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    Tomatidine

    番茄碱
    产品编号 CFN90632
    CAS编号 77-59-8
    分子式 = 分子量 C27H45NO2 = 415.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The fruits of Lycopersicon esculentum Mill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    番茄碱 CFN90632 77-59-8 10mg QQ客服:1413575084
    番茄碱 CFN90632 77-59-8 20mg QQ客服:1413575084
    番茄碱 CFN90632 77-59-8 50mg QQ客服:1413575084
    番茄碱 CFN90632 77-59-8 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mendel University in Brno (Czech Republic)
  • Monash University (Australia)
  • Calcutta University (India)
  • University of Perugia (Italy)
  • University of Zurich (Switzerland)
  • Utrecht University (Netherlands)
  • Universite Libre de Bruxelles (Belgium)
  • Chinese University of Hong Kong (China)
  • University of Oslo (Norway)
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  • University of Dicle (Turkey)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Natural Product Communications2020, doi: 10.1177.
  • Phytomedicine.2019, 61:152813
  • J Food Biochem.2019, 43(9):e12970
  • Biomolecules.2020, 10(6):925.
  • Cells.2022, 11(6):931.
  • Microb Pathog.2019, 131:128-134
  • Phytother Res.2023, 37(10):4587-4606.
  • Plant Archives2020, 2(1),2929-2934
  • Int J Mol Sci.2015, 16(8):18396-411
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • AMB Express2020. 10(1):126.
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Phytomedicine.2018, 47:48-57
  • New Zealand J. Forestry Sci.2014, 44:17
  • Molecules.2022, 27(13):4227.
  • Front Pharmacol.2021, 12:615157.
  • Food Analytical Methods2017, 10:3225-3234
  • Research on Crops.2017, 18(3):569
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Journal of Molecular Liquids2021, 334:116014.
  • Phytomedicine.2019, 55:229-237
  • Molecules.2020, 25(23):5609.
  • ...
  • 生物活性
    Description: Tomatidine shows antibiotic, and anti-inflammatory activities, it significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. Tomatidine inhibits the invasion of A549 cells by reducing the expression of MMPs, also inhibits ERK and Akt signaling pathways and NF-κB activity, suggests a new therapeutic potential for Tomatidine in anti-metastatic therapy.
    Targets: mTOR | Antifection | MMP(e.g.TIMP) | Akt | ERK | NF-kB | PI3K | LDL
    In vitro:
    Eur J Med Chem. 2014 Jun 10;80:605-20.
    Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus.[Pubmed: 24877760]
    Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence.
    METHODS AND RESULTS:
    We have recently demonstrated that tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, tomatidine has shown antibiotic activity against small-colony variants of S. aureus.
    CONCLUSIONS:
    We herein report the first study of the structure-activity relationship of tomatidine against S. aureus.
    Chem Biol Interact. 2013 May 25;203(3):580-7.
    Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.[Pubmed: 23566884]
    Tomatidine is an aglycone of glycoalkaloid tomatine in tomato. Tomatidine is found to possess anti-inflammatory properties and may serve as a chemosensitizer in multidrug-resistant tumor cells. However, the effect of Tomatidine on cancer cell metastasis remains unclear.
    METHODS AND RESULTS:
    This study examines the effect of Tomatidine on the migration and invasion of human lung adenocarcinoma A549 cell in vitro. The data demonstrates that Tomatidine does not effectively inhibit the viability of A549 cells. When treated with non-toxic doses of Tomatidine, cell invasion is markedly suppressed by Boyden chamber invasion assay, while cell migration is not affected. Tomatidine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), as well as tissue inhibitor of metalloproteinase-1 (TIMP-1). The immunoblotting assays indicate that Tomatidine is very effective in suppressing the phosphorylation of Akt and extracellular signal regulating kinase (ERK). In addition, Tomatidine significantly decreases the nuclear level of nuclear factor kappa B (NF-κB), which suggests that Tomatidine inhibits NF-κB activity. Furthermore, the treatment of inhibitors specific for PI3K/Akt (LY294002), ERK (U0126), or NF-κB (pyrrolidine dithiocarbamate) to A549 cells reduced cell invasion and MMP-2/9 expression.
    CONCLUSIONS:
    The results suggest that Tomatidine inhibits the invasion of A549 cells by reducing the expression of MMPs. It also inhibits ERK and Akt signaling pathways and NF-κB activity. These findings demonstrate a new therapeutic potential for Tomatidine in anti-metastatic therapy.
    Antimicrob Agents Chemother. 2011 May;55(5):1937-45.
    Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.[Pubmed: 21357296]
    Small-colony variants (SCVs) often are associated with chronic Staphylococcus aureus infections, such as those encountered by cystic fibrosis (CF) patients.
    METHODS AND RESULTS:
    We report here that tomatidine, the aglycon form of the plant secondary metabolite tomatine, has a potent growth inhibitory activity against SCVs (MIC of 0.12 μg/ml), whereas the growth of normal S. aureus strains was not significantly altered by tomatidine (MIC, >16 μg/ml). The specific action of tomatidine was bacteriostatic for SCVs and was clearly associated with their dysfunctional electron transport system, as the presence of the electron transport inhibitor 4-hydroxy-2-heptylquinoline-N-oxide (HQNO) caused normal S. aureus strains to become susceptible to tomatidine. Inversely, the complementation of SCVs' respiratory deficiency conferred resistance to tomatidine. Tomatidine provoked a general reduction of macromolecular biosynthesis but more specifically affected the incorporation of radiolabeled leucine in proteins of HQNO-treated S. aureus at a concentration corresponding to the MIC against SCVs. Furthermore, tomatidine inhibited the intracellular replication of a clinical SCV in polarized CF-like epithelial cells.
    CONCLUSIONS:
    Our results suggest that tomatidine eventually will find some use in combination therapy with other traditional antibiotics to eliminate persistent forms of S. aureus.
    In vivo:
    J Agric Food Chem. 2012 Mar 14;60(10):2472-9.
    Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT).[Pubmed: 22224814]
    It was previously revealed that esculeoside A, a new glycoalkaloid, and esculeogenin A, a new aglycon of esculeoside A, contained in ripe tomato ameliorate atherosclerosis in apoE-deficent mice.
    METHODS AND RESULTS:
    This study examined whether tomatidine, the aglycone of tomatine, which is a major tomato glycoalkaloid, also shows similar inhibitory effects on cholesterol ester (CE) accumulation in human monocyte-derived macrophages (HMDM) and atherogenesis in apoE-deficient mice. Tomatidine significantly inhibited the CE accumulation induced by acetylated LDL in HMDM in a dose-dependent manner. Tomatidine also inhibited CE formation in Chinese hamster ovary cells overexpressing acyl-CoA:cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that tomatidine suppresses both ACAT-1 and ACAT-2 activities. Furthermore, the oral administration of tomatidine to apoE-deficient mice significantly reduced levels of serum cholesterol, LDL-cholesterol, and areas of atherosclerotic lesions.
    CONCLUSIONS:
    The study provides the first evidence that tomatidine significantly suppresses the activity of ACAT and leads to reduction of atherogenesis.
    ur J Pharmacol . 2020 Sep 5;882:173280.
    Tomatidine protects against ischemic neuronal injury by improving lysosomal function[Pubmed: 32580039]
    Abstract Cerebral ischemia is a severe neurological disorder with limited therapy. Autophagy refers to the intracellular degradation process via an autophagosome-lysosome pathway. Emerging studies indicated the neuroprotective effects of autophagy against ischemic neuronal injury, suggesting the potential neuroprotection of autophagy-inducing compounds. Tomatidine is a gut microbiota-derived metabolite from unripe tomatoes. Tomatidine activates autophagy either in mammal cells or C elegans. However, potential neuroprotection of tomatidine against ischemic neuronal injury has not been determined. In the present investigation, N2a cells and primary cultured mice cortical neurons were subjected to oxygen-glucose deprivation followed by reperfusion (OGD/R). Cell injury was determined by MTT and lactate dehydrogenase release. Autophagosomes and autolysosomes were visualized by transfecting mCherry-GFP-tandem fluorescent LC3. The protein levels of LC3, Cathepsin D, Cathepsin B, and transcription factor EB (TFEB) were detected by Western blot. Lysosomes were stained with LysoTracker Red and dequenched-bovine serum albumin (DQ-BSA red). Tomatidine alleviated OGD/R-induced injury in N2a cells and neurons. Interestingly, tomatidine treatment attenuated, rather than reinforced, the OGD/R-elevated LC3-II, which can be reversed by lysosome inhibitor. These results indicated enhanced lysosomal activity rather than autophagosome generation with tomatidine treatment in our models. Indeed, tomatidine increased the lysosome number, proteolytic activities, as well as the expression of Cathepsin D and Cathepsin B. In addition, tomatidine increased the expression and nucleus translocation of (TFEB). Besides, lysosomal inhibitors chloroquine and bafilomycin, but not wortmannin, abolished the protection of tomatidine. In conclusion, the present study revealed the neuroprotection of tomatidine against ischemic injury by promoting lysosomal activity, possibly with the involvement of TFEB-related mechanisms. Keywords: Autophagy flux; Cerebral ischemia; Lysosomal activation; Neuroprotection; TFEB; Tomatidine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4059 mL 12.0294 mL 24.0587 mL 48.1174 mL 60.1468 mL
    5 mM 0.4812 mL 2.4059 mL 4.8117 mL 9.6235 mL 12.0294 mL
    10 mM 0.2406 mL 1.2029 mL 2.4059 mL 4.8117 mL 6.0147 mL
    50 mM 0.0481 mL 0.2406 mL 0.4812 mL 0.9623 mL 1.2029 mL
    100 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.4812 mL 0.6015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    澳洲茄胺; 澳州茄胺; Solasodine CFN90200 126-17-0 C27H43NO2 = 413.62 20mg QQ客服:215959384
    澳洲茄碱; Solasonine CFN90156 19121-58-5 C45H73NO16 = 884.06 20mg QQ客服:1413575084
    澳洲茄边碱; Solamargine CFN90159 20311-51-7 C45H73NO15 = 868.06 20mg QQ客服:1413575084
    beta-澳洲茄边碱; Khasianine CFN90387 32449-98-2 C39H63NO11 = 721.93 20mg QQ客服:215959384
    Beta-茄边碱; Beta-Solamarine CFN90552 3671-38-3 C45H73NO15 = 868.07 5mg QQ客服:1413575084
    澳茄新碱; Solasurine CFN90553 27028-76-8 C39H63NO11 = 721.92 5mg QQ客服:1457312923
    澳洲边茄碱; Solamarine CFN93102 20318-30-3 C45H73NO16 = 884.1 5mg QQ客服:2056216494
    番茄碱苷; Tomatine CFN90930 17406-45-0 C50H83NO21 = 1034.2 20mg QQ客服:215959384
    垂茄啶; Demissidine CFN70371 474-08-8 C27H45NO = 399.7 5mg QQ客服:1457312923
    茄啶; Solanidine CFN70454 80-78-4 C27H43NO = 397.6 5mg QQ客服:2056216494

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