| Description: |
Peimisine may have antihypertensive action, it can inhibit angiotensin I converting enzyme activity in a dose-dependent manner(the IC50 value of 526.5 microM). Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. It plays a protective role against LPS-induced acute lung injury, and against the experimental hepatic fibrosis formation. |
| Targets: |
NO | SOD | Calcium Channel |
| In vitro: |
| Chinese Traditional & Herbal Drugs, 2009, 40(4):597-601. | | Antiasthmatic mechanism of peimisine in Fritillaria monantha.[Reference: WebLink] | To approach the antiasthmatic mechanism of peimisine in Fritillaria monatha.
METHODS AND RESULTS:
To observe the effect of peimisine in the different concentration on the tracheal smooth muscle contraction in vitro organ induced by Ach, His, β-receptor, CaCl 2, Pro, in nitricoxide synthase catastaltica. Peimisine (0.046 and 0.092 mmol/L) made the EC 50 induced by Ach increased; The EC 50 of peimsine (0.092 mmol/L) was not changed by His; The EC 50 of peimisine (0.092 mmol/L) was not significantly different to tracheal smooth muscle contraction induced by CaCl 2; Three dosages of peimisine had significant inhibition on the release of intracellular calcium induced by CaCl 2 (P < 0.05, 0.01, and 0.001) in a dose-dependent manner. But extracellular calcium influx was not significantly inhibited. Comparing with the L-NAME+dissolvant group, three dosages of peimisine couldn't restrain the contraction and had no significant difference.
CONCLUSIONS:
Peimisine could affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma.
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| In vivo: |
| Lishizhen Medicine & Materia Medica Research, 2014, 8(13-14):1842-7. | | Peimisine attenuates acute lung injury induced by lipopolysaccharide in mice[Reference: WebLink] | To determine the protective effect of Peimisine on acute lung injury( ALI) induced by lipopolysaccharide( LPS) and its protective mechanism mice.
METHODS AND RESULTS:
The mice were randomly allocated into sham,LPS and Peimisine + LPS groups. The ALI mice was induced by LPS after etherization. The Peimisine was injected by belly cavity 30 minutes prior to the LPS challenge,one time/d,3 times totally. The mice were killed 24h after the third Peimisine injection to observe the amount of LDH,MDA in plasma,the lung tissue pathology,the total protein,white blood cell and differential count in the bronchoalveolar lavage fluid( BALF). LDH,MDA amount in plasma,Lung tissue,and BALF showed serious inflammatory changes in the LPS group. Compared with the LPS group,Peimisine attenuates Lung tissue injury,LDH and MDA amount in ALI mice in a dose dependent manner. Peimisine( 0. 12mg) lowered the total protein,total white blood cells,lymphocyte and neutrophilic leukocyte in BALF compared with the LPS group.
CONCLUSIONS:
Peimisine can play a protective role against LPS-induced acute lung injury. |
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