生根粉263

Navitoclax (ABT-263)

	产品编号	CFN60060
	CAS编号	923564-51-6
	分子式 = 分子量	C₄₇H₅₅ClF₃N₅O₆S₃ = 974.61
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
生根粉263	CFN60060	923564-51-6	1mg	QQ客服：1457312923
生根粉263	CFN60060	923564-51-6	5mg	QQ客服：1457312923
生根粉263	CFN60060	923564-51-6	10mg	QQ客服：1457312923
生根粉263	CFN60060	923564-51-6	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Leibniz Institute of Plant Biochemistry (Germany)

Washington State University (USA)

University of Dicle (Turkey)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Centrum Menselijke Erfelijkheid (Belgium)

University of British Columbia (Canada)

University of Hertfordshire (United Kingdom)

Rio de Janeiro State University (Brazil)

University of Lodz (Poland)

Nicolaus Copernicus Uniwersity (Poland)

National Cancer Institute (USA)

Imperial College London (United Kingdom)

Chungnam National University (Korea)

University of Maryland School of Medicine (USA)

More...

Description:

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1.

Targets:

Bcl-xL/Bcl-2/Bcl-w

In vitro:

Clin Cancer Res, 2008 Jun 1;14(11):3268-77.

Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models.[Pubmed: 18519752]

The purpose of this study was to characterize the activity of the Bcl-2 protein family inhibitor ABT-263 in a panel of small cell lung cancer (SCLC) xenograft models.
METHODS AND RESULTS:
A panel of 11 SCLC xenograft models was established to evaluate the efficacy of ABT-263. Single agent activity was examined on a continuous dosing schedule in each of these models. The H146 model was used to further evaluate dose and schedule, comparison to standard cytotoxic agents, and induction of apoptosis. ABT-263 exhibited a range of antitumor activity, leading to complete tumor regression in several models. Significant regressions of tumors as large as 1 cc were also observed. The efficacy of ABT-263 was also quite durable; in several cases, minimal tumor regrowth was noted several weeks after the cessation of treatment. Antitumor effects were equal or superior to that of several clinically approved cytotoxic agents. Regression of large established tumors was observed through several cycles of therapy and efficacy was retained in a Pgp-1 overexpressing line. Significant efficacy was observed on several dose and therapeutic schedules and was associated with significant induction of apoptosis.
CONCLUSIONS:
ABT-263 is a potent, orally bioavailable inhibitor of Bcl-2 family proteins that has recently entered clinical trials. The efficacy data reported here suggest that SCLC is a promising area of clinical investigation with this agent.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2,7-二去乙酰氧紫杉宁J; 2,7-Dideacetoxytaxinine J	CFN96979	115810-14-5	C₃₅H₄₄O₈ = 592.72	5mg	QQ客服：215959384
花椒素; Xanthoxylin	CFN97465	90-24-4	C₁₀H₁₂O₄ = 196.2	20mg	QQ客服：215959384
马赛替尼; Masitinib (AB1010)	CFN60373	790299-79-5	C₂₈H₃₀N₆OS = 498.64	5mg	QQ客服：2056216494
大果桉醛E; Macrocarpal E	CFN99470	142628-54-4	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0261 mL	5.1303 mL	10.2605 mL	20.521 mL	25.6513 mL
5 mM	0.2052 mL	1.0261 mL	2.0521 mL	4.1042 mL	5.1303 mL
10 mM	0.1026 mL	0.513 mL	1.0261 mL	2.0521 mL	2.5651 mL
50 mM	0.0205 mL	0.1026 mL	0.2052 mL	0.4104 mL	0.513 mL
100 mM	0.0103 mL	0.0513 mL	0.1026 mL	0.2052 mL	0.2565 mL