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  • Strictosidinic acid

    • Strictosidinic acid

    Strictosidinic acid

    Strictosidinic acid
    		产品编号 CFN96657
    CAS编号 150148-81-5
    分子式 = 分子量 C26H32N2O9 = 516.54
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves of Psychotria myriantha.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Strictosidinic acid CFN96657 150148-81-5 1mg QQ客服：1413575084
    Strictosidinic acid CFN96657 150148-81-5 5mg QQ客服：1413575084
    Strictosidinic acid CFN96657 150148-81-5 10mg QQ客服：1413575084
    Strictosidinic acid CFN96657 150148-81-5 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Nanjing University of Chinese Medicine (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Commun.2023, 14(1):8142.
  • Antioxidants (Basel).2020, 9(2):E99
  • Food Chem.2022, 373(Pt B):131364.
  • J Med Food.2021, 24(3):209-217.
  • Nutrients.2022, 14(16):3393.
  • J Breast Cancer.2015, 18(2):112-118
  • South African Journal of Botany2024, 168:209-220.
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Vojnosanit Pregl2016, 75(00):391-391
  • Front Microbiol.2021, 12:736780.
  • LWT2020, 110397
  • Antioxidants (Basel).2023, 12(12):2131.
  • Mol Cells.2015, 38(9):765-72
  • Pharmaceutics.2021, 13(11):1839.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Aquaculture2019, 510:392-399
  • Pharmacognosy Journal.2022, 14,4,327-337.
  • Environ Toxicol.2022, 37(3):514-526.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Molecules.2021, 26(9):2802.
  • Sci Rep.2018, 8(1):12970
  • Int J Biol Macromol.2021, 199:189-200.
  • Dent Mater J. 2024, dmj.2023-294.
  • ...
    • 生物活性
    Description: Strictosidinic acid has an antiradical action against DPPH, it has a promising effect in the central nervous system.
    In vitro:
    Pharmaceutical Biology, 2008, 41(8):592-597.
    Anti-allergic and Antioxidative Activities of Some Compounds from Thai Medicinal Plants.[Reference: WebLink]

    METHODS AND RESULTS:
    In a DPPH radical scavenging assay, Strictosidinic acid and barakol were more potent than the positive control, BHT. The EC50 values of Strictosidinic acid and barakol were 27.68 and 39.62 μM, respectively. Other tested compounds, including lawsone methyl ether, bergenin, homorapanone and lucidin-ω-methyl ether, had weak antioxidative activities or no activity. In a nitrite assay, only lawsone methyl ether reduced nitrite production with an EC50 of 10.27 μM in RAW 264.7 cells.
    CONCLUSIONS:
    In conclusion, lawsone methyl ether suppresses degranulation in RBL-2H3 cells and reduces nitrite production in RAW 264.7 cells whereas Strictosidinic acid and barakol have an antiradical action against DPPH.
    In vivo:
    Phytomedicine. 2010 Mar;17(3-4):289-91.
    Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae).[Pubmed: 19576739]

    METHODS AND RESULTS:
    Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%).
    CONCLUSIONS:
    The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.936 mL 9.6798 mL 19.3596 mL 38.7192 mL 48.399 mL
    5 mM 0.3872 mL 1.936 mL 3.8719 mL 7.7438 mL 9.6798 mL
    10 mM 0.1936 mL 0.968 mL 1.936 mL 3.8719 mL 4.8399 mL
    50 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.968 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3872 mL 0.484 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢卡丹宾; 3alpha-dihydrocadambine CFN80224 54483-84-0 C27H34N2O10 = 546.22 5mg QQ客服：215959384
    瓦来西亚朝它胺; Vallesiachotamine CFN92640 5523-37-5 C21H22N2O3 = 350.4 5mg QQ客服：3257982914
    异瓦来西亚朝它胺; Isovallesiachotamine CFN92641 34384-71-9 C21H22N2O3 = 350.4 5mg QQ客服：215959384
    16-表-异西特斯日钦碱; (16R)-E-Isositsirikine CFN96096 6519-27-3 C21H26N2O3 = 354.5 5mg QQ客服：215959384
    缝籽嗪; Geissoschizine CFN95566 439-66-7 C21H24N2O3 = 352.4 5mg QQ客服：1413575084
    缝籽木蓁甲醚; Geissoschizine methyl ether CFN89459 60314-89-8 C22H26N2O3 = 366.45 10mg QQ客服：2159513211
    西特斯日钦碱; Sitsirikine CFN96218 1245-00-7 C21H26N2O3 = 354.5 5mg QQ客服：1457312923
    去氢毛钩藤碱; Hirsuteine CFN90615 35467-43-7 C22H26N2O3 = 366.45 5mg QQ客服：1457312923
    毛钩藤碱; Hirsutine CFN90617 7729-23-9 C22H28N2O3 = 368.47 5mg QQ客服：1413575084
    (16R)-二氢西特斯日钦碱; (16R)-Dihydrositsirikine CFN97115 6519-26-2 C21H28N2O3 = 356.5 5mg QQ客服：215959384

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