牡荆素7-O-葡萄糖苷

Vitexin 7-glucoside

	产品编号	CFN70343
	CAS编号	35109-95-6
	分子式 = 分子量	C₂₇H₃₀O₁₅ = 594.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The fruits of Crataegus pinnatifida Bge.
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产品名称	产品编号	CAS编号	包装	QQ客服
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	1mg	QQ客服：3257982914
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	5mg	QQ客服：3257982914
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	10mg	QQ客服：3257982914
牡荆素7-O-葡萄糖苷	CFN70343	35109-95-6	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Copenhagen University (Denmark)

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Universidad Veracuzana (Mexico)

Universiti Kebangsaan Malaysia (Malaysia)

University of Stirling (United Kingdom)

S.N.D.T. Women's University (India)

Cornell University (USA)

Auburn University (USA)

University of Virginia (USA)

Nicolaus Copernicus Uniwersity (Poland)

Julius Kühn-Institut (Germany)

University of Sao Paulo (Brazil)

Universidade Católica Portuguesa (Portugal)

University of Perugia (Italy)

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Description:

Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.

In vitro:

European Journal of Medicinal Chemistry, 2006, 41(5):605-610.

Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink]

A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
METHODS AND RESULTS:
In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
CONCLUSIONS:
This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Isomargaritene; Isomargaritene	CFN95304	64271-11-0	C₂₈H₃₂O₁₄ = 592.6	10mg	QQ客服：1413575084
6''-O-乙酰基异牡荆黄素; 6''-O-acetylisovitexin	CFN99341	1223097-20-8	C₂₃H₂₂O₁₁ = 474.4	5mg	QQ客服：215959384
Meloside A; Meloside A	CFN90132	60767-80-8	C₂₇H₃₀O₁₅ = 594.52	5mg	QQ客服：3257982914
异肥皂草苷; Isosaponarin	CFN90133	19416-87-6	C₂₇H₃₀O₁₅ = 594.52	10mg	QQ客服：2159513211
王不留行黄酮苷; Vaccarin	CFN90131	53452-16-7	C₃₂H₃₈O₁₉ = 726.64	20mg	QQ客服：1413575084
异肥皂草苷 2''-O-葡萄糖苷; Isosaponarin 2''-O-glucoside (Isovitexin-2''-4'-di-O-beta-D-glucoside)	CFN95296	63316-27-8	C₃₃H₄₀O₂₀ = 756.7	10mg	QQ客服：3257982914
王不留行黄酮苷E; Vaccarin E	CFN95252	2252345-81-4	C₄₂H₄₈O₂₂ = 904.8	10mg	QQ客服：2159513211
皂草苷；皂草黄苷; Saponarin	CFN90134	20310-89-8	C₂₇H₃₀O₁₅ = 594.52	10mg	QQ客服：1457312923
当药黄素; Swertisin	CFN90621	6991-10-2	C₂₂H₂₂O₁₀ = 446.4	10mg	QQ客服：2159513211
斯皮诺素; Spinosin	CFN99600	72063-39-9	C₂₈H₃₂O₁₅ = 608.55	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6821 mL	8.4104 mL	16.8209 mL	33.6417 mL	42.0521 mL
5 mM	0.3364 mL	1.6821 mL	3.3642 mL	6.7283 mL	8.4104 mL
10 mM	0.1682 mL	0.841 mL	1.6821 mL	3.3642 mL	4.2052 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL