| In vitro: |
| Planta Med. 1997 Jun;63(3):213-5. | | Antioxidative action of diterpenoids from Podocarpus nagi.[Pubmed: 9225601] |
METHODS AND RESULTS:
Diterpenoids, totarol (1), Totaradiol (2), 19-hydroxytotarol (3), totaral (4), 4 beta-carboxy-19-nortotarol (5), sugiol (6), isolated from Podocarpus nagi, were evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH were inhibited by these terpenoids. They inhibited linoleic acid autoxidation but not generation of superoxide anion. Totarol (1) protected mitochondrial respiratory enzyme activities against NADPH induced oxidative injury.
CONCLUSIONS:
Totarane diterpenes from P. nagi were shown to be effective to protect biological systems and function against various oxidative stresses. | | Nat.Prod.Res.,2006, 20(6): 606-10. | | Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest.[Pubmed: 16835095] |
METHODS AND RESULTS:
Bioassay-directed fractionation of an extract of the root and bark of Podocarpus madagascariensis resulted in the isolation of a new totarol diterpenoid (1) in addition to the three known cytotoxic diterpenoids 19-hydroxytotarol (2), Totaradiol (3), and 4beta-carboxy-19-nor-totarol (4). The structure of the new compound 1 was established as methyl-13-hydroxy-14-isopropyl-9(11),12,14(8)-podocarpatriene-19-oate on the basis of 1D and 2D NMR spectroscopic interpretation and methylation of 4.
CONCLUSIONS:
All the compounds exhibited cytotoxic activity against the A2780 ovarian cancer cell line. |
|
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