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  • 牡荆素7-O-葡萄糖苷

    • 牡荆素7-O-葡萄糖苷

    Vitexin 7-glucoside

    牡荆素7-O-葡萄糖苷
    		产品编号 CFN70343
    CAS编号 35109-95-6
    分子式 = 分子量 C27H30O15 = 594.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Crataegus pinnatifida Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 1mg QQ客服：2056216494
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 5mg QQ客服：2056216494
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 10mg QQ客服：2056216494
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 20mg QQ客服：2056216494
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    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Universidad Miguel Hernández (Spain)
  • Institute of Chinese Materia Medica (China)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Julius Kühn-Institut (Germany)
  • Weizmann Institute of Science (Israel)
  • University of Liège (Belgium)
  • Seoul National University (Korea)
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  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Cincinnati (USA)
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  • Shanghai University of TCM (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Essential Oil Research2019, 1677272
  • Journal of Chromatography A2020, 460942
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • Molecules.2022, 27(7):2116.
  • Cells.2023, 12(3):395.
  • Foods.2023, 12(2):318.
  • J Agric Food Chem.2017, 65(13):2670-2676
  • OENO One2023, 57:3.
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Journal of Pharmaceutical Investigation2024, 024-00662-1.
  • Front Pharmacol.2018, 9:236
  • J Nat Sc Biol Med2019, 10(2):149-156
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • J Applied Biological Chemistry2021, 64(2):185-192
  • RSC Advances2017, 86
  • Nat Prod Sci.2018, 24(3):206
  • Molecules.2019, 24(2):329
  • Planta Med.2019, 85(3):217-224
  • JEJU National University2022, 10478.
  • J Cell Mol Med.2023, jcmm.17968.
  • Phytochem Anal.2022, doi: 10.1002
  • Front Chem.2022, 10:1048467.
  • ...
    • 生物活性
    Description: Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
    In vitro:
    European Journal of Medicinal Chemistry, 2006, 41(5):605-610.
    Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink]
    A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
    METHODS AND RESULTS:
    In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
    CONCLUSIONS:
    This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6821 mL 8.4104 mL 16.8209 mL 33.6417 mL 42.0521 mL
    5 mM 0.3364 mL 1.6821 mL 3.3642 mL 6.7283 mL 8.4104 mL
    10 mM 0.1682 mL 0.841 mL 1.6821 mL 3.3642 mL 4.2052 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    O-去甲基荷叶碱 ; O-Nornuciferine CFN96770 3153-55-7 C18H19NO2 = 281.35 5mg QQ客服：1457312923
    慈溪麦冬皂苷A; Cixiophiopogon A CFN90637 288143-27-1 C44H70O18 = 887.02 10mg QQ客服：215959384
    7-乙酰基石松胺N-氧化物; 7-O-Acetyllycopsamine N-oxide CFN00464 685132-58-5 C17H27NO7 = 357.4 5mg QQ客服：2056216494
    苦瓜二醇A; Charantadiol A CFN92572 1220890-23-2 C30H46O3 = 454.7 5mg QQ客服：3257982914

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