Taxin B

	产品编号	CFN96637
	CAS编号	168109-52-2
	分子式 = 分子量	C₂₈H₃₈O₁₀ = 534.60
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The seeds of Taxus mairei.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Taxin B	CFN96637	168109-52-2	1mg	QQ客服：3257982914
Taxin B	CFN96637	168109-52-2	5mg	QQ客服：3257982914
Taxin B	CFN96637	168109-52-2	10mg	QQ客服：3257982914
Taxin B	CFN96637	168109-52-2	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

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IF=12.804(2019)

PMID: 30417089

Northeast Normal University Changchun (China)

Universidade do Porto (Portugal)

Florida A&M University (USA)

St. Jude Children Research Hospital (USA)

University of Fribourg (Switzerland)

Universite Libre de Bruxelles (Belgium)

Indian Institute of Science (India)

Chungnam National University (Korea)

Chang Gung University (Taiwan)

CSIRO - Agriculture Flagship (Australia)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Tohoku University (Japan)

Helmholtz Zentrum München (Germany)

University of Toulouse (France)

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Description:

Taxin B has toxic effects.

In vivo:

Neuro Endocrinol Lett. 2013;34 Suppl 2:130-3.

Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis.[Pubmed: 24362105]

Toxic effects of the yew have been known since ancient times. Yew toxicity is due to the content of cyanogenic glycosides and a mixture of alkaloids known as taxines. Taxine B is probably responsible for the most part of adverse effects in poisoned organisms. This particular taxoid is common in body fluids of the yew-poisoned. The present study is engaged with laboratory examination to confirm substances that lead to fatality of a pair of olive baboons (Papio anubis) following ingestion of yew seeds. When both cage mates (male and female) died suddenly, poisoning was suspected because many berries had fallen into the cage from a nearby fruiting yew tree (Taxus baccata) during the windy night before.
METHODS AND RESULTS:
The analysis was performed using electrospray ionization quadrupole time-of-flight mass spectrometry. A flow injection analysis/mass spectrometry setting was prepared for this purpose. The above mentioned mass spectrometry analysis of taxoids confirmed poisoning by taxanes. The presence of Taxin B/isoTaxin B was confirmed in all investigated samples. Apparently in urine and bile there were concentrations ranging 150-220 ng.mL-1 and in blood serum concentrations 25-30 ng.mL-1.
CONCLUSIONS:
It follows from the results obtained that we confirmed that baboons were deadly intoxicated by yew fruits.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8706 mL	9.3528 mL	18.7056 mL	37.4111 mL	46.7639 mL
5 mM	0.3741 mL	1.8706 mL	3.7411 mL	7.4822 mL	9.3528 mL
10 mM	0.1871 mL	0.9353 mL	1.8706 mL	3.7411 mL	4.6764 mL
50 mM	0.0374 mL	0.1871 mL	0.3741 mL	0.7482 mL	0.9353 mL
100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.3741 mL	0.4676 mL