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  • 它莫西芬

    Tamoxifen

    它莫西芬
    产品编号 CFN93321
    CAS编号 10540-29-1
    分子式 = 分子量 C26H29NO = 371.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Xanthones
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    它莫西芬 CFN93321 10540-29-1 1mg QQ客服:1457312923
    它莫西芬 CFN93321 10540-29-1 5mg QQ客服:1457312923
    它莫西芬 CFN93321 10540-29-1 10mg QQ客服:1457312923
    它莫西芬 CFN93321 10540-29-1 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • Nanjing University of Chinese Medicine (China)
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  • University of Otago (New Zealand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Environ Toxicol.2023, 38(7):1641-1650.
  • Int J Mol Sci.2023, 24(3):2102.
  • Molecules.2021, 26(4):816.
  • Nutrients.2023, 15(4):950.
  • National Academy Science Letters2023, s40009.
  • J Asian Nat Prod Res.2019, 5:1-17
  • Horticulturae2020, 6(4),76.
  • Front Cell Dev Biol.2021, 9:764263.
  • J Microbiol Biotechnol.2023, 33(10):1317-1328.
  • Phytomedicine Plus2022, 2(1):100207.
  • Food Chem.2016, 191:81-90
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Sci Rep. 2017, 12953(7)
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Nat Prod Sci.2014, 20(3):182-190
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Antioxidants (Basel).2020, 9(6):544.
  • Pharmacognosy Magazine2024, 20(2):632-645.
  • Green Chem.2023, 25:5222-5232
  • Food Chem.2020, 332:127412
  • ...
  • 生物活性
    Description: Tamoxifen is currently the first-line therapy for treatment of hormone-dependent breast cancer, it acts as an estrogen agonist by preventing the skeletal alterations that result from ovarian hormone deficiency.
    Targets: Estrogen receptor | Progestogen receptor
    In vivo:
    J Bone Miner Res. 1987 Oct;2(5):449-56.
    Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats.[Pubmed: 3455628 ]
    To determine whether the nonsteroidal antiestrogen tamoxifen behaves as either an agonist or antagonist of estrogen on bone, the effects of ovariectomy, 17 beta-estradiol, and tamoxifen were compared on radial growth at the tibial diaphysis in young adult female rats.
    METHODS AND RESULTS:
    Ovariectomy and 17 beta-estradiol did not alter serum calcium, phosphate, or 25-hydroxyvitamin D. Ovariectomy increased serum 1,25-dihydroxyvitamin D in one experiment but not in the other. Tamoxifen increased the serum calcium and phosphate by itself and did not change serum 1,25-dihydroxyvitamin D in ovariectomized rats. Ovariectomy produced significant increases in medullary area, periosteal bone formation rate, and periosteal bone apposition rate compared to values in sham-operated animals and did not change endosteal bone formation rate. The increase in medullary area resulted from an increase in osteoclast number and resorbing surface length. Although endosteal forming surface length decreased, this was compensated for by an increase in the apposition rate. 17 beta-estradiol and tamoxifen each prevented the increases in bone formation rate and medullary area in ovariectomized rats. Tamoxifen reduced the length of the resorbing surface and osteoclast number to values observed in sham-operated animals.
    CONCLUSIONS:
    The findings demonstrate that in the rat, tamoxifen acts as an estrogen agonist by preventing the skeletal alterations that result from ovarian hormone deficiency.
    Cancer Res. 1999 Nov 1;59(21):5421-4.
    Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients.[Pubmed: 10554009]
    Tamoxifen is currently the first-line therapy for treatment of hormone-dependent breast cancer. However, despite initial benefits, most patients eventually relapse.
    METHODS AND RESULTS:
    Two groups of patients were identified: (a) a tamoxifen-sensitive group (n = 8); and (b) a tamoxifen-resistant group (n = 9). Using reverse transcription-PCR, the relative expression of mRNA for both estrogen receptor (ER) beta and transforming growth factor beta1 was determined in each patient group and quantified against a known reference standard. ER-beta mRNA was significantly up-regulated in the tamoxifen-resistant group as compared with the tamoxifen-sensitive group (P = 0.001 by Fisher's exact test), and, consistent with previous findings, transforming growth factor beta1 was also up-regulated in the tamoxifen-resistant cohort (P = 0.02).
    CONCLUSIONS:
    The importance of ER-beta in tamoxifen resistance was validated using tamoxifen-sensitive and -resistant cell lines, in which it was demonstrated that ER-beta mRNA was significantly up-regulated in the resistant cells. These results lend further support to a role for ER-beta as a poor prognostic factor in breast cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6917 mL 13.4586 mL 26.9172 mL 53.8344 mL 67.2929 mL
    5 mM 0.5383 mL 2.6917 mL 5.3834 mL 10.7669 mL 13.4586 mL
    10 mM 0.2692 mL 1.3459 mL 2.6917 mL 5.3834 mL 6.7293 mL
    50 mM 0.0538 mL 0.2692 mL 0.5383 mL 1.0767 mL 1.3459 mL
    100 mM 0.0269 mL 0.1346 mL 0.2692 mL 0.5383 mL 0.6729 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Gramodendrine; Gramodendrine CFN00443 83905-67-3 C21H27N3O = 337.40 5mg QQ客服:3257982914
    5-[(2R)-2-氨基丙基]-2,3-二氢-1-[3-(苄氧基)丙基]-1H-吲哚-7-腈; 5-[(2R)-2-Aminopropyl]-2,3-dihydro-1-[3-(phenylmethoxy)propyl]-1H-indole-7-carbonitrile CFN90001 459868-73-6 C22H27N3O = 349.47 5mg QQ客服:215959384
    5-[(2R)-2-氨基丙基]-2,3-二氢-1-[3-(苯甲酰氧基)丙基]-1H-吲哚-7-腈酒石酸盐; 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate CFN90023 239463-85-5 C26H31N3O8 = 513.55 5mg QQ客服:215959384
    3-Hydroxy-3-acetonyloxindole; 3-Hydroxy-3-acetonyloxindole CFN96171 33417-17-3 C11H11NO3 = 205.2 5mg QQ客服:215959384
    它莫西芬; Tamoxifen CFN93321 10540-29-1 C26H29NO = 371.51 5mg QQ客服:3257982914

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