牡荆素7-O-葡萄糖苷
Vitexin 7-glucoside
|
产品编号 |
CFN70343 |
CAS编号 |
35109-95-6 |
分子式 = 分子量 |
C27H30O15 = 594.5 |
产品纯度 |
>=98% |
物理属性 |
Powder |
化合物类型 |
Flavonoids |
植物来源 |
The fruits of Crataegus pinnatifida Bge. |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
牡荆素7-O-葡萄糖苷 |
CFN70343 |
35109-95-6 |
1mg |
QQ客服:3257982914 |
牡荆素7-O-葡萄糖苷 |
CFN70343 |
35109-95-6 |
5mg |
QQ客服:3257982914 |
牡荆素7-O-葡萄糖苷 |
CFN70343 |
35109-95-6 |
10mg |
QQ客服:3257982914 |
牡荆素7-O-葡萄糖苷 |
CFN70343 |
35109-95-6 |
20mg |
QQ客服:3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
University of Vienna (Austria)
Heidelberg University (Germany)
Ain Shams University (Egypt)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Chinese University of Hong Kong (China)
Universidad Industrial de Santander (Colombia)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
Auburn University (USA)
Funda??o Universitária de Desenvolvimento (Brazil)
University of Fribourg (Switzerland)
Sanford Burnham Medical Research Institute (USA)
Universitas Airlangga (Indonesia)
Charles University in Prague (Czech Republic)
Kyushu University (Japan)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo. |
In vitro: |
European Journal of Medicinal Chemistry, 2006, 41(5):605-610. | Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink] | A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
METHODS AND RESULTS:
In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
CONCLUSIONS:
This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.6821 mL |
8.4104 mL |
16.8209 mL |
33.6417 mL |
42.0521 mL |
5 mM |
0.3364 mL |
1.6821 mL |
3.3642 mL |
6.7283 mL |
8.4104 mL |
10 mM |
0.1682 mL |
0.841 mL |
1.6821 mL |
3.3642 mL |
4.2052 mL |
50 mM |
0.0336 mL |
0.1682 mL |
0.3364 mL |
0.6728 mL |
0.841 mL |
100 mM |
0.0168 mL |
0.0841 mL |
0.1682 mL |
0.3364 mL |
0.4205 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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