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    Topotecan

    拓扑替康
    产品编号 CFN93314
    CAS编号 123948-87-8
    分子式 = 分子量 C23H23N3O5 = 421.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Camptotheca acuminata Decne
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    拓扑替康 CFN93314 123948-87-8 10mg QQ客服:3257982914
    拓扑替康 CFN93314 123948-87-8 20mg QQ客服:3257982914
    拓扑替康 CFN93314 123948-87-8 50mg QQ客服:3257982914
    拓扑替康 CFN93314 123948-87-8 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Putra Malaysia(UPM) (Malaysia)
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  • National Cancer Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Heliyon.2024, 10(7):e28755.
  • Food Chem Toxicol.2023, 176:113785.
  • Oncol Rep.2016, 35(3):1356-64
  • Mie University2019, 10076.
  • J Ethnopharmacol.2017, 198:91-97
  • Pharmacognosy Magazine2017, 13(52):868-874
  • ACS Pharmacol.Transl.Sci.2024, 4c00003.
  • J Ethnopharmacol.2019, 241:112025
  • Food Chem.2022, 373(Pt B):131364.
  • Chem Biol Interact.2019, 298:1-7
  • Molecules.2020 ,25(16):3697.
  • J Sep Sci.2020, 201901140
  • BMC Plant Biol.2021, 21(1):60.
  • FEBS Lett.2015, 589(1):182-7
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Journal of Ginseng Research2023, 12.004.
  • Pharmaceutics.2021, 13(7):1028.
  • Free Radic Biol Med.2021, 166:104-115.
  • Front Pharmacol.2021, 12:607403.
  • Anal Bioanal Chem.2016, 408(1):177-90.
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Molecules.2024, 29(6):1240.
  • Molecules2022, 27(9):2827.
  • ...
  • 生物活性
    Description: TLyp-1-functionalized topotecan-loaded niosomes could significantly improve anti-glioma treatment. Preparation of topotecan into a temperature-sensitive phase-change hydrogel achieves a long-term sustained antitumor effect on Rb cells, and may be a useful strategy for the treatment of intraocular Rb.
    In vitro:
    Onco Targets Ther. 2019 Jul 30;12:6069-6082.
    A temperature-sensitive phase-change hydrogel of topotecan achieves a long-term sustained antitumor effect on retinoblastoma cells.[Pubmed: 31534347 ]
    Retinoblastoma (Rb) is one of the most common malignancies among children. Following early diagnosis and prompt treatment, the clinical outcome or prognosis of Rb is promising. However, the prognosis or survival rates of patients with late-stage Rb remain poor. Current therapeutic strategies for advanced Rb mainly involve the use of advanced chemotherapeutic options. However, the efficacy of these strategies is not satisfactory. Therefore, the development of novel strategies to achieve a more effective antitumor effect on late-stage Rb is of crucial importance.
    METHODS AND RESULTS:
    Topotecan was dissolved in phosphate-buffered saline and prepared into a temperature-sensitive phase-change hydrogel (termed Topo-Gel). Moreover, Topo-Gel was injected into tumor tissues formed by Y79 cells (an Rb cell line) in nude mice to examine the long-term release and long-acting antitumor effect of Topo-Gel on Rb tumors. Topo-Gel transforms from liquid to a hydrogel at near body temperatures (phase-change temperature [T1/2] was 37.23±0.473 °C), and maintains the slow release of topotecan in Rb tumor tissues. Following the subcutaneous injection of Topo-Gel, the treatment induced long-acting inhibition of tumor growth and relieved the adverse effects associated with topotecan. Topo-Gel, a temperature-sensitive phase-change hydrogel, is a slow-release system that prolongs the presence of topotecan in Rb tissues, and preserves the efficacy of topotecan in the long term.
    CONCLUSIONS:
    Preparation of topotecan into a temperature-sensitive phase-change hydrogel achieves a long-term sustained antitumor effect on Rb cells, and may be a useful strategy for the treatment of intraocular Rb.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3728 mL 11.8638 mL 23.7276 mL 47.4552 mL 59.319 mL
    5 mM 0.4746 mL 2.3728 mL 4.7455 mL 9.491 mL 11.8638 mL
    10 mM 0.2373 mL 1.1864 mL 2.3728 mL 4.7455 mL 5.9319 mL
    50 mM 0.0475 mL 0.2373 mL 0.4746 mL 0.9491 mL 1.1864 mL
    100 mM 0.0237 mL 0.1186 mL 0.2373 mL 0.4746 mL 0.5932 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    咖啡酸4-O-葡萄糖苷; Caffeic acid 4-O-glucoside CFN91682 166735-99-5 C15H18O9 = 342.3 10mg QQ客服:2159513211
    磷酸二甲氨乙酯; Demanyl phosphate CFN00071 6909-62-2 C4H12NO4P = 169.12 5mg QQ客服:3257982914
    3,6-双马豆酰基去甲莨菪烷; 3,6-Ditigloyloxynortropane CFN00159 359723-70-9 C17H25NO4 = 307.39 5mg QQ客服:3257982914
    盐酸青藤碱; Sinomenine HCl CFN99561 6080-33-7 C19H23NO4.HCl = 365.85 20mg QQ客服:1457312923

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