Taxin B

	产品编号	CFN96637
	CAS编号	168109-52-2
	分子式 = 分子量	C₂₈H₃₈O₁₀ = 534.60
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The seeds of Taxus mairei.
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产品名称	产品编号	CAS编号	包装	QQ客服
Taxin B	CFN96637	168109-52-2	1mg	QQ客服：215959384
Taxin B	CFN96637	168109-52-2	5mg	QQ客服：215959384
Taxin B	CFN96637	168109-52-2	10mg	QQ客服：215959384
Taxin B	CFN96637	168109-52-2	20mg	QQ客服：215959384

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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doi: 10.1038/nplants.2016.205.
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doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Shanghai Institute of Organic Chemistry (China)

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University of Parma (Italy)

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Description:

Taxin B has toxic effects.

In vivo:

Neuro Endocrinol Lett. 2013;34 Suppl 2:130-3.

Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis.[Pubmed: 24362105]

Toxic effects of the yew have been known since ancient times. Yew toxicity is due to the content of cyanogenic glycosides and a mixture of alkaloids known as taxines. Taxine B is probably responsible for the most part of adverse effects in poisoned organisms. This particular taxoid is common in body fluids of the yew-poisoned. The present study is engaged with laboratory examination to confirm substances that lead to fatality of a pair of olive baboons (Papio anubis) following ingestion of yew seeds. When both cage mates (male and female) died suddenly, poisoning was suspected because many berries had fallen into the cage from a nearby fruiting yew tree (Taxus baccata) during the windy night before.
METHODS AND RESULTS:
The analysis was performed using electrospray ionization quadrupole time-of-flight mass spectrometry. A flow injection analysis/mass spectrometry setting was prepared for this purpose. The above mentioned mass spectrometry analysis of taxoids confirmed poisoning by taxanes. The presence of Taxin B/isoTaxin B was confirmed in all investigated samples. Apparently in urine and bile there were concentrations ranging 150-220 ng.mL-1 and in blood serum concentrations 25-30 ng.mL-1.
CONCLUSIONS:
It follows from the results obtained that we confirmed that baboons were deadly intoxicated by yew fruits.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
薄荷酮; Piperitone	CFN70490	89-81-6	C₁₀H₁₆O = 152.2	5mg	QQ客服：215959384
Koenimbine; Koenimbine	CFN91189	21087-98-9	C₁₉H₁₉NO₂ = 293.4	5mg	QQ客服：1457312923
密力特苷; Melittoside	CFN93097	19467-03-9	C₂₁H₃₂O₁₅ = 524.47	20mg	QQ客服：2159513211
穗花杉双黄酮；阿曼托黄酮; Amentoflavone	CFN99526	1617-53-4	C₃₀H₁₈O₁₀ = 538.46	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8706 mL	9.3528 mL	18.7056 mL	37.4111 mL	46.7639 mL
5 mM	0.3741 mL	1.8706 mL	3.7411 mL	7.4822 mL	9.3528 mL
10 mM	0.1871 mL	0.9353 mL	1.8706 mL	3.7411 mL	4.6764 mL
50 mM	0.0374 mL	0.1871 mL	0.3741 mL	0.7482 mL	0.9353 mL
100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.3741 mL	0.4676 mL