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  • 苜蓿素

    Tricin

    苜蓿素
    产品编号 CFN98841
    CAS编号 520-32-1
    分子式 = 分子量 C17H14O7 = 330.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Avena sativa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苜蓿素 CFN98841 520-32-1 1mg QQ客服:3257982914
    苜蓿素 CFN98841 520-32-1 5mg QQ客服:3257982914
    苜蓿素 CFN98841 520-32-1 10mg QQ客服:3257982914
    苜蓿素 CFN98841 520-32-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Ohio State University (USA)
  • University of Oslo (Norway)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Universidade de Franca (Brazil)
  • University of Indonesia (Indonesia)
  • Uniwersytet Gdański (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Charles Sturt University (Denmark)
  • University of Mysore (India)
  • Auburn University (USA)
  • Lund University (Sweden)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Universiti Malaysia Pahang (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Lab Chip.2018, 18(6):971-978
  • Int J Mol Med.2016, 37(2):501-8
  • PLoS One.2018, 13(4):e0195642
  • Aquaculture2019, 510:392-399
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Molecules.2015, 20(11):20014-30
  • Mol Med Rep.2015, 12(5):7789-95
  • J Ethnopharmacol.2017, 196:75-83
  • J Sep Sci.2020, 43(22):4148-4161.
  • Int J Mol Sci.2020, 21(19),7070.
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Front Pharmacol.2019, 10:1226
  • Enzyme and Microbial Technology2022, 110002.
  • Int J Mol Sci.2022, 23(10):5468.
  • Front Pharmacol.2021, 12:607403.
  • Nutrients.2020, 12(12):3638.
  • Pharm Biol.2016, 54(7):1255-62
  • Research Square2020, doi: 10.21203.
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Foods.2022, 11(12):1773.
  • Molecules.2020, 25(18):4283.
  • Saudi Pharm J2020, 10.1016
  • J Nat Prod.2023, 86(2):264-275.
  • ...
  • 生物活性
    Description: Tricin is evaluated as a type of tyrosinase inhibitor, it exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia.Tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication, it may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis.
    Targets: TLR | p38MAPK | JNK | NF-kB | Phospholipase (e.g. PLA) | Tyrosinase | COX | JAK | STAT | HSC
    In vitro:
    Biosci Biotechnol Biochem. 2015 May;79(5):700-6.
    Tricin derivatives as anti-inflammatory and anti-allergic constituents from the aerial part of Zizania latifolia.[Pubmed: 25559019]

    METHODS AND RESULTS:
    Methanol extract of Zizania latifolia was partitioned with EtOAc, n-BuOH, and H2O. From the EtOAc layers, a new flavonolignan along with a known flavone and three known flavonolignans, Tricin (1), salcolin A (2), salcolin B (3), and salcolin C (4), were isolated through repeated silica gel and ODS column chromatography. The chemical structure of the new flavonolignan was determined to be Tricin-4'-O-[erythro-β-guaiacyl-(7″-O-methyl)-glyceryl] ether and was named salcolin D (5) based on physicochemical and spectroscopic data, including FT-NMR and ESI-MS. All compounds were isolated for the first time from this plant. Compounds 2-5, Tricin derivatives, all exhibited higher anti-inflammatory and anti-allergy activities than Tricin. In particular, salcolin D (5) was shown to have the strongest inhibitory activity against LPS-induced NO production in RAW 264.7 cells as well as β-hexosaminidase release in IgE-sensitized RBL-2H3 cells.
    CONCLUSIONS:
    These results suggest that the presence of Tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia.
    Microbes Infect. 2012 Oct;14(12):1086-92.
    Anti-cytomegalovirus effects of tricin are dependent on CXCL11.[Pubmed: 22683667]
    It has been reported that treatment with Tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5.
    METHODS AND RESULTS:
    In this paper, we examined the mechanisms for the anti-HCMV effects of Tricin in MRC-5 cells. Exposure of fibroblasts to Tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells.
    CONCLUSIONS:
    These results suggest that Tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of Tricin.
    J Agric Food Chem . 2018 Jul 5;66(26):6708-6716.
    Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7[Pubmed: 29877083]
    Abstract Tricin, a natural flavonoid present in large amounts in rice bran, was investigated for the mechanisms by which it exhibited antiproliferation and anti-invasion in C6 glioma cells. The results indicated that treatment with 5, 10, 25, and 50 μM tricin for 48 h significantly ( p < 0.05) inhibited cell numbers and colony numbers with values of 134.3 ± 5.5, 114.6 ± 2.5, 106.3 ± 3.2, and 57.3 ± 10.2, respectively. Tricin also inhibited C6-cell motility, migration, and invasion. Tricin changed the cytoskeletal organization, reduced matrix-metalloproteinase (MMP) expression, and upregulated E-cadherin. Tricin decreased FAK protein levels and suppressed focal-adhesion-kinase (FAK)-downstream-signal activation. Most importantly, tricin dose-dependently upregulated microRNA-7 (miR-7). Transfection with an miR-7 inhibitor suppressed miR-7 expression, increased FAK expression, and promoted the proliferation and invasion in C6 cells. The data support a novel anticancer mechanism of tricin that involves upregulation of FAK-targeting miR-7 in C6 glioma cells. Keywords: anticancer; focal-adhesion kinase; glioma; microRNA-7; tricin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1378 mL 30.2755 mL 60.551 mL 75.6888 mL
    5 mM 0.6055 mL 3.0276 mL 6.0551 mL 12.1102 mL 15.1378 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0551 mL 7.5689 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.211 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    粘毛黄芩素II; Viscidulin II CFN92214 92519-93-2 C17H14O7 = 330.3 5mg QQ客服:2159513211
    5,2',6'-三羟基-6,7,8-三甲氧基黄酮; 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone CFN92215 98187-98-5 C18H16O8 = 360.3 5mg QQ客服:215959384
    半枝莲种素; Rivularin CFN92217 70028-59-0 C18H16O7 = 344.3 5mg QQ客服:2056216494
    黄芩黄酮II; Skullcapflavone II CFN92216 55084-08-7 C19H18O8 = 374.4 10mg QQ客服:1413575084
    3',5,5',7-四羟基-4',6-二甲氧基黄酮; 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone CFN99369 125537-92-0 C17H14O8 = 346.3 5mg QQ客服:1457312923
    5,7,3'-三羟基-6,4',5'-三甲氧基黄酮; 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone CFN90939 78417-26-2 C18H16O8 = 360.3 5mg QQ客服:1413575084
    3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone; 3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone CFN95397 29976-51-0 C19H18O7 = 358.4 5mg QQ客服:3257982914
    三粒小麦黄酮; Tricetin CFN70392 520-31-0 C15H10O7 = 302.2 10mg QQ客服:3257982914
    苜蓿素; Tricin CFN98841 520-32-1 C17H14O7 = 330.3 10mg QQ客服:3257982914
    4',5-二羟基-3',5',6,7-四甲氧基黄酮; 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone CFN97322 83133-17-9 C19H18O8 = 374.4 5mg QQ客服:2056216494

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