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  • L-四氢小檗碱

    Tetrahydroberberine

    L-四氢小檗碱
    产品编号 CFN90506
    CAS编号 522-97-4
    分子式 = 分子量 C20H21O4N = 339.38
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Alkaloids
    植物来源 The barks of Phellodendron chinense Schneid.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    L-四氢小檗碱 CFN90506 522-97-4 10mg QQ客服:2056216494
    L-四氢小檗碱 CFN90506 522-97-4 20mg QQ客服:2056216494
    L-四氢小檗碱 CFN90506 522-97-4 50mg QQ客服:2056216494
    L-四氢小檗碱 CFN90506 522-97-4 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Utrecht University (Netherlands)
  • Northeast Normal University Changchun (China)
  • Universit?t Basel (Switzerland)
  • University of Helsinki (Finland)
  • China Medical University (Taiwan)
  • Semmelweis Unicersity (Hungary)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Complutense University of Madrid (Spain)
  • Srinakharinwirot University (Thailand)
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  • University of Toronto (Canada)
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  • Ain Shams University (Egypt)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cancers (Basel).2021, 13(17):4327.
  • Oncol Rep.2019, 41(4):2453-2463
  • Int J Mol Sci.2023, 24(3):2102.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Metabolites.2023, 13(6):689.
  • Int J Mol Sci.2017, 18(12)
  • mBio.2020, 11(3):e00686-20.
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Sci Rep.2019, 9:12132
  • Phytomedicine.2024, 129:155645.
  • Nat Plants.2016, 3:16205
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • LWT2021, 138:110397.
  • Anticancer Res.2024, 44(3):1033-1044.
  • Am J Chin Med.2022, 1-20.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Phytomedicine.2024, 125:155350.
  • JEJU National University2022, 24032.
  • Front Neurosci.2019, 13:1091
  • Food Science and Human Wellness2022, 11(4):965-974
  • Molecules.2022, 27(7):2116.
  • Kasetsart University2022, ethesis.1144.
  • ...
  • 生物活性
    Description: Tetrahydroberberine, with D(2) receptor antagonist and 5-HT(1A) receptor agonist properties, has significant potential as a therapeutic for treatment of FD; it has antidopaminergic effect, and other pharmacological action on the central nervous system. Tetrahydroberberine can inhibit the rabbit platelet aggregation.
    Targets: 5-HT Receptor | Dopamine Receptor
    In vitro:
    Acta Crystallogr C Struct Chem. 2015 Apr;71(Pt 4):262-5.
    Tetrahydroberberine, a pharmacologically active naturally occurring alkaloid.[Pubmed: 25836282]

    METHODS AND RESULTS:
    Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72 (5)° between the arene rings at the two ends of the reduced quinolizinium core.
    CONCLUSIONS:
    The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benzodioxole -CH2···OCH3 and -OCH3···OCH3 interactions between neighboring molecules.
    In vivo:
    J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
    Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function.[Pubmed: 21659472]

    METHODS AND RESULTS:
    Oral administration of Tetrahydroberberine not only resulted in significantly accelerated gastric emptying of normal rats in a bell-shaped relationship, with a maximal efficacy at a dose of 30 μg/kg, but also restored the delayed gastric emptying caused by apomorphine, which might be mediated by an antidopaminergic effect. Data from electromyography indicated enhanced motor function of the upper gastrointestinal tract by Tetrahydroberberine , which occurred through strengthening contractility and shortening the contraction interval. Oral administration of Tetrahydroberberine resulted in a drastic increase of gastric accommodation in Beagle dogTetrahydroberberine(30 μg/kg, p < 0.01) and comparable with that of sumatriptan (3 mg/kg), a potent fundic relaxant.
    CONCLUSIONS:
    Taken together, our data suggested that Tetrahydroberberine, with D(2) receptor antagonist and 5-HT(1A) receptor agonist properties, has significant potential as a therapeutic for treatment of FD.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9465 mL 14.7327 mL 29.4655 mL 58.931 mL 73.6637 mL
    5 mM 0.5893 mL 2.9465 mL 5.8931 mL 11.7862 mL 14.7327 mL
    10 mM 0.2947 mL 1.4733 mL 2.9465 mL 5.8931 mL 7.3664 mL
    50 mM 0.0589 mL 0.2947 mL 0.5893 mL 1.1786 mL 1.4733 mL
    100 mM 0.0295 mL 0.1473 mL 0.2947 mL 0.5893 mL 0.7366 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Epicorynoxidine; Epicorynoxidine CFN89271 58000-48-9 C21H25NO5 = 371.43 5mg QQ客服:2159513211
    N-甲基紫堇达明碱; N-Methylcorydalmine CFN95204 81010-29-9 C21H25NO4 = 355.4 5mg QQ客服:1413575084
    右旋四氢巴马汀; D-Tetrahydropalmatine CFN90188 3520-14-7 C21H25NO4 = 355.41 20mg QQ客服:1413575084
    四氢黄连碱,人血草碱; Tetrahydrocoptisine CFN90416 7461-02-1 C19H17NO4 = 323.12 20mg QQ客服:215959384
    盐酸人血草碱; Stylopine hydrochloride CFN96656 96087-21-7 C19H18ClNO4 = 359.81 5mg QQ客服:2159513211
    左旋千金藤啶碱; L-Stepholidine CFN90457 16562-13-3 C19H21NO4 = 327.37 20mg QQ客服:3257982914
    (S)-金黄紫堇碱; Scoulerine CFN96330 6451-73-6 C19H21NO4 = 327.4 5mg QQ客服:2056216494
    L-四氢小檗碱; Tetrahydroberberine CFN90506 522-97-4 C20H21O4N = 339.38 20mg QQ客服:3257982914
    华紫堇碱;碎叶紫堇碱; Cheilanthifoline CFN90945 483-44-3 C19H19NO4 = 325.36 10mg QQ客服:2159513211
    四氢表小檗碱; Tetrahydroepiberberine CFN90507 38853-67-7 C20H21NO4 = 339.15 10mg QQ客服:215959384

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