通关藤苷H

Tenacissoside H

	产品编号	CFN90428
	CAS编号	191729-45-0
	分子式 = 分子量	C₄₂H₆₆O₁₄ = 794.97
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The herbs of Marsdenia tenacissima
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
通关藤苷H	CFN90428	191729-45-0	10mg	QQ客服：215959384
通关藤苷H	CFN90428	191729-45-0	20mg	QQ客服：215959384
通关藤苷H	CFN90428	191729-45-0	50mg	QQ客服：215959384
通关藤苷H	CFN90428	191729-45-0	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Florida International University (USA)

Kyung Hee University (Korea)

Regional Crop Research Institute (Korea)

Korea Food Research Institute(KFRI) (Korea)

The Australian National University (Australia)

Universidade Federal de Goias (UFG) (Brazil)

Ain Shams University (Egypt)

University of Perugia (Italy)

University of Illinois (USA)

Aarhus University (Denmark)

Uniwersytet Gdański (Poland)

University of Madras (India)

Instituto Politécnico de Bragan?a (Portugal)

Technical University of Denmark (Denmark)

More...

Description:

Tenacissoside H has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.

Targets:

PI3K | NF-kB | PI3K | Akt

In vivo:

Evid Based Complement Alternat Med. 2015; 2015: 464937.

Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade[Pubmed: 26495015]

The purpose of the study was to elucidate the molecular mechanism of Tenacissoside H (TDH) inhibiting esophageal carcinoma infiltration and proliferation.
METHODS AND RESULTS:
In vitro, EC9706 cells were treated with TDH. Cells proliferation and cell cycle were assayed. PI3K and NF-κB mRNAs expression were determined by real time PCR. In vivo, model of nude mice with tumor was established. Mice were treated with TDH. Inhibition ratio of tumor volume was calculated. PCNA expression was examined. Protein expression in PI3K/Akt-NF-κB signaling pathway was determined. In vitro, TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). In vivo, TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05).
CONCLUSIONS:
TDH inhibited esophageal carcinoma infiltration and proliferation both in vitro and in vivo. The anticancer activity has relation to arresting the cell cycle at the S phase, inhibited the PCNA expression of transplanted tumors in nude mice, and regulated the protein expression in the PI3K/Akt-NF-κB transduction cascade.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
通关藤苷H; Tenacissoside H	CFN90428	191729-45-0	C₄₂H₆₆O₁₄ = 794.97	20mg	QQ客服：2056216494
通关藤苷G; Tenacissoside G	CFN97795	191729-43-8	C₄₂H₆₄O₁₄ = 792.96	20mg	QQ客服：2159513211
通关藤苷I; Tenacissoside I	CFN97794	191729-44-9	C₄₄H₆₂O₁₄ = 814.97	20mg	QQ客服：1413575084
苦绳苷D; Dregeoside Da1	CFN97890	98665-65-7	C₄₂H₇₀O₁₅ = 815.0	5mg	QQ客服：2056216494
苦绳甙Ga1; Dregeoside Ga1	CFN97588	98665-66-8	C₄₉H₈₀O₁₇ = 941.17	5mg	QQ客服：2056216494
苦绳甙Aa1; Dregeoside Aa1	CFN97790	20230-41-5	C₄₉H₇₈O₁₇ = 939.15	5mg	QQ客服：1457312923
青阳参苷F ; Otophylloside F	CFN89258	250217-73-3	C₄₈H₇₆O₁₆ = 909.11	5mg	QQ客服：2056216494
青阳参苷B; Otophylloside B	CFN96964	106758-54-7	C₄₉H₇₈O₁₆ = 923.13	5mg	QQ客服：1457312923
青阳参苷元A; Qingyangshengenin A	CFN80437	106644-33-1	C₄₉H₇₂O₁₇ = 933.09	5mg	QQ客服：2056216494
苦绳苷A11; Dregeoside A11	CFN96087	89020-11-1	C₅₅H₈₈O₂₂ = 1101.3	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2579 mL	6.2895 mL	12.5791 mL	25.1582 mL	31.4477 mL
5 mM	0.2516 mL	1.2579 mL	2.5158 mL	5.0316 mL	6.2895 mL
10 mM	0.1258 mL	0.629 mL	1.2579 mL	2.5158 mL	3.1448 mL
50 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.5032 mL	0.629 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.2516 mL	0.3145 mL