葡萄素

Viniferin

	产品编号	CFN92854
	CAS编号	253435-07-3
	分子式 = 分子量	C₂₈H₂₂O₆ = 454.1
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Gnetum montanum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
葡萄素	CFN92854	253435-07-3	1mg	QQ客服：2056216494
葡萄素	CFN92854	253435-07-3	5mg	QQ客服：2056216494
葡萄素	CFN92854	253435-07-3	10mg	QQ客服：2056216494
葡萄素	CFN92854	253435-07-3	20mg	QQ客服：2056216494

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Mendel University in Brno (Czech Republic)

Sanford Burnham Medical Research Institute (USA)

Uniwersytet Jagielloński w Krakowie (Poland)

University of Canterbury (New Zealand)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Medical University of Gdansk (Poland)

Mahatma Gandhi University (India)

University of Hull (United Kingdom)

Stanford University (USA)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

Instituto Politécnico de Bragan?a (Portugal)

Georgia Institute of Technology (USA)

More...

Description:

α-Viniferin has anti-oxidant and anticancer activities, it strongly inhibits the activities of the two CYPs dose dependently. α-Viniferin suppresses the expression of proinflammatory genes iNOS and COX-2 in the early stage of inflammation by inhibiting the Akt/PI3K-dependent NF-κB activation and inhibits the production of proinflammatory mediators NO and PGE2 in the late stage by stimulating Nrf2-mediated HO-1 signaling pathway in LPS-stimulated BV2 microglial cells. ɛ-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis.

Targets:

NO | PGE | NOS | COX | NF-kB | PI3K | Akt | Nrf2 | HO-1 | P450 (e.g. CYP17)

In vitro:

OMICS. 2014 May;18(5):324-34.

Towards novel anti-tumor strategies for hepatic cancer: ɛ-viniferin in combination with vincristine displays pharmacodynamic synergy at lower doses in HepG2 cells.[Pubmed: 24341688]

We investigated the anti-tumor effect of ɛ-Viniferin alone, and the putative synergy of ɛ-Viniferin with vincristine on the growth of HepG2 cells in vitro.
METHODS AND RESULTS:
Growth inhibition and apoptosis induction were determined by MTT assay and annexin V/propidium iodide (PI), respectively. Morphological changes and DNA fragmentation were investigated under electron microscopy and by agarose gel electrophoresis, respectively. The results collectively showed that treating cells with ɛ-Viniferin and vincristine significantly inhibited cell viability at lower doses as compared to each agent applied alone. IC(50) values for ɛ-Viniferin and vincristine were determined as 98.3 and 52.5 μM at 24 h, respectively. IC(50) value of ɛ-Viniferin in combination with vincristine was 15.8+11.25 μM (mean/SD) at 24 h. The viability of cells treated with 17.9 μM vincristine alone for 24 h was 79.62%; it reduced to 26.53% when 25 μM ɛ-Viniferin was added in combination with vincristine (p<0.05). We found that combination of drugs promoted the sensitivity of cells against to vincristine treatment.
CONCLUSIONS:
This study thus suggests that low concentrations of ɛ-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis.

Nat Prod Commun. 2015 Jun;10(6):1017-8.

Synthesis of ε-Viniferin Glycosides by Glucosyltransferase from Phytolacca americana and their Inhibitory Activity on Histamine Release from Rat Peritoneal Mast Cells.[Pubmed: 26197540]

METHODS AND RESULTS:
Glycosylation of (+)-ε-viniferin was investigated using glucosyltransferase from Phytolacca americana (PaGT3) as a biocatalyst. (+)-ε-Viniferin was converted by PaGT3 into its 4b- and 13b-β-D-glucosides, the inhibitory activities on histamine release from rat peritoneal mast cells of which were higher than that of (+)-ε-viniferin.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Pallidol; Pallidol	CFN92341	105037-88-5	C₂₈H₂₂O₆ = 454.5	10mg	QQ客服：1413575084
Gnetulin; Gnetulin	CFN92444	152340-24-4	C₃₀H₂₆O₈ = 514.5	5mg	QQ客服：1413575084
Leachianol G; Leachianol G	CFN95146	164204-62-0	C₂₈H₂₄O₇ = 472.5	5mg	QQ客服：1457312923
Leachianol F; Leachianol F	CFN95147	164123-50-6	C₂₈H₂₄O₇ = 472.5	5mg	QQ客服：2056216494
蛇葡萄素F; Ampelopsin F	CFN92340	151487-08-0	C₂₈H₂₂O₆ = 454.5	5mg	QQ客服：3257982914
Ampelopsin G; Ampelopsin G	CFN95148	151487-09-1	C₄₂H₃₂O₉ = 680.7	5mg	QQ客服：1457312923
白桑八醇; Alboctalol	CFN97075	62394-00-7	C₂₈H₂₄O₈ = 488.5	5mg	QQ客服：215959384
cis-epsilon-葡萄素; cis-epsilon-Viniferin	CFN95781	62250-12-8	C₂₈H₂₂O₆ = 454.5	5mg	QQ客服：2056216494
葡萄素; Viniferin	CFN92854	253435-07-3	C₂₈H₂₂O₆ = 454.1	5mg	QQ客服：215959384
买麻藤素D; Gnetin D	CFN92423	84870-53-1	C₂₈H₂₂O₇ = 470.5	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2022 mL	11.0108 mL	22.0216 mL	44.0432 mL	55.054 mL
5 mM	0.4404 mL	2.2022 mL	4.4043 mL	8.8086 mL	11.0108 mL
10 mM	0.2202 mL	1.1011 mL	2.2022 mL	4.4043 mL	5.5054 mL
50 mM	0.044 mL	0.2202 mL	0.4404 mL	0.8809 mL	1.1011 mL
100 mM	0.022 mL	0.1101 mL	0.2202 mL	0.4404 mL	0.5505 mL

葡萄素

Viniferin

信息支持

联系方式