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  • 茶黄素

    Theaflavin

    茶黄素
    产品编号 CFN98597
    CAS编号 4670-05-7
    分子式 = 分子量 C29H24O12 = 564.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The leaves of Camellia sinensis (L.) O. Kuntze.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    茶黄素 CFN98597 4670-05-7 10mg QQ客服:1413575084
    茶黄素 CFN98597 4670-05-7 20mg QQ客服:1413575084
    茶黄素 CFN98597 4670-05-7 50mg QQ客服:1413575084
    茶黄素 CFN98597 4670-05-7 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chulalongkorn University (Thailand)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Virginia (USA)
  • University of Sao Paulo (Brazil)
  • Siksha O Anusandhan University (India)
  • Harvard University (USA)
  • Medical University of Gdansk (Poland)
  • University of Medicine and Pharmacy (Romania)
  • Center for protein Engineering (CIP) (Belgium)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Biotech R&D Institute (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Asian Nat Prod Res.2019, 5:1-17
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Food Chem.2017, 221:1135-1144
  • J Adv Res.2021, 35:245-257.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Molecules2022, 27(12):3824.
  • Agronomy2020, 10(3),388.
  • Arch Biochem Biophys.2020, 687:108363.
  • Sci Rep. 2018, 462(8)
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Journal of functional foods2018, 171-182
  • Inflammation.2020, 43(5):1716-1728.
  • Environ Toxicol.2019, 34(4):513-520.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Saf Health Work.2019, 10(2):196-204
  • Cancers (Basel).2023, 15(1):293.
  • Molecules.2019, 24(11):E2044
  • Front Microbiol.2022, 12:833233.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Lab Chip.2018, 18(6):971-978
  • J Ethnopharmacol.2022, 289:115018.
  • ...
  • 生物活性
    Description: Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase, which has anti-inflammatory, antioxidative, anti-mutagenic, anti-HSV-1, and anti-carcinogenic properties. Theaflavin is active in the prevention of fatty liver and obesity, it can significantly reduce lipid accumulation, suppress fatty acid synthesis, and stimulate fatty acid oxidation. Theaflavin inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 expression in bone marrow-derived macrophages through the blockade of NF-κB and MAPK signaling pathways; it also protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease.
    Targets: Antifection | ROS | TNF-α | NF-kB | IL Receptor | IkB | ERK | JNK | p38MAPK | Caspase | AMPK | IKK | H1N1 | HSV-1 | MCP-1 | ICAM-1 | FAS
    In vitro:
    J Microbiol Biotechnol. 2013 Sep 28;23(9):1322-6.
    Antifungal synergy of theaflavin and epicatechin combinations against Candida albicans.[Pubmed: 23711519]
    New antifungal agents are required to compensate for the increase in resistance to standard antifungal agents of Candida albicans, which is an important opportunistic fungal pathogen that causes minor infections in many individuals but very serious infections in those who are immune-compromised.
    METHODS AND RESULTS:
    In this study, combinations of theaflavin and epicatechin are investigated as potential antifungal agents and also to establish whether antifungal synergy exists between these two readily accessible and cost-effective polyphenols isolated from black and green tea. The results of disc diffusion assays showed stronger antibacterial activity of theaflavin:epicatechin combinations against C. albicans NCTC 3255 and NCTC 3179, than that of theaflavin alone. Minimum inhibitory concentrations (MICs) of 1,024 μg/ml with theaflavin and 128-256 μg/ml with theaflavin:epicatechin combinations were found. The fractional inhibitory concentration indexes were calculated, and the synergy between theaflavin and epicatechin against both isolates of C. albicans was confirmed.
    CONCLUSIONS:
    Theaflavin:epicatechin combinations show real potential for future use as a treatment for infections caused by C. albicans.
    Genomics Inform . 2016 Sep;14(3):96-103.
    Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking[Pubmed: 27729839]
    Abstract The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1. It is responsible for sialic acid cleavage from glycans of the infected cell. We employed amino acid sequence of H1N1 NA to predict the tertiary structure using Phyre2 server and validated using ProCheck, ProSA, ProQ, and ERRAT server. Further, the modelled structure was docked with thirteen natural compounds of plant origin using AutoDock4.2. Most of the natural compounds showed effective inhibitory activity against H1N1 NA in binding condition. This study also highlights interaction of these natural inhibitors with amino residues of NA protein. Furthermore, among 13 natural compounds, theaflavin, found in green tea, was observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Hence, it may be of interest to consider theaflavin for further in vitro and in vivo evaluation. Keywords: influenza A Virus; molecular docking analysis; neuraminidase; phytochemicals.
    In vivo:
    Biochem Biophys Res Commun. 2012 Jan 6;417(1):287-93.
    Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model.[Pubmed: 22155236]
    The incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing, and there is a shortage of liver donors, which has led to the acceptance of steatotic livers for transplantation. However, steatotic livers are known to experience more severe acute ischemia-reperfusion (I/R) injury than normal livers upon transplantation. In the present study, we investigated the role of theaflavin, a polyphenol substance extracted from black tea, in attenuating acute I/R injury in a fatty liver model.
    METHODS AND RESULTS:
    We induced I/R in normal and steatotic livers treated with or without theaflavin. We also separated primary hepatocytes from the normal and steatotic livers, and applied RAW264.7 cells, a mouse macrophage cell line, that was pretreated with theaflavin. We observed that liver steatosis, oxidative stress, inflammation and hepatocyte apoptosis were increased in the steatotic liver compared to the normal liver, however, these changes were significantly decreased by theaflavin treatment. In addition, theaflavin significantly diminished the ROS production of steatotic hepatocytes and TNF-α production by LPS-stimulated RAW264.7 cells.
    CONCLUSIONS:
    We concluded that theaflavin has protective effects against I/R injury in fatty livers by anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.
    J Lipid Res. 2007 Nov;48(11):2334-43.
    Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells.[Pubmed: 17720960 ]
    Black tea is one of the world's most popular beverages, and its health-promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these phenomena remain unclear.
    METHODS AND RESULTS:
    In the present study, the black tea major component theaflavins were assessed for their hepatic lipid-lowering potential when administered in fatty acid overload conditions both in cell culture and in an animal experimental model. We found that theaflavins significantly reduced lipid accumulation, suppressed fatty acid synthesis, and stimulated fatty acid oxidation. Furthermore, theaflavins also inhibited acetyl-coenzyme A carboxylase activities by stimulating AMP-activated protein kinase (AMPK) through the LKB1 and reactive oxygen species pathways. These observations support the idea that AMPK is a critical component of decreased hepatic lipid accumulation by theaflavin treatments.
    CONCLUSIONS:
    Our results show that theaflavins are bioavailable both in vitro and in vivo and may be active in the prevention of fatty liver and obesity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7715 mL 8.8576 mL 17.7151 mL 35.4302 mL 44.2878 mL
    5 mM 0.3543 mL 1.7715 mL 3.543 mL 7.086 mL 8.8576 mL
    10 mM 0.1772 mL 0.8858 mL 1.7715 mL 3.543 mL 4.4288 mL
    50 mM 0.0354 mL 0.1772 mL 0.3543 mL 0.7086 mL 0.8858 mL
    100 mM 0.0177 mL 0.0886 mL 0.1772 mL 0.3543 mL 0.4429 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茶黄素; Theaflavin CFN98597 4670-05-7 C29H24O12 = 564.49 20mg QQ客服:3257982914
    茶黄素 3'-没食子酸酯; Theaflavin-3'-gallate CFN98599 28543-07-9 C36H28O16 = 716.6 20mg QQ客服:2159513211
    茶黄素 3-没食子酸酯; Theaflavin-3-gallate CFN90170 30462-34-1 C36H28O16 = 716.60 20mg QQ客服:2159513211
    3,3'-二没食子酸酯茶黄素; Theaflavin 3,3'-di-O-gallate CFN99130 30462-35-2 C43H32O20 = 868.70 20mg QQ客服:3257982914
    (2R)-8-Methylsocotrin-4'-ol; (2R)-8-Methylsocotrin-4'-ol CFN92834 956103-75-6 C32H32O6 = 512.6 5mg QQ客服:1413575084
    血竭黄烷A; Dracoflavan A CFN92681 132185-42-3 C49H46O10 = 794.9 5mg QQ客服:1457312923
    狼毒色酮; Chamaechromone CFN92815 93413-00-4 C30H22O10 = 542.5 5mg QQ客服:1413575084

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