牡荆素7-O-葡萄糖苷

Vitexin 7-glucoside

	产品编号	CFN70343
	CAS编号	35109-95-6
	分子式 = 分子量	C₂₇H₃₀O₁₅ = 594.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The fruits of Crataegus pinnatifida Bge.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	1mg	QQ客服：1457312923
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	5mg	QQ客服：1457312923
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	10mg	QQ客服：1457312923
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Chulalongkorn University (Thailand)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

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Description:

Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.

In vitro:

European Journal of Medicinal Chemistry, 2006, 41(5):605-610.

Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink]

A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
METHODS AND RESULTS:
In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
CONCLUSIONS:
This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6821 mL	8.4104 mL	16.8209 mL	33.6417 mL	42.0521 mL
5 mM	0.3364 mL	1.6821 mL	3.3642 mL	6.7283 mL	8.4104 mL
10 mM	0.1682 mL	0.841 mL	1.6821 mL	3.3642 mL	4.2052 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL