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  • Tessaric acid

    Tessaric acid

    Tessaric acid
    产品编号 CFN95182
    CAS编号 58142-10-2
    分子式 = 分子量 C15H20O3 = 248.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Tessaria absinthioides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Tessaric acid CFN95182 58142-10-2 1mg QQ客服:3257982914
    Tessaric acid CFN95182 58142-10-2 5mg QQ客服:3257982914
    Tessaric acid CFN95182 58142-10-2 10mg QQ客服:3257982914
    Tessaric acid CFN95182 58142-10-2 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Celltrion Chemical Research Institute (Korea)
  • Utrecht University (Netherlands)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Wroclaw Medical University (Poland)
  • John Innes Centre (United Kingdom)
  • Yale University (USA)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Tohoku University (Japan)
  • Lodz University of Technology (Poland)
  • Charles University in Prague (Czech Republic)
  • University of Liège (Belgium)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of the Basque Country (Spain)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Neurochem Res.2021, s11064-021-03449-0
  • Food Research2022, 6(6): 30-38.
  • J Biomol Struct Dyn.2022, 1-21.
  • Biomed Pharmacother.2021, 144:112300.
  • Sains Malaysiana2022, 51(4):1143-1154
  • J Ethnopharmacol.2016, 194:219-227
  • J Pharmaceut Biomed2020, 178:112894
  • Sci Rep.2023, 13(1):21690.
  • Integr Med Res.2021, 10(3):100723.
  • Nutrients.2018, 10(10)
  • Neuropharmacology.2018, 131:68-82
  • Phytomedicine.2021, 84:153501.
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Appl. Sci.2020, 10(4),1304
  • Plant Cell Tiss Org2020, 1-16
  • Oncology Letters2018, 4690-4696
  • Plant Physiol Biochem.2019, 144:355-364
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Phytochem Anal.2013, 24(5):493-503
  • Free Radic Biol Med.2021, 166:104-115.
  • ACS Chem Biol.2019, 14(5):873-881
  • Biomimetics (Basel).2022, 7(4):154.
  • Molecules.2019, 24(6):E1177
  • ...
  • 生物活性
    Description: Tessaric acid has antifeedant and allelochemical effects. Tessaric acid derivatives induce G/M cell cycle arrest in human solid tumor cell lines.
    In vitro:
    Bioorg Med Chem. 2009 Sep 1;17(17):6251-6.
    Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.[Pubmed: 19664930 ]

    METHODS AND RESULTS:
    A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 microM.
    CONCLUSIONS:
    Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
    Z Naturforsch C. 2005 Nov-Dec;60(11-12):855-61.
    Antifeedant/insecticidal terpenes from asteraceae and labiatae species native to Argentinean semi-arid lands.[Pubmed: 16402545 ]
    To validate the potential as added-value resources of Asteraceae and Labiatae species of Argentinean semi-arid lands, we have selected 13 of their major terpenoids belonging to several chemical classes and tested their insect antifeedant and toxic activity on the herbivorous insects Spodoptera littoralis and Leptinotarsa decemlineata.
    METHODS AND RESULTS:
    The antifeedant effects of the test compounds were structure- and species-dependent. The most active antifeedant to L. decemlineata was the eudesmane sesquiterpene gamma-costic acid (13), followed by the labdane diterpene 2alpha,3alpha-dihydroxycativic acid (8), the clerodane diterpenes 6-acetylteucjaponin B (5), bacchotricuneatin A (1), bartemidiolide (7), butanolide (4), and the sesquiterpenes ilicic acid (11) and tessaric acid (10) (eudesmane and eremophilane type, respectively). S. littoralis was only affected by the clerodanes and showed the strongest response to salviarin (3) and 5, followed by hawtriwaic acid (6) and 12-epi-bacchotricuneatin A (2).
    CONCLUSIONS:
    Orally injected S. littoralis larvae were negatively affected by 5. Most of the diterpenes had selective cytotoxic effects to insect-derived Sf9 cells with the clerodane 1 being the most active, followed by the eudesmane costic acid (12), the only cytotoxic sesquiterpene. None of these compounds was cytotoxic to mammalian CHO cells.
    J Chem Ecol. 2003 Jan;29(1):175-87.
    Allelochemical effects of eudesmane and eremophilane sesquiterpenes on Tribolium castaneum larvae.[Pubmed: 12647861]

    METHODS AND RESULTS:
    Eight eudesmane and eremophilane sesquiterpenes administered to Tribolium castaneum larvae caused different allelochemical effects. Topical application of 3-oxo-gamma-costic acid produced the greatest lengthening in the duration of the pupal stage. Morphological deformities were found, specifically when ilicic, costic, and gamma-costic acids and costic aldehyde were used. Ilicic acid exhibited the major toxicity 72 hr following topical application. All compounds were significantly toxic at the end point of the experiment (60 days). Treated surface toxicity was lower than when topical assays were carried out.
    CONCLUSIONS:
    Responses to tessaric acid in choice bioassays had the highest attractive effect. Maximum repellency was caused by the 3-oxo-gamma-costic acid. However, experimental series carried out using gamma-costic acid, eremophilan-1(10),2,11(13)-trien-12-oic acid, costic aldehyde, and ilicic aldehyde showed no clear response.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0274 mL 20.1369 mL 40.2739 mL 80.5477 mL 100.6847 mL
    5 mM 0.8055 mL 4.0274 mL 8.0548 mL 16.1095 mL 20.1369 mL
    10 mM 0.4027 mL 2.0137 mL 4.0274 mL 8.0548 mL 10.0685 mL
    50 mM 0.0805 mL 0.4027 mL 0.8055 mL 1.611 mL 2.0137 mL
    100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8055 mL 1.0068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Nardoaristolone B; Nardoaristolone B CFN95203 1422517-82-5 C14H18O2 = 218.3 5mg QQ客服:2159513211
    甘松香酮 A; Kanshone A CFN96977 115356-18-8 C15H22O2 = 234.33 5mg QQ客服:215959384
    甘松新酮二醇; Nardosinonediol CFN89546 20489-11-6 C15H24O3 = 252.34 5mg QQ客服:215959384
    异甘松新酮; Isonardosinone CFN95180 27062-01-7 C15H20O4 = 264.3 10mg QQ客服:215959384
    Narchinol B; Narchinol B CFN89522 1356822-09-7 C12H16O3 = 208.25 5mg QQ客服:2159513211
    Desoxo-narchinol A; Desoxo-narchinol A CFN89358 53859-06-6 C12H16O2 = 192.25 5mg QQ客服:2159513211
    努特卡酮, 诺卡酮; Nootkatone CFN98699 4674-50-4 C15H22O = 218.3 20mg QQ客服:3257982914
    Oxyphyllol B; Oxyphyllol B CFN95575 226546-99-2 C15H22O2 = 234.3 5mg QQ客服:3257982914
    Tessaric acid; Tessaric acid CFN95182 58142-10-2 C15H20O3 = 248.3 5mg QQ客服:2056216494
    苷松新酮; Nardosinone CFN90178 23720-80-1 C15H22O3 = 250.33 20mg QQ客服:2056216494

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