Strictosidinic acid

	产品编号	CFN96657
	CAS编号	150148-81-5
	分子式 = 分子量	C₂₆H₃₂N₂O₉ = 516.54
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The leaves of Psychotria myriantha.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Strictosidinic acid	CFN96657	150148-81-5	1mg	QQ客服：2056216494
Strictosidinic acid	CFN96657	150148-81-5	5mg	QQ客服：2056216494
Strictosidinic acid	CFN96657	150148-81-5	10mg	QQ客服：2056216494
Strictosidinic acid	CFN96657	150148-81-5	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universite de Lille1 (France)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

CSIRO - Agriculture Flagship (Australia)

National Cancer Center Research Institute (Japan)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Universiti Putra Malaysia(UPM) (Malaysia)

University of East Anglia (United Kingdom)

University of Maryland (USA)

Chinese University of Hong Kong (China)

National Hellenic Research Foundation (Greece)

University of Hertfordshire (United Kingdom)

Korea Institute of Oriental Medicine (Korea)

Univerzita Karlova v Praze (Czech Republic)

Florida International University (USA)

More...

Description:

Strictosidinic acid has an antiradical action against DPPH, it has a promising effect in the central nervous system.

In vitro:

Pharmaceutical Biology, 2008, 41(8):592-597.

Anti-allergic and Antioxidative Activities of Some Compounds from Thai Medicinal Plants.[Reference: WebLink]

METHODS AND RESULTS:
In a DPPH radical scavenging assay, Strictosidinic acid and barakol were more potent than the positive control, BHT. The EC50 values of Strictosidinic acid and barakol were 27.68 and 39.62 μM, respectively. Other tested compounds, including lawsone methyl ether, bergenin, homorapanone and lucidin-ω-methyl ether, had weak antioxidative activities or no activity. In a nitrite assay, only lawsone methyl ether reduced nitrite production with an EC50 of 10.27 μM in RAW 264.7 cells.
CONCLUSIONS:
In conclusion, lawsone methyl ether suppresses degranulation in RBL-2H3 cells and reduces nitrite production in RAW 264.7 cells whereas Strictosidinic acid and barakol have an antiradical action against DPPH.

In vivo:

Phytomedicine. 2010 Mar;17(3-4):289-91.

Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae).[Pubmed: 19576739]

METHODS AND RESULTS:
Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%).
CONCLUSIONS:
The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Strictosidinic acid; Strictosidinic acid	CFN96657	150148-81-5	C₂₆H₃₂N₂O₉ = 516.54	5mg	QQ客服：2159513211
3Beta-异二氢卡丹宾碱 4-氧化物; 3Beta-Isodihydrocadambine 4-oxide	CFN92745	1092371-18-0	C₂₇H₃₄N₂O₁₁ = 562.6	5mg	QQ客服：215959384
二氢卡丹宾; 3alpha-dihydrocadambine	CFN80224	54483-84-0	C₂₇H₃₄N₂O₁₀ = 546.22	5mg	QQ客服：3257982914
瓦来西亚朝它胺; Vallesiachotamine	CFN92640	5523-37-5	C₂₁H₂₂N₂O₃ = 350.4	5mg	QQ客服：215959384
异瓦来西亚朝它胺; Isovallesiachotamine	CFN92641	34384-71-9	C₂₁H₂₂N₂O₃ = 350.4	5mg	QQ客服：2159513211
16-表-异西特斯日钦碱; (16R)-E-Isositsirikine	CFN96096	6519-27-3	C₂₁H₂₆N₂O₃ = 354.5	5mg	QQ客服：215959384
缝籽嗪; Geissoschizine	CFN95566	439-66-7	C₂₁H₂₄N₂O₃ = 352.4	5mg	QQ客服：215959384
缝籽木蓁甲醚; Geissoschizine methyl ether	CFN89459	60314-89-8	C₂₂H₂₆N₂O₃ = 366.45	10mg	QQ客服：2056216494
西特斯日钦碱; Sitsirikine	CFN96218	1245-00-7	C₂₁H₂₆N₂O₃ = 354.5	5mg	QQ客服：2159513211
去氢毛钩藤碱; Hirsuteine	CFN90615	35467-43-7	C₂₂H₂₆N₂O₃ = 366.45	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.936 mL	9.6798 mL	19.3596 mL	38.7192 mL	48.399 mL
5 mM	0.3872 mL	1.936 mL	3.8719 mL	7.7438 mL	9.6798 mL
10 mM	0.1936 mL	0.968 mL	1.936 mL	3.8719 mL	4.8399 mL
50 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.7744 mL	0.968 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.3872 mL	0.484 mL