服：2159513211
    南五味子素A; Kadsurin A CFN96250 99340-07-5 C21H24O6 = 372.4 5mg QQ客服：1413575084
    胡椒烯酮; Piperenone CFN96283 57625-31-7 C22H28O6 = 388.5 5mg QQ客服：1413575084
    Mirandin B; Mirandin B CFN96286 62163-24-0 C22H26O6 = 386.4 5mg QQ客服：215959384
    布尔乞灵; Burchellin CFN96386 38276-59-4 C20H20O5 = 340.4 5mg QQ客服：3257982914
    3a-表布尔乞灵; 3a-Epiburchellin CFN96709 155551-61-4 C20H20O5 = 340.37 5mg QQ客服：2056216494
    2-表-3a-表布尔乞灵; 2-Epi-3a-epiburchellin CFN96707 57457-99-5 C20H20O5 = 340.37 5mg QQ客服：3257982914
    异风藤奎醇A; Isofutoquinol A CFN91836 62499-70-1 C21H22O5 = 354.4 5mg QQ客服：3257982914
    山酮 C; Hancinone C CFN97876 111843-10-8 C23H28O6 = 400.5 5mg QQ客服：1457312923

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