蒺藜皂苷D

Terrestrosin D

	产品编号	CFN90821
	CAS编号	179464-23-4
	分子式 = 分子量	C₅₀H₈₀O₂₃ = 1049.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The herbs of Tribulus terrestris L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
蒺藜皂苷D	CFN90821	179464-23-4	1mg	QQ客服：2159513211
蒺藜皂苷D	CFN90821	179464-23-4	5mg	QQ客服：2159513211
蒺藜皂苷D	CFN90821	179464-23-4	10mg	QQ客服：2159513211
蒺藜皂苷D	CFN90821	179464-23-4	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Cancer Center Research Institute (Japan)

Universiti Sains Malaysia (Malaysia)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Universidad de La Salle (Mexico)

Chang Gung University (Taiwan)

University of British Columbia (Canada)

University of Maryland School of Medicine (USA)

University of Fribourg (Switzerland)

University of Hertfordshire (United Kingdom)

Uniwersytet Gdański (Poland)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Florida International University (USA)

Indian Institute of Science (India)

Max Rubner-Institut (MRI) (Germany)

More...

Description:

Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of terrestrosin D.

Targets:

VEGFR

In vitro:

Pathobiology. 2014;81(3):123-32.

Terrestrosin D, a steroidal saponin from Tribulus terrestris L., inhibits growth and angiogenesis of human prostate cancer in vitro and in vivo.[Pubmed: 24642631]

The aim of this study was to investigate whether terrestrosin D (TED) inhibits the progression of castration-resistant prostate cancer and consider its mechanism.
METHODS AND RESULTS:
Cell cycle, mitochondrial membrane potential (ΔΨm) and apoptosis were determined by flow cytometry. Caspase-3 activity and vascular endothelial growth factor secretion were detected by a caspase-3 assay and human vascular endothelial growth factor kit, respectively. A PC-3 xenograft mouse model was used to evaluate the anticancer effect of TED in vivo. In vitro, TED strongly suppressed the growth of prostate cancer cells and endothelial cells in a dose-dependent manner. TED induced cell cycle arrest and apoptosis in PC-3 cells and human umbilical vascular endothelial cells (HUVECs). TED-induced apoptosis did not involve the caspase pathway. TED also decreased ΔΨm in PC-3 cells and HUVECs. In vivo, TED significantly suppressed tumor growth in nude mice bearing PC-3 cells, without any overt toxicity. Immunohistochemical analysis showed TED induced apoptotic cell death and inhibited angiogenesis in xenograft tumor cells.
CONCLUSIONS:
Cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of TED.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
重楼皂苷B; Polyphyllin B	CFN90700	50773-42-7	C₅₁H₈₂O₂₀ = 1015.18	20mg	QQ客服：2056216494
盾叶薯蓣皂苷I,盾叶新苷; Zingiberen newsaponin	CFN90832	91653-50-8	C₅₁H₈₂O₂₂ = 1047.2	5mg	QQ客服：3257982914
重楼皂苷VII; Chonglou Saponin VII	CFN97162	68124-04-9	C₅₁H₈₂O₂₁ = 1031.2	20mg	QQ客服：1413575084
蒺藜皂苷D; Terrestrosin D	CFN90821	179464-23-4	C₅₀H₈₀O₂₃ = 1049.2	10mg	QQ客服：215959384
刺蒺藜素; Tribulosin	CFN70451	79974-46-2	C₅₅H₉₀O₂₅ = 1151.3	5mg	QQ客服：2159513211
洋地黄皂苷，毛地黄皂苷; Digitonin	CFN92831	11024-24-1	C₅₆H₉₂O₂₉ = 1229.3	20mg	QQ客服：1413575084
重楼皂苷VI; Polyphyllin VI	CFN99954	55916-51-3	C₃₉H₆₂O₁₃ = 738.91	20mg	QQ客服：1413575084
Mannioside A; Mannioside A	CFN99055	1038922-95-0	C₃₉H₆₂O₁₃ = 738.9	5mg	QQ客服：3257982914
麦冬皂苷Ra，麦冬皂苷1，麦冬苷元-3-O-新橙皮糖苷; Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside	CFN90638	128502-94-3	C₃₉H₆₂O₁₄ = 754.9	10mg	QQ客服：2159513211
25(27)-Ene-elephanoside H; 25(27)-Ene-elephanoside H	CFN95776	1592406-40-0	C₃₉H₆₀O₁₄ = 752.9	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9531 mL	4.7655 mL	9.5311 mL	19.0621 mL	23.8277 mL
5 mM	0.1906 mL	0.9531 mL	1.9062 mL	3.8124 mL	4.7655 mL
10 mM	0.0953 mL	0.4766 mL	0.9531 mL	1.9062 mL	2.3828 mL
50 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.3812 mL	0.4766 mL
100 mM	0.0095 mL	0.0477 mL	0.0953 mL	0.1906 mL	0.2383 mL