葡萄素

Viniferin

	产品编号	CFN92854
	CAS编号	253435-07-3
	分子式 = 分子量	C₂₈H₂₂O₆ = 454.1
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Gnetum montanum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
葡萄素	CFN92854	253435-07-3	1mg	QQ客服：1413575084
葡萄素	CFN92854	253435-07-3	5mg	QQ客服：1413575084
葡萄素	CFN92854	253435-07-3	10mg	QQ客服：1413575084
葡萄素	CFN92854	253435-07-3	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade Federal de Goias (UFG) (Brazil)

University of Hawaii Cancer Center (USA)

Monash University Malaysia (Malaysia)

Weizmann Institute of Science (Israel)

Shanghai Institute of Biochemistry and Cell Biology (China)

University of Indonesia (Indonesia)

Johannes Gutenberg University Mainz (JGU) (Germany)

University of Hull (United Kingdom)

Research Unit Molecular Epigenetics (MEG) (Germany)

Monash University (Australia)

Korea Intitute of Science and Technology (KIST) (Korea)

Universidade do Porto (Portugal)

Nanjing University of Chinese Medicine (China)

Medical University of South Carolina (USA)

More...

Description:

α-Viniferin has anti-oxidant and anticancer activities, it strongly inhibits the activities of the two CYPs dose dependently. α-Viniferin suppresses the expression of proinflammatory genes iNOS and COX-2 in the early stage of inflammation by inhibiting the Akt/PI3K-dependent NF-κB activation and inhibits the production of proinflammatory mediators NO and PGE2 in the late stage by stimulating Nrf2-mediated HO-1 signaling pathway in LPS-stimulated BV2 microglial cells. ɛ-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis.

Targets:

NO | PGE | NOS | COX | NF-kB | PI3K | Akt | Nrf2 | HO-1 | P450 (e.g. CYP17)

In vitro:

OMICS. 2014 May;18(5):324-34.

Towards novel anti-tumor strategies for hepatic cancer: ɛ-viniferin in combination with vincristine displays pharmacodynamic synergy at lower doses in HepG2 cells.[Pubmed: 24341688]

We investigated the anti-tumor effect of ɛ-Viniferin alone, and the putative synergy of ɛ-Viniferin with vincristine on the growth of HepG2 cells in vitro.
METHODS AND RESULTS:
Growth inhibition and apoptosis induction were determined by MTT assay and annexin V/propidium iodide (PI), respectively. Morphological changes and DNA fragmentation were investigated under electron microscopy and by agarose gel electrophoresis, respectively. The results collectively showed that treating cells with ɛ-Viniferin and vincristine significantly inhibited cell viability at lower doses as compared to each agent applied alone. IC(50) values for ɛ-Viniferin and vincristine were determined as 98.3 and 52.5 μM at 24 h, respectively. IC(50) value of ɛ-Viniferin in combination with vincristine was 15.8+11.25 μM (mean/SD) at 24 h. The viability of cells treated with 17.9 μM vincristine alone for 24 h was 79.62%; it reduced to 26.53% when 25 μM ɛ-Viniferin was added in combination with vincristine (p<0.05). We found that combination of drugs promoted the sensitivity of cells against to vincristine treatment.
CONCLUSIONS:
This study thus suggests that low concentrations of ɛ-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis.

Nat Prod Commun. 2015 Jun;10(6):1017-8.

Synthesis of ε-Viniferin Glycosides by Glucosyltransferase from Phytolacca americana and their Inhibitory Activity on Histamine Release from Rat Peritoneal Mast Cells.[Pubmed: 26197540]

METHODS AND RESULTS:
Glycosylation of (+)-ε-viniferin was investigated using glucosyltransferase from Phytolacca americana (PaGT3) as a biocatalyst. (+)-ε-Viniferin was converted by PaGT3 into its 4b- and 13b-β-D-glucosides, the inhibitory activities on histamine release from rat peritoneal mast cells of which were higher than that of (+)-ε-viniferin.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
射干素B; Shegansu B	CFN92424	291535-65-4	C₃₀H₂₆O₈ = 514.5	5mg	QQ客服：3257982914
双异丹叶大黄素A; Bisisorhapontigenin A	CFN92592	865474-98-2	C₃₁H₂₈O₈ = 528.6	5mg	QQ客服：1457312923
Pallidol; Pallidol	CFN92341	105037-88-5	C₂₈H₂₂O₆ = 454.5	10mg	QQ客服：2056216494
Gnetulin; Gnetulin	CFN92444	152340-24-4	C₃₀H₂₆O₈ = 514.5	5mg	QQ客服：2159513211
Leachianol G; Leachianol G	CFN95146	164204-62-0	C₂₈H₂₄O₇ = 472.5	5mg	QQ客服：2056216494
Leachianol F; Leachianol F	CFN95147	164123-50-6	C₂₈H₂₄O₇ = 472.5	5mg	QQ客服：2159513211
蛇葡萄素F; Ampelopsin F	CFN92340	151487-08-0	C₂₈H₂₂O₆ = 454.5	5mg	QQ客服：3257982914
Ampelopsin G; Ampelopsin G	CFN95148	151487-09-1	C₄₂H₃₂O₉ = 680.7	5mg	QQ客服：2056216494
白桑八醇; Alboctalol	CFN97075	62394-00-7	C₂₈H₂₄O₈ = 488.5	5mg	QQ客服：215959384
cis-epsilon-葡萄素; cis-epsilon-Viniferin	CFN95781	62250-12-8	C₂₈H₂₂O₆ = 454.5	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2022 mL	11.0108 mL	22.0216 mL	44.0432 mL	55.054 mL
5 mM	0.4404 mL	2.2022 mL	4.4043 mL	8.8086 mL	11.0108 mL
10 mM	0.2202 mL	1.1011 mL	2.2022 mL	4.4043 mL	5.5054 mL
50 mM	0.044 mL	0.2202 mL	0.4404 mL	0.8809 mL	1.1011 mL
100 mM	0.022 mL	0.1101 mL	0.2202 mL	0.4404 mL	0.5505 mL

葡萄素

Viniferin

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